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View article: Prolonged survival in a patient with pbrm1 mutated metastatic cholangiocarcinoma receiving tazemetostat
Prolonged survival in a patient with pbrm1 mutated metastatic cholangiocarcinoma receiving tazemetostat Open
View article: The Role of the Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 in Breast Cancer Pathophysiology
The Role of the Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 in Breast Cancer Pathophysiology Open
The heparan sulfate proteoglycan syndecan-3 (SDC3) is a critical regulator of cell–matrix interactions. While other syndecan family members contribute to the progression of multiple cancers, SDC3’s functional contributions to tumor biology…
View article: Mortality, functional outcome, and bleeding risk after early versus delayed thrombectomy
Mortality, functional outcome, and bleeding risk after early versus delayed thrombectomy Open
Endovascular thrombectomy (EVT) is an established treatment for acute ischemic stroke, due to large vessel occlusion (LVO), but the optimal time window for intervention remains a subject of ongoing debate. We aimed to assess the impact of …
View article: Recent advances in treating age-related macular degeneration and diabetic retinopathy: Current therapies and emerging novel approaches
Recent advances in treating age-related macular degeneration and diabetic retinopathy: Current therapies and emerging novel approaches Open
The incidence of retinopathies is expected to increase globally as our population ages and diabetes becomes more prevalent. Neovascular age-related macular degeneration (nAMD) and proliferative diabetic retinopathy (PDR) are major causes o…
View article: Senescence-associated gene signatures predict survival in lung cancer: a multi-cohort analysis
Senescence-associated gene signatures predict survival in lung cancer: a multi-cohort analysis Open
Lung cancer is a leading cause of cancer-related mortality worldwide and is predominantly diagnosed in older adults, underscoring the need to explore aging-related biological mechanisms that influence disease progression and prognosis. Cel…
View article: Subtype-specific genetic drivers of immune evasion in breast cancer
Subtype-specific genetic drivers of immune evasion in breast cancer Open
We identified subtype-specific signatures that predict survival and immunotherapy response, providing clinically actionable biomarkers.
View article: Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling
Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling Open
View article: PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding
PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding Open
Peroxisome proliferator-activated receptor γ (PPARγ), which is expressed in a variety of malignancies, governs biological functions through transcriptional programs. Defining the molecular mechanisms governing the selection of canonical ve…
View article: Transforming Researcher Evaluation: A New Global Platform to Measure Impact Across Disciplines
Transforming Researcher Evaluation: A New Global Platform to Measure Impact Across Disciplines Open
Ranking researchers based solely on raw metrics such as citation counts or the H-index can introduce significant biases. These measures often disadvantage early-career scientists and those working in disciplines with distinct publication n…
View article: Identification of Deregulated Proteins in Mutated BRCA1/2 Breast and Ovarian Cancers for Vectorized Biologics
Identification of Deregulated Proteins in Mutated BRCA1/2 Breast and Ovarian Cancers for Vectorized Biologics Open
Background: Administration of PARP inhibitors against breast and ovarian cancers with BRCA1 and BRCA2 mutations has shown clinical benefits in patients. However, these agents are also toxic and have a narrow therapeutic index. Objectives: …
View article: PCSK9 expression and cancer survival: a prognostic biomarker at the intersection of oncology and geroscience
PCSK9 expression and cancer survival: a prognostic biomarker at the intersection of oncology and geroscience Open
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily recognized for its role in cholesterol metabolism; however, emerging evidence suggests it plays a broader role in the regulation of cellular aging mechanisms and the pathog…
View article: <scp>CTHRC1</scp> promotes bone metastasis in prostate cancer
<span>CTHRC1</span> promotes bone metastasis in prostate cancer Open
Prostate cancer causes a high frequency of bone metastases. The purpose of this study was to identify molecules that regulate prostate cancer bone metastasis as potential therapeutic and/or prognostic targets in prostate cancer, using inte…
View article: The Prognostic Value of the Hedgehog Signaling Pathway in Ovarian Cancer
The Prognostic Value of the Hedgehog Signaling Pathway in Ovarian Cancer Open
The hedgehog pathway is a major regulator of cell growth and differentiation during embryogenesis and early development. The literature suggests that variations in this pathway’s genes play a role in tumor progression and response to thera…
View article: NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions
NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions Open
Lung cancer is a leading cause of cancer-related mortality worldwide. As an age-related disease, its pathogenesis is shaped by several molecular hallmarks of aging, including impaired DNA repair and diminished stress resilience. The transc…
View article: The Role of the Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 In Breast Cancer Pathophysiology
The Role of the Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 In Breast Cancer Pathophysiology Open
The heparan sulfate proteoglycan syndecan-3 (SDC3) has emerged as a critical regulator of cell-matrix interactions. While other syndecan family members con-tribute to the progression of multiple cancers, SDC3's functional contributions to …
