Ballamoole Krishna Kumar
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View article: Molecular profiling of antibiotic resistance genes in acute and chronic irreversible pulpitis: A cross-sectional study
Molecular profiling of antibiotic resistance genes in acute and chronic irreversible pulpitis: A cross-sectional study Open
Context: Antimicrobial resistance represents a global health crisis, with the oral microbiome serving as a significant reservoir for resistance genes. Despite guidelines discouraging antibiotic use for irreversible pulpitis, empirical pres…
View article: Virulence Potential of Nonclinical <i>Vibrio parahaemolyticus</i> Isolates From Vietnam: Evidence for Functional T3SS2‐Mediated Enterotoxicity
Virulence Potential of Nonclinical <i>Vibrio parahaemolyticus</i> Isolates From Vietnam: Evidence for Functional T3SS2‐Mediated Enterotoxicity Open
Vibrio parahaemolyticus is a leading cause of seafood‐borne gastroenteritis worldwide, and its pathogenic strains typically harbor thermostable direct hemolysin (TDH) and type III secretion system 2 (T3SS2). Although these virulence factor…
View article: Novel lytic bacteriophage AhFM11 as an effective therapy against hypervirulent Aeromonas hydrophila
Novel lytic bacteriophage AhFM11 as an effective therapy against hypervirulent Aeromonas hydrophila Open
Several farmed fish species, including carps, tilapia, salmon, and catfish, have experienced significant economic losses in aquaculture due to motile Aeromonas septicemia caused by Aeromonas hydrophila . In the present study, a novel lytic…
View article: Identification of Dominant Leptospira Serogroups among Leptospirosis Cases and Their Clinical Outcomes: A Prospective Hospital-Based Study in Mangaluru, India
Identification of Dominant Leptospira Serogroups among Leptospirosis Cases and Their Clinical Outcomes: A Prospective Hospital-Based Study in Mangaluru, India Open
Leptospirosis is a reemerging zoonotic disease of worldwide significance, endemic to the southern region of India, with clinical manifestations similar to other febrile illnesses; hence, it is often misdiagnosed and underreported. Inadequa…
View article: Role of periodontal pathogens in atherosclerotic plaque development and progression: An overview
Role of periodontal pathogens in atherosclerotic plaque development and progression: An overview Open
Atherosclerosis is a progressive disease marked by the accumulation of lipids and fibrous components in the large arteries. It is one of the primary causes of heart disease and stroke. Periodontal diseases encompass conditions like gingivi…
View article: Role of oral microbiota in irreversible pulpitis – Current strategies and future perspectives
Role of oral microbiota in irreversible pulpitis – Current strategies and future perspectives Open
Irreversible pulpitis is an inflammation of the tooth pulp caused by an opportunity-driven invasion of the pulp space by oral microbiota typically prevalent in the oral cavity. Microbial organisms are extensively recognised to be the funda…
View article: Genome analysis of clinical genotype <i>Vibrio vulnificus</i> isolated from seafood in Mangaluru Coast, India provides insights into its pathogenicity
Genome analysis of clinical genotype <i>Vibrio vulnificus</i> isolated from seafood in Mangaluru Coast, India provides insights into its pathogenicity Open
Vibrio vulnificus an opportunistic human pathogen native to marine/estuarine environment, is one of the leading causes of death due to seafood consumption and exposure of wounds to seawater worldwide. The present study involves the …
View article: Metagenomic Analysis to Uncover the Subgingival and Atherosclerotic Plaque Microbiota in Patients with Coronary Artery Disease
Metagenomic Analysis to Uncover the Subgingival and Atherosclerotic Plaque Microbiota in Patients with Coronary Artery Disease Open
View article: In-silico Analysis of Human Papillomavirus – 45 E6, E7 & L1 Proteins as Potential Immunogens
In-silico Analysis of Human Papillomavirus – 45 E6, E7 & L1 Proteins as Potential Immunogens Open
Globally, cervical cancer is the fourth most common cancer among women. After being cloned from a recurring cervical lesion in 1987, Human papillomavirus (HPV) type-45 was identified as a high-risk HPV type. It is the third most common can…
View article: Genome analysis of clinical genotype <i>Vibrio vulnificus</i> isolated from seafood in Mangaluru Coast, India provides insights into its pathogenicity
Genome analysis of clinical genotype <i>Vibrio vulnificus</i> isolated from seafood in Mangaluru Coast, India provides insights into its pathogenicity Open
Vibrio vulnificus an opportunistic human pathogen native to marine/estuarine environment, is one of the leading causes of death due to seafood consumption and exposure of wounds to seawater worldwide. The present study involves the …
View article: Genome analysis of clinical isolate of Campylobacter fetus subspecies fetus MMM01 from India reveals genetic determinants of pathogenesis and adaptation
Genome analysis of clinical isolate of Campylobacter fetus subspecies fetus MMM01 from India reveals genetic determinants of pathogenesis and adaptation Open
In this study we report the whole genome sequencing (WGS) based analysis of blood-borne Campylobacter fetus subsp. fetus MMM01 isolated from a diabetic patient to obtain deeper insights in to the virulence and host adaptability. The sequen…
View article: Assessment of Periodontal Disease Severity in Patients with Cardiovascular Disease
Assessment of Periodontal Disease Severity in Patients with Cardiovascular Disease Open
Background: Periodontitis is a biofilm-induced chronic inflammatory disease that affects the tooth-supporting structures. Transient bacteremia during periodontal infection may lead to direct bacterial invasion of endothelial cells. Aim: To…
View article: Unravelling the Distinctive Virulence Traits and Clonal Relationship among the Pseudomonas aeruginosa Isolates from Diabetic Patients
Unravelling the Distinctive Virulence Traits and Clonal Relationship among the Pseudomonas aeruginosa Isolates from Diabetic Patients Open
Infections with P. aeruginosa are three times more common in people with diabetes than in non-diabetic individuals. Investigations disclosing the distinguishing traits of P. aeruginosa strains to cause respiratory and wound infection in di…
View article: Pathogenic potential of non-clinical Vibrio parahaemolyticus strains isolated from the aquatic environments in Southern India
Pathogenic potential of non-clinical Vibrio parahaemolyticus strains isolated from the aquatic environments in Southern India Open
Purpose: Vibrio parahaemolyticus is a Gram-negative, halophilic bacterium responsible for diarrheal illness in humans upon consumption of contaminated seafood. Recent studies have shown virulence attributes which are usually associated wit…
View article: Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics
Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics Open
Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As a result, infectious diseases have become more challenging or even impossible to treat, leading …
View article: Quorum Sensing Regulation of Virulence Gene Expression in Vibrio harveyi during its Interaction with Marine Diatom Skeletonema marinoi
Quorum Sensing Regulation of Virulence Gene Expression in Vibrio harveyi during its Interaction with Marine Diatom Skeletonema marinoi Open
Communication between species from different kingdoms may be as important as intra-kingdom communication. It has recently been confirmed that co-existing bacteria and phytoplankton in aquatic ecosystems do cross-talk. This study examined t…
View article: The Dominance of Severe Acute Respiratory Syndrome Coronavirus 2 B.1.617 and Its Sublineages and Associations with Mortality during the COVID-19 Pandemic in India between 2020 and 2021
The Dominance of Severe Acute Respiratory Syndrome Coronavirus 2 B.1.617 and Its Sublineages and Associations with Mortality during the COVID-19 Pandemic in India between 2020 and 2021 Open
As the COVD-19 pandemic spreads, several new severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) variants with various mutations across the genome have arisen, and they appear to be the greater risk to global public health. In thi…
View article: Whole genome analysis unveils genetic diversity and potential virulence determinants in <i>Vibrio parahaemolyticus</i> associated with disease outbreak among cultured <i>Litopenaeus vannamei</i> (Pacific white shrimp) in India
Whole genome analysis unveils genetic diversity and potential virulence determinants in <i>Vibrio parahaemolyticus</i> associated with disease outbreak among cultured <i>Litopenaeus vannamei</i> (Pacific white shrimp) in India Open
Vibrio parahaemolyticus has caused widespread mortality in Indian shrimp aquaculture in recent years. However, there are insufficient genome data for the isolates from Indian shrimp vibriosis to analyze genetic diversity and track t…
View article: Advances in Environmental Detection and Clinical Diagnostic Tests for Legionella Species
Advances in Environmental Detection and Clinical Diagnostic Tests for Legionella Species Open
Legionella is a fastidious organism that is difficult to culture in the lab but is widely distributed in environmental, domestic, and hospital settings. The clinical manifestations due to Legionella infections range from mild fever to fata…
View article: Genetic Diversity of the Legionella pneumophila dotA Gene Detected on Surfaces of Respiratory Therapy Equipment
Genetic Diversity of the Legionella pneumophila dotA Gene Detected on Surfaces of Respiratory Therapy Equipment Open
Legionellosis is a neglected disease due to the absence of well-defined clinical symptoms and difficulties in isolating the causal organism. Legionella spp. is known to colonize the lumen of respiratory therapy equipment(RTE) and evade con…
View article: Preliminary Evidence from a Cross-sectional Study on Epidemiology and Early Transmission Dynamics of COVID-19 in Karnataka State of India
Preliminary Evidence from a Cross-sectional Study on Epidemiology and Early Transmission Dynamics of COVID-19 in Karnataka State of India Open
Introduction Coronavirus disease 2019 (COVID-19) is an emerging infection and quickly disseminated around the world. This article studies the epidemiology and early transmission dynamics of COVID-19 in Karnataka, which would be useful for …
View article: Phenotypic Characterization of Auxotrophic Mutant of Nontyphoidal Salmonella and Determination of Its Cytotoxicity, Tumor Inhibiting Cytokine Gene Expression in Cell Line Models
Phenotypic Characterization of Auxotrophic Mutant of Nontyphoidal Salmonella and Determination of Its Cytotoxicity, Tumor Inhibiting Cytokine Gene Expression in Cell Line Models Open
An auxotrophic mutant of non-typhoidal Salmonella (NTS) strain was phenotypically characterized in this study. The characterization was based on phenotype, morphology, motility, biofilm forming ability, growth kinetics, etc. The phenotypic…
View article: Molecular analysis shows the presence of periodontal bacterial DNA in atherosclerotic plaques from patients with coronary artery disease
Molecular analysis shows the presence of periodontal bacterial DNA in atherosclerotic plaques from patients with coronary artery disease Open
View article: Iron Content as an Indicator for Legionella Species in Artificial Water Systems
Iron Content as an Indicator for Legionella Species in Artificial Water Systems Open
Following is the data which shows the presence of Legionella spp. in both natural and artificial sources of water, especially in municipal water supply systems. In our study, we show that iron concentration at the sites of bacterial…
View article: Detection technologies and recent developments in the diagnosis of COVID-19 infection
Detection technologies and recent developments in the diagnosis of COVID-19 infection Open
View article: Deletion in the C-terminal region of the envelope glycoprotein in some of the Indian SARS-CoV-2 genome
Deletion in the C-terminal region of the envelope glycoprotein in some of the Indian SARS-CoV-2 genome Open
View article: Exploring the Pathogenic Potential of Vibrio vulnificus Isolated from Seafood Harvested along the Mangaluru Coast, India
Exploring the Pathogenic Potential of Vibrio vulnificus Isolated from Seafood Harvested along the Mangaluru Coast, India Open
It has been observed that not all strains of Vibrio vulnificus are virulent. Determining the virulence of strains that are frequently present in seafood is of significance for ensuring seafood safety. This study is an attempt to predict th…
View article: Draft genome sequences of <i>Salmonella</i> Oslo isolated from seafood and its laboratory generated auxotrophic mutant
Draft genome sequences of <i>Salmonella</i> Oslo isolated from seafood and its laboratory generated auxotrophic mutant Open
In recent years, the concept of bacteria-mediated cancer therapy has gained significant attention as an alternative to conventional therapy. The focus has been on non-typhoidal Salmonella (NTS), particularly S. Typhimurium, f…
View article: PCR-based evidence showing the presence of Vibrio vulnificus in wound infection cases in Mangaluru, India
PCR-based evidence showing the presence of Vibrio vulnificus in wound infection cases in Mangaluru, India Open
View article: Antibiotic Resistance and Molecular Characterization of Seafood Isolates of Nontyphoidal Salmonella by PFGE
Antibiotic Resistance and Molecular Characterization of Seafood Isolates of Nontyphoidal Salmonella by PFGE Open
Emergence of multidrug resistant nontyphoidal Salmonella is a major health concern worldwide due to the predominant occurrence of Salmonella enterica sub-species enterica serovar Typhimurium phage type 104 (DT104) conferring resistance to …