Balint Doleschall
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View article: ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum
ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum Open
Mutations in ARID1B, a member of the mSWI/SNF complex, cause severe neurodevelopmental phenotypes with elusive mechanisms in humans. The most common structural abnormality in the brain of ARID1B patients is agenesis of the corpus callosum …
View article: In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids
In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids Open
Ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are involved in movement control and reward-related cognition. In Parkinson’s disease, nigrostriatal midbrain dopaminergic neurons degenerate and cause…
View article: ARID1B controls transcriptional programs of axon projection in the human corpus callosum
ARID1B controls transcriptional programs of axon projection in the human corpus callosum Open
Mutations in ARID1B , a member of the mSWI/SNF complex, cause severe neurodevelopmental phenotypes with elusive mechanisms in humans. The most common structural abnormality in the brain of ARID1B patients is agenesis of the corpus callosum…
View article: Identification of a population of peripheral sensory neurons that regulates blood pressure
Identification of a population of peripheral sensory neurons that regulates blood pressure Open
View article: Intraarticular Adeno‐Associated Virus Serotype AAV‐PHP.S–Mediated Chemogenetic Targeting of Knee‐Innervating Dorsal Root Ganglion Neurons Alleviates Inflammatory Pain in Mice
Intraarticular Adeno‐Associated Virus Serotype AAV‐PHP.S–Mediated Chemogenetic Targeting of Knee‐Innervating Dorsal Root Ganglion Neurons Alleviates Inflammatory Pain in Mice Open
Objective Joint pain is the major clinical symptom of arthritis that affects millions of people. Controlling the excitability of knee‐innervating dorsal root ganglion ( DRG ) neurons (knee neurons) could potentially provide pain relief. We…
View article: Data to support: Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice
Data to support: Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice Open
The files contain the raw data to support the publication and are organised into separate files, each one corresponding to a different figure in the paper.\n\nAlongside the raw data, the statistical analyses used in the published paper are…
View article: Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice
Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice Open
Objective Joint pain is the major clinical symptom of arthritis that affects millions of people. Controlling the excitability of knee-innervating dorsal root ganglion (DRG) neurons (knee neurons) could potentially provide pain relief. Ther…
View article: Identification of a novel population of peripheral sensory neuron that regulates blood pressure
Identification of a novel population of peripheral sensory neuron that regulates blood pressure Open
Summary The vasculature is innervated by a network of peripheral afferents that sense and regulate blood flow. Here, we describe a system of non-peptidergic sensory neurons with cell bodies in the spinal ganglia that regulate vascular tone…
View article: A ligand-based system for receptor-specific delivery of proteins
A ligand-based system for receptor-specific delivery of proteins Open
Gene delivery using vector or viral-based methods is often limited by technical and safety barriers. A promising alternative that circumvents these shortcomings is the direct delivery of proteins into cells. Here we introduce a non-viral, …
View article: Nerve growth factor–mediated photoablation of nociceptors reduces pain behavior in mice
Nerve growth factor–mediated photoablation of nociceptors reduces pain behavior in mice Open
Nerve growth factor (NGF) and its receptors TrkA and p75 play a key role in the development and function of peripheral nociceptive neurons. Here, we describe novel technology to selectively photoablate TrkA-positive nociceptors through del…