View article: Multiplicity corrections in life sciences: challenges and consequences
Multiplicity corrections in life sciences: challenges and consequences Open
View article: Quantifying the impact of treatment delays on breast cancer survival outcomes: a comprehensive meta-analysis
Quantifying the impact of treatment delays on breast cancer survival outcomes: a comprehensive meta-analysis Open
Treatment delay in breast cancer care represents a significant concern in oncology, potentially impacting patient survival outcomes. While various factors can contribute to delayed treatment initiation, the quantitative relationship betwee…
View article: Truncated DAPK Variants Restore Tumor Suppressor Activity and Synergize with Standard Therapies in High-Grade Serous Ovarian Cancer
Truncated DAPK Variants Restore Tumor Suppressor Activity and Synergize with Standard Therapies in High-Grade Serous Ovarian Cancer Open
Background/Objectives: Death-associated protein kinase 1 (DAPK1) is a serine/threonine kinase that plays a crucial role in cancer by regulating apoptosis through interactions with TP53. Aberrant expression of DAPK1 was shown in certain typ…
View article: Adipocyte/Tumor cell crosstalk via IGF-1/TXNIP axis promotes malignancy and endocrine resistance in breast cancer
Adipocyte/Tumor cell crosstalk via IGF-1/TXNIP axis promotes malignancy and endocrine resistance in breast cancer Open
Background Despite significant improvements in the outcome of Estrogen Receptor (ER) α-positive breast cancer (BC) following the use of endocrine therapies, resistance remains a major challenge. Clinical studies proved that obesity, in add…
View article: Exploring immune activation patterns in HER2-low and HER2-ultralow breast cancer subtypes
Exploring immune activation patterns in HER2-low and HER2-ultralow breast cancer subtypes Open
Background A deeper understanding of the molecular and clinical characteristics of HER2-low and ultralow breast cancer (BC) subtypes is essential for advancing therapeutic strategies. Methods Three independent GEO datasets with microarray …
View article: In silico evaluation of the immunogenic profile of lung cancers with SMARCA4 genetic alterations
In silico evaluation of the immunogenic profile of lung cancers with SMARCA4 genetic alterations Open
Genomic alterations in tumor cells can influence immune response, as has been demonstrated in several tumor types. For instance, mutations in certain genes like EGFR or B-RAF are associated with a particular immune phenotype. Non-small cel…
View article: Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high‐grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models
Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high‐grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models Open
View article: Quantum Size Effects on Andreev Transport in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mi>Nb</mml:mi><mml:mo>/</mml:mo><mml:mi>Au</mml:mi><mml:mo>/</mml:mo><mml:mi>Nb</mml:mi></mml:mrow></mml:math> Josephson Junctions: A Combined <i>Ab Initio</i> and Experimental Study
Quantum Size Effects on Andreev Transport in Josephson Junctions: A Combined <i>Ab Initio</i> and Experimental Study Open
We have measured the critical current density, superconducting coherence length, and superconducting transition temperature of single-domain, epitaxially grown Nb(110)/Au(111)/Nb(110) trilayers, all of which show a nonmonotonic dependence …
View article: No detectable impact of short-term treatment delays on lung cancer survival
No detectable impact of short-term treatment delays on lung cancer survival Open
Timely initiation of treatment is a core principle of oncologic care, especially for aggressive cancers such as lung cancer. However, the real-world impact of short-term delays in treatment initiation on survival outcomes in lung cancer re…
View article: Melanoma Proteomics Unveiled: Harmonizing Diverse Data Sets for Biomarker Discovery and Clinical Insights via MEL-PLOT
Melanoma Proteomics Unveiled: Harmonizing Diverse Data Sets for Biomarker Discovery and Clinical Insights via MEL-PLOT Open
Using several melanoma proteomics data sets we created a single analysis platform that enables the discovery, knowledge build, and validation of diagnostic, predictive, and prognostic biomarkers at the protein level. Quantitative mass-spec…
View article: Depression increases cancer mortality by 23–83%: a meta-analysis of 65 studies across five major cancer types
Depression increases cancer mortality by 23–83%: a meta-analysis of 65 studies across five major cancer types Open
Depression is a prevalent but often underrecognized comorbidity among cancer patients. Emerging evidence suggests that psychological distress may adversely impact cancer outcomes, but the magnitude of its effect on survival remains unclear…
View article: 72P Predictive value of spatially-derived archetypes and tertiary lymphoid structure signature in the NeoTRIP trial
72P Predictive value of spatially-derived archetypes and tertiary lymphoid structure signature in the NeoTRIP trial Open
View article: Abstract 2238 CNTNAP2 hypermethylation in colorectal adenocarcinoma
Abstract 2238 CNTNAP2 hypermethylation in colorectal adenocarcinoma Open
View article: Abstract 2190 An Integrated Transcriptomic Database with Stage-Stratified Analysis of Breast Cancer: A Web-Based Tool for Biomarker Discovery and Therapeutic Target Identification
Abstract 2190 An Integrated Transcriptomic Database with Stage-Stratified Analysis of Breast Cancer: A Web-Based Tool for Biomarker Discovery and Therapeutic Target Identification Open
View article: Abstract 2267 Cross-cellular gene expression analysis in colorectal cancer: a unified platform for tumor microenvironment investigation
Abstract 2267 Cross-cellular gene expression analysis in colorectal cancer: a unified platform for tumor microenvironment investigation Open