Bin He
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View article: Erianin Suppresses Pancreatic Cancer Progression by Inducing Cell Cycle Arrest and Ferroptosis
Erianin Suppresses Pancreatic Cancer Progression by Inducing Cell Cycle Arrest and Ferroptosis Open
Erianin exerts potent anti-tumor effects on pancreatic cancer cells by inducing cell cycle arrest and ferroptosis. These findings establish erianin as a promising therapeutic candidate for pancreatic cancer treatment.
View article: Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness
Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness Open
View article: Dynamic Sharing Algorithm for Power Grid Survey Data Based on Blockchain and Proxy Re-encryption
Dynamic Sharing Algorithm for Power Grid Survey Data Based on Blockchain and Proxy Re-encryption Open
View article: A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis Open
Background Ewing’s sarcoma (EWS) is a highly aggressive malignant tumor that originates from bone or soft tissue. To date, there is no established prognostic model for EWS tumor. This study aims to identify prognostic genes and develop a p…
View article: Deactivation mechanisms of Nb <sub>2</sub> O <sub>5</sub> catalyst for esterification of dimethyl adipate: crystal transformation and acid site coking
Deactivation mechanisms of Nb <sub>2</sub> O <sub>5</sub> catalyst for esterification of dimethyl adipate: crystal transformation and acid site coking Open
Nb 2 O 5 catalyst deactivation in adiponitrile synthesis is caused by carbon deposition and phase transformation. Proper acidity and site control boost selectivity, offering strategies for enhanced catalyst lifespan and efficiency.
View article: Improved Delaunay-triangulation-based 3D Geological Modelling Algorithm for Power Pylons
Improved Delaunay-triangulation-based 3D Geological Modelling Algorithm for Power Pylons Open
View article: miR-21-Mediated Endothelial Senescence and Dysfunction Are Involved in Cigarette Smoke-Induced Pulmonary Hypertension through Activation of PI3K/AKT/mTOR Signaling
miR-21-Mediated Endothelial Senescence and Dysfunction Are Involved in Cigarette Smoke-Induced Pulmonary Hypertension through Activation of PI3K/AKT/mTOR Signaling Open
Smoking is a pathogenic factor for pulmonary hypertension (PH). Our previous study showed that serum miR-21 levels are elevated in smokers. miR-21 is considered as engaged in the PH process; however, its mechanisms remain unclear. In this …
View article: Effect of brominated flame retardants exposure on liver function and the risk of non-alcoholic fatty liver disease in the US population
Effect of brominated flame retardants exposure on liver function and the risk of non-alcoholic fatty liver disease in the US population Open
BFR exposure may increase the risk of liver injury and NAFLD, with no significant association with AHF risk. The impact of BFR exposure on liver health should not be overlooked, especially in individuals residing in impoverished areas.
View article: Optimal Evcs Planning Via Spatial-Temporal Distribution of Charging Demand Forecasting and Traffic-Grid Coupling
Optimal Evcs Planning Via Spatial-Temporal Distribution of Charging Demand Forecasting and Traffic-Grid Coupling Open
View article: Circular RNA Expression Profiles Are Significantly Altered after Cerebral Ischemia‒Reperfusion Injury in Different Parts of the Rat Brain
Circular RNA Expression Profiles Are Significantly Altered after Cerebral Ischemia‒Reperfusion Injury in Different Parts of the Rat Brain Open
Purpose The objective of this study was to investigate the connection between circular RNA (circRNA) and ischemia-reperfusion (I/R) injury set on by middle cerebral artery occlusion (MCAO) in different parts of the rat brain. Methods Using…
View article: High efficacy of Azacitidine plus HAG in acute myeloid leukemia: an open-label, single-arm, multi-center, phase 2 study
High efficacy of Azacitidine plus HAG in acute myeloid leukemia: an open-label, single-arm, multi-center, phase 2 study Open
View article: Machine Learning-Based Prognostic Prediction Models of Non-Metastatic Colon Cancer: Analyses Based on Surveillance, Epidemiology and End Results Database and a Chinese Cohort
Machine Learning-Based Prognostic Prediction Models of Non-Metastatic Colon Cancer: Analyses Based on Surveillance, Epidemiology and End Results Database and a Chinese Cohort Open
Mo Tang,1 Lihao Gao,2 Bin He,1 Yufei Yang1 1Oncology Department, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2Smart City Business Unit, Baidu Inc., Beijing, People’s Republic of ChinaC…
View article: Ceramide Synthase 6 Mediates Triple-Negative Breast Cancer Response to Chemotherapy Through RhoA- and EGFR-Mediated Signaling Pathways
Ceramide Synthase 6 Mediates Triple-Negative Breast Cancer Response to Chemotherapy Through RhoA- and EGFR-Mediated Signaling Pathways Open
Our study is the first to demonstrate that CERS6 may serve as a treatment sensitivity biomarker in patients with TNBC in response to chemotherapy. In addition, our findings suggested that CERS6 may be a therapeutic target for TNBC treatmen…
View article: Prognostic value of lymphocyte-to-monocyte ratio and histone methyltransferase G9a histone methyltransferase in patients with double expression lymphoma