Bandar A. Suliman
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View article: Genomic surveillance of Methicillin Resistant <i>Staphylococcus aureus</i> in Saudi Arabia
Genomic surveillance of Methicillin Resistant <i>Staphylococcus aureus</i> in Saudi Arabia Open
Methicillin-resistant Staphylococcus aureus (MRSA) surveillance in regions with mass gatherings presents unique challenges for public health systems. Saudi Arabia, hosting millions of pilgrims annually, provides a distinctive setting for s…
View article: Silent reactivation of Varicella Zoster virus in hemodialysis patients.
Silent reactivation of Varicella Zoster virus in hemodialysis patients. Open
In conclusion, significantly higher VZV seroprevalence and antibody levels in HDP indicate greater viral exposure than HC. Screening of hemodialysis (HD) to VZV serologically or at the molecular level is most important to avoid the consequ…
View article: Investigating the potential role of T helper 17 cells among women experiencing overweight and obesity and their possible therapeutic targeting of the RORγt molecule
Investigating the potential role of T helper 17 cells among women experiencing overweight and obesity and their possible therapeutic targeting of the RORγt molecule Open
View article: Potential clinical implications of molecular mimicry‐induced autoimmunity
Potential clinical implications of molecular mimicry‐induced autoimmunity Open
Background Molecular mimicry is hypothesized to be a mechanism by which autoimmune diseases are triggered. It refers to sequence or structural homology between foreign antigens and self‐antigens, which can activate cross‐reactive lymphocyt…
View article: Robust memory humoral immune response to SARS-CoV-2 in the tonsils of adults and children
Robust memory humoral immune response to SARS-CoV-2 in the tonsils of adults and children Open
Background Adaptive humoral immunity against SARS-CoV-2 has mainly been evaluated in peripheral blood. Human secondary lymphoid tissues (such as tonsils) contain large numbers of plasma cells that secrete immunoglobulins at mucosal sites. …
View article: Polymorphisms in the Drug Transporter Gene ABCB1 Are Associated with Drug Response in Saudi Epileptic Pediatric Patients
Polymorphisms in the Drug Transporter Gene ABCB1 Are Associated with Drug Response in Saudi Epileptic Pediatric Patients Open
Epilepsy is one of the most common chronic neurodisorders in the pediatric age group. Despite the availability of over 20 anti-seizure medications (ASMs) on the market, drug-resistant epilepsy still affects one-third of individuals. Conseq…
View article: Performance of an Antigen Rapid Test Compared to RT-PCR for the Detection of SARS-CoV-2
Performance of an Antigen Rapid Test Compared to RT-PCR for the Detection of SARS-CoV-2 Open
Background: Rapid and accurate diagnosis of COVID-19 is critical for the management of patients and to limit the spread of the infection. real-time reverse transcription polymerase chain reaction (RT- PCR) is the gold standard for the diag…
View article: The impact of consanguinity on women’s attitudes toward molecular testing of breast cancer in Saudi Arabia
The impact of consanguinity on women’s attitudes toward molecular testing of breast cancer in Saudi Arabia Open
Background: Breast cancer is the most common cancer in adult women in Saudi Arabia; however, awareness about molecular testing for breast cancer is insufficient. The authors aimed to assess knowledge and attitudes to determine sociodemogra…
View article: Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19
Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19 Open
A recent report found that rare predicted loss-of-function (pLOF) variants across 13 candidate genes in TLR3- and IRF7-dependent type I IFN pathways explain up to 3.5% of severe COVID-19 cases. We performed whole-exome or whole-genome sequ…
View article: Dynamics of COVID-19 Lockdown on Blood Indices and Its Impact on Individuals’ Immunological Health Status: A Cohort Study in Madinah, Saudi Arabia
Dynamics of COVID-19 Lockdown on Blood Indices and Its Impact on Individuals’ Immunological Health Status: A Cohort Study in Madinah, Saudi Arabia Open
Our findings suggested that the overall health status of individuals improved during the lockdown period in the short term, but health status might be adversely affected under these conditions of a longer period. Both RDW and PDW could be …
View article: The detection of SARS‐CoV‐2 in outpatient clinics and public facilities during the COVID‐19 pandemic
The detection of SARS‐CoV‐2 in outpatient clinics and public facilities during the COVID‐19 pandemic Open
The transmission of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can occur through an airborne route, in addition to contaminated surfaces and objects. In hospitals, it has been confirmed by several studies that SARS‐Co…
View article: TLR8 is highly conserved among the Saudi population and its mutations have no effect on the severity of COVID-19 symptoms.
TLR8 is highly conserved among the Saudi population and its mutations have no effect on the severity of COVID-19 symptoms. Open
Coronavirus 2019 (COVID-19) is an infection caused by the newly discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The innate system is the first line of defense against pathogens and diverse infectious agents. It has…
View article: Interleukin 6 is a two-edged sword: a centerpiece in the immune response against the SARS-CoV-2
Interleukin 6 is a two-edged sword: a centerpiece in the immune response against the SARS-CoV-2 Open
View article: Failure to replicate the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19
Failure to replicate the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19 Open
A recent report found that rare predicted loss-of-function (pLOF) variants across 13 candidate genes in TLR3- and IRF7-dependent type I IFN pathways explain up to 3.5% of severe COVID-19 cases. We performed whole-exome or whole-genome sequ…
View article: Modeling Three-Dimensional Geometric Shapes from Nucleic Acid Sequences Using a Computerized Numerical Control
Modeling Three-Dimensional Geometric Shapes from Nucleic Acid Sequences Using a Computerized Numerical Control Open
The nucleic acid sequence is an astonishing and a complicated coding system that is capable of producing a complete human body with of its molecules, cells, tissue and organs. Nucleic acid has been used in many fields of sciences for the p…
View article: A two-dimensional triangular medical coding system for storing and reporting medical information
A two-dimensional triangular medical coding system for storing and reporting medical information Open
Medical coding is an integral part of modern communication standards that help transform many types of clinical information such as patient information. The need to implement a standardized and a universal medical coding system is essentia…
View article: Comparison of five viral nucleic acid extraction kits for the efficient extraction of viral DNA and RNA from cell-free samples
Comparison of five viral nucleic acid extraction kits for the efficient extraction of viral DNA and RNA from cell-free samples Open
Extraction of viral nucleic acids from serum samples is widely used in diagnostic pathology tests.However, the heterogeneous nature of non-serum samples may contribute to variations in the yields of viral nucleic acids with different extra…
View article: Promyelocytic leukemia zinc finger triggers ATP‑binding cassette subfamily E member 1‑mediated growth inhibition in breast cancer cells
Promyelocytic leukemia zinc finger triggers ATP‑binding cassette subfamily E member 1‑mediated growth inhibition in breast cancer cells Open
The promyelocytic leukemia zinc finger (PLZF) protein is a transcription factor that is involved in a number of biological processes, including those regulating cellular growth; however, little is known regarding how it achieves its inhibi…
View article: MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile
MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Open
View article: The role of PLZF in the TLR-mediated inflammatory response and the oncogenic characteristics of renal cell carcinoma
The role of PLZF in the TLR-mediated inflammatory response and the oncogenic characteristics of renal cell carcinoma Open
The Promyelocytic Leukemia Zinc Finger protein (PLZF) is a transcription factor that belongs to the POK (POZ and Krüppel) family of transcriptional repressors. It functions by forming multi-protein nuclear co-repressor complexes that silen…
View article: A Comprehensive In Silico Analysis on the Structural and Functional Impact of SNPs in the Congenital Heart Defects Associated with NKX2-5 Gene—A Molecular Dynamic Simulation Approach
A Comprehensive In Silico Analysis on the Structural and Functional Impact of SNPs in the Congenital Heart Defects Associated with NKX2-5 Gene—A Molecular Dynamic Simulation Approach Open
Congenital heart defects (CHD) presented as structural defects in the heart and blood vessels during birth contribute an important cause of childhood morbidity and mortality worldwide. Many Single nucletotide polymorphisms (SNPs) in differ…
View article: The generation of a ZBTB16-inducible expression system in the ACHN adenocarcinoma cell line
The generation of a ZBTB16-inducible expression system in the ACHN adenocarcinoma cell line Open
To establish an inducible system for controlled ZBTB16 protein expression in a renal adenocarcinoma cell line. The Tet-On® 3G Inducible Expression System from Clontech was used to generate a tetracycline-regulated ZBTB16 expression system …
View article: The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF
The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF Open
To date, the activities of protein kinases have formed the core of our understanding of cell signal transduction. Comprehension of the extent of protein acetylation has raised expectations that this alternate post-transcriptional modificat…