Ballachanda N. Devaiah
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View article: BRD4 regulates Aurora B kinase activity
BRD4 regulates Aurora B kinase activity Open
BRD4, a pleiotropic regulator of chromatin structure and transcription, plays critical roles in cancer and immune responses. Unlike other transcriptional regulators, BRD4 largely remains bound to chromosomes during early mitosis. Here we r…
View article: The ESCRT protein CHMP5 promotes T cell leukemia by controlling BRD4-p300-dependent transcription
The ESCRT protein CHMP5 promotes T cell leukemia by controlling BRD4-p300-dependent transcription Open
Summary Oncogene activity rewires cellular transcription, creating new transcription networks to which cancer cells become addicted, by mechanisms that are still poorly understood. Using human and mouse models of T cell acute lymphoblastic…
View article: Editorial: BET proteins in chromatin architecture, transcription and disease
Editorial: BET proteins in chromatin architecture, transcription and disease Open
EDITORIAL article Front. Mol. Biosci., 22 July 2022Sec. Cellular Biochemistry Volume 9 - 2022 | https://doi.org/10.3389/fmolb.2022.977812
View article: <scp>BRD4</scp>and<scp>MYC</scp>: power couple in transcription and disease
<span>BRD4</span>and<span>MYC</span>: power couple in transcription and disease Open
The MYC proto‐oncogene and BRD4, a BET family protein, are two cardinal proteins that have a broad influence in cell biology and disease. Both proteins are expressed ubiquitously in mammalian cells and play central roles in controlling gro…
View article: The nuclear transcription factor, TAF7, is a cytoplasmic regulator of protein synthesis
The nuclear transcription factor, TAF7, is a cytoplasmic regulator of protein synthesis Open
Transcription factor TAF7 links transcription and translation by delivering its transcripts to polysomes for translation.
View article: The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains
The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains Open
Bromodomain protein 4 (BRD4) is a transcriptional and epigenetic regulator that is a therapeutic target in many cancers and inflammatory diseases. BRD4 plays important roles in transcription as an active kinase, which phosphorylates the ca…
View article: MYC protein stability is negatively regulated by BRD4
MYC protein stability is negatively regulated by BRD4 Open
The protooncogene MYC regulates a variety of cellular processes, including proliferation and metabolism. Maintaining MYC at homeostatic levels is critical to normal cell function; overexpression drives many cancers. MYC stability is regula…
View article: Bromodomain 4: a cellular Swiss army knife
Bromodomain 4: a cellular Swiss army knife Open
Bromodomain protein 4 (BRD4) is a transcriptional and epigenetic regulator that plays a pivotal role in cancer and inflammatory diseases. BRD4 binds and stays associated with chromatin during mitosis, bookmarking early G1 genes and reactiv…