Bangning Yu
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Author Swipe
View article: Data from First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors
Data from First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors Open
Purpose: ONC201 is a small-molecule selective antagonist of the G protein–coupled receptor DRD2 that is the founding member of the imipridone class of compounds. A first-in-human phase I study of ONC201 was conducted to determine it…
View article: Supplementary Figures 1-6, Supplementary Tables 1-5 from First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors
Supplementary Figures 1-6, Supplementary Tables 1-5 from First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors Open
'Figure S1: ONC201 doses versus (A) Cmax and (B) AUC determined after the first dose of ONC201.; Figure S2: Covariant analyses of pharmacokinetic parameters; Figure S3: Caspase-cleaved versus total cytokeratin 18 at baseline and 21 days fo…
View article: Data from First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors
Data from First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors Open
Purpose: ONC201 is a small-molecule selective antagonist of the G protein–coupled receptor DRD2 that is the founding member of the imipridone class of compounds. A first-in-human phase I study of ONC201 was conducted to determine it…
View article: Supplementary Figures 1-6, Supplementary Tables 1-5 from First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors
Supplementary Figures 1-6, Supplementary Tables 1-5 from First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors Open
'Figure S1: ONC201 doses versus (A) Cmax and (B) AUC determined after the first dose of ONC201.; Figure S2: Covariant analyses of pharmacokinetic parameters; Figure S3: Caspase-cleaved versus total cytokeratin 18 at baseline and 21 days fo…
View article: Serotonin 5-HT2A receptor activity mediates adipocyte differentiation through control of adipogenic gene expression
Serotonin 5-HT2A receptor activity mediates adipocyte differentiation through control of adipogenic gene expression Open
Serotonin 5-HT 2 receptors are expressed in many tissues and play important roles in biological processes. Although the 5-HT 2A receptor is primarily known for its role in central nervous system, it is also expressed in peripheral tissues.…
View article: DDEL-09. HIGH DOSE MTX110 (SOLUBLE PANOBINOSTAT) SAFELY ADMINISTERED INTO THE FOURTH VENTRICLE IN A NON-HUMAN PRIMATE MODEL
DDEL-09. HIGH DOSE MTX110 (SOLUBLE PANOBINOSTAT) SAFELY ADMINISTERED INTO THE FOURTH VENTRICLE IN A NON-HUMAN PRIMATE MODEL Open
OBJECTIVE This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma, UK) into the fourth ventricle of non-human primates. METHODS Four rhesus macaque monke…
View article: High-dose MTX110 (soluble panobinostat) safely administered into the fourth ventricle in a nonhuman primate model
High-dose MTX110 (soluble panobinostat) safely administered into the fourth ventricle in a nonhuman primate model Open
OBJECTIVE Chemotherapy infusions directly into the fourth ventricle may play a role in treating malignant fourth-ventricular tumors. This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (so…
View article: First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors
First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors Open
Purpose: ONC201 is a small-molecule selective antagonist of the G protein–coupled receptor DRD2 that is the founding member of the imipridone class of compounds. A first-in-human phase I study of ONC201 was conducted to determine its recom…