Bangbei Wan
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View article: Melatonin biosynthesis and regulation in reproduction
Melatonin biosynthesis and regulation in reproduction Open
Melatonin, a neuroendocrine hormone widely present in animals, is a derivative of tryptophan secreted by the pineal gland. This hormone regulates animal circadian rhythms and can affect reproductive performance in many ways; for example, m…
View article: Comment on “Reproductive Outcomes of Transferring Blastocysts Derived From Frozen–Thawed Cleavage Embryos: A Systematic Review and Meta‐Analysis”
Comment on “Reproductive Outcomes of Transferring Blastocysts Derived From Frozen–Thawed Cleavage Embryos: A Systematic Review and Meta‐Analysis” Open
Tran et al. synthesized seven studies ( n = 2,057) comparing frozen–thawed cleavage embryos cultured to blastocyst then transferred (FT‐CDB) with direct frozen–thawed blastocyst transfer (DFB) in vitrification cycles. They found higher odd…
View article: Comment on “Sperm Injection at the Para‐Polar Body Site in Piezo‐Intracytoplasmic Sperm Injection Improves Subsequent Early Development of Bovine Embryos”
Comment on “Sperm Injection at the Para‐Polar Body Site in Piezo‐Intracytoplasmic Sperm Injection Improves Subsequent Early Development of Bovine Embryos” Open
Piezo‐intracytoplasmic sperm injection (piezo‐ICSI) is increasingly used to reduce mechanical damage during sperm injection. In the recent study by Ashibe et al., placing the first polar body (PB) at the 2 or 4 o'clock position (“para‐PB p…
View article: Comprehensive analysis of lysine lactylation and its potential biological significance in clear cell renal cell carcinoma
Comprehensive analysis of lysine lactylation and its potential biological significance in clear cell renal cell carcinoma Open
This study revealed the role of Kla in ccRCC, which will extend our understanding of the potential molecular mechanisms underlying ccRCC formation and progression. These key Kla-modified proteins may be promising therapeutic targets for th…
View article: Two-sample Mendelian randomization analysis of causal relationship between eczema and autoimmune diseases.
Two-sample Mendelian randomization analysis of causal relationship between eczema and autoimmune diseases. Open
Eczema is associated with an increased risk of Crohn's disease and ulcerative colitis. No causal relationship is found between eczema and SLE, MS, AS, RA, BP, or vitiligo.
View article: Mendelian randomization study of gastroesophageal reflux disease and major depression
Mendelian randomization study of gastroesophageal reflux disease and major depression Open
This study systematically investigated the causal relationship between gastroesophageal reflux disease (GERD) and major depression (MD). Single-nucleotide polymorphisms (SNPs) associated with disorders of interest were screened via the gen…
View article: The current landscape of m6A modification in urological cancers
The current landscape of m6A modification in urological cancers Open
N6-methyladenosine (m6A) methylation is a dynamic and reversible procession of epigenetic modifications. It is increasingly recognized that m6A modification has been involved in the tumorigenesis, development, and progression of urological…
View article: Modifiable risk factors of major depressive disorder: A Mendelian randomization study
Modifiable risk factors of major depressive disorder: A Mendelian randomization study Open
Identifying modifiable risk factors early on is essential to prevent major depressive disorder (MDD). This study systematically investigated the causal relationship between 19 modifiable risk factors and MDD. Single-nucleotide polymorphism…
View article: Putative causal inference for the relationship between obesity and sex hormones in males: a bidirectional Mendelian randomization study
Putative causal inference for the relationship between obesity and sex hormones in males: a bidirectional Mendelian randomization study Open
Background Obesity is a chronic disease with a high prevalence rate and is an established risk factor for human health. Body mass index (BMI) is a common and primary indicator used in assessing obesity. This work aims to investigate the pu…
View article: Effects of UBE3A on the insulin resistance in polycystic ovary syndrome through the ubiquitination of AMPK
Effects of UBE3A on the insulin resistance in polycystic ovary syndrome through the ubiquitination of AMPK Open
Background Polycystic ovary syndrome (PCOS) is a reproductive hormonal abnormality and a metabolic disorder, which is frequently associated with insulin resistance (IR). We aim to investigate the potential therapeutic effects of Ubiquitin-…
View article: Four modifiable factors that mediate the effect of educational time on major depressive disorder risk: A network Mendelian randomization study
Four modifiable factors that mediate the effect of educational time on major depressive disorder risk: A network Mendelian randomization study Open
Background Major depressive disorder (MDD) is a mental illness, which is a notable public health problem that aggravates the global economic burden. This study aimed to investigate the causal relationship between education and MDD risk and…
View article: Mendelian randomization study on the causal relationship between leukocyte telomere length and prostate cancer
Mendelian randomization study on the causal relationship between leukocyte telomere length and prostate cancer Open
Background Leukocyte telomere length (LTL) is related to prostate cancer (PCa). However, the causal relationship between them remains unknown. This study was aimed at identifying the causal direction between LTL and PCa with Mendelian rand…
View article: BAG3 as a novel prognostic biomarker in kidney renal clear cell carcinoma correlating with immune infiltrates
BAG3 as a novel prognostic biomarker in kidney renal clear cell carcinoma correlating with immune infiltrates Open
Purpose BCL-2-associated athanogene 3 (BAG3) is an anti-apoptotic protein that plays an essential role in the onset and progression of multiple cancer types. However, the clinical significance of BAG3 in kidney renal clear cell carcinoma (…
View article: Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study
Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study Open
Background Stroke is a common cerebrovascular disease with great danger to public health. Educational inequality is a universal issue that influences populations’ stroke risk. This study aimed to investigate the causal relationship between…
View article: Leukocyte telomere length and bipolar disorder risk: evidence from Mendelian randomization analysis
Leukocyte telomere length and bipolar disorder risk: evidence from Mendelian randomization analysis Open
Objective We aim to test whether leukocyte telomere length (LTL) is causally associated with the risk of bipolar disorder (BD) using the Mendelian randomization (MR) method. Methods Results of a genome-wide association study (GWAS) conduct…
View article: Evaluating the causal relationship between five modifiable factors and the risk of spinal stenosis: a multivariable Mendelian randomization analysis
Evaluating the causal relationship between five modifiable factors and the risk of spinal stenosis: a multivariable Mendelian randomization analysis Open
Background Spinal stenosis is a neurological disorder related to the compression of the spinal cord or nerve roots, and its incidence increases yearly. We aimed to use Mendelian randomization (MR) to investigate the causal relationship bet…
View article: Identifying effects of genetic obesity exposure on leukocyte telomere length using Mendelian randomization
Identifying effects of genetic obesity exposure on leukocyte telomere length using Mendelian randomization Open
Background Observational studies have shown that obesity is closely associated with leukocyte telomere length (LTL). However, the causal relationship between obesity and LTL remains unclear. This study investigated the causal relationship …
View article: Body mass index and the risk of basal cell carcinoma: evidence from Mendelian randomization analysis
Body mass index and the risk of basal cell carcinoma: evidence from Mendelian randomization analysis Open
Objective We aim to test whether body mass index (BMI) is causally associated with the risk of basal cell carcinoma (BCC) using Mendelian randomization (MR) analysis. Methods Single-nucleotide polymorphisms (SNPs) associated with four BMI-…
View article: Mendelian randomization investigation identified the causal relationship between body fat indexes and the risk of bladder cancer
Mendelian randomization investigation identified the causal relationship between body fat indexes and the risk of bladder cancer Open
Background Observational studies have suggested that obesity is associated with the risk of bladder cancer (BCa). However, their causal relationship remains unclear. This study aimed to prove the causal relationship between obesity and the…
View article: Additional file 1 of Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study
Additional file 1 of Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study Open
Additional file 1: Table S1. The detailed information on single-nucleotide polymorphisms for estimating the causal association between years of schooling and the risk of stroke. Table S2. The detailed information on single-nucleotide polym…
View article: Additional file 2 of Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study
Additional file 2 of Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study Open
Additional file 2: Table S10. Leave-one-out analysis of the causal relationship between years of schooling and the risk of stroke. Table S11. Leave-one-out analysis of the causal relationship between years of schooling and the risk of hype…
View article: Hypothyroidism has a protective causal association with hepatocellular carcinoma: A two-sample Mendelian randomization study
Hypothyroidism has a protective causal association with hepatocellular carcinoma: A two-sample Mendelian randomization study Open
Objective Observational studies suggest an association between hypothyroidism and the risk of hepatocellular carcinoma (HCC), but the causality and direction of these effects are still inconclusive. We aim to test whether hypothyroidism is…
View article: Peer Review #1 of "Progress of research into circular RNAs in urinary neoplasms (v0.1)"
Peer Review #1 of "Progress of research into circular RNAs in urinary neoplasms (v0.1)" Open
Circular RNAs (circRNAs) are a large class of endogenous RNA that form a covalently closed continuous loop without 5' or 3' tails and are diffusely expressed in mammalian cells.Through the development of high-throughput sequencing, microar…
View article: Progress of research into circular RNAs in urinary neoplasms
Progress of research into circular RNAs in urinary neoplasms Open
Circular RNAs (circRNAs) are a large class of endogenous RNA that form a covalently closed continuous loop without 5′ or 3′ tails and are diffusely expressed in mammalian cells. Through the development of high-throughput sequencing, microa…
View article: Identification of genes of prognostic value in the ccRCC microenvironment from TCGA database
Identification of genes of prognostic value in the ccRCC microenvironment from TCGA database Open
Background Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of renal cell carcinoma. Bioinformatics analyses were used to screen candidate genes associated with the prognosis and microenvironment of ccRCC and…
View article: Prognostic value of immune-related genes in clear cell renal cell carcinoma
Prognostic value of immune-related genes in clear cell renal cell carcinoma Open
Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of renal cell carcinoma, and immune-related genes (IRGs) are key contributors to its development. In this study, the gene expression profiles and clinical data…
View article: Differentially expressed autophagy-related genes are potential prognostic and diagnostic biomarkers in clear-cell renal cell carcinoma
Differentially expressed autophagy-related genes are potential prognostic and diagnostic biomarkers in clear-cell renal cell carcinoma Open
We examined the role of differentially expressed autophagy-related genes (DEARGs) in clear cell Renal Cell Carcinoma (ccRCC) using high-throughput RNA-seq data from The Cancer Genome Atlas (TCGA). Cox regression analyses showed that 5 DEAR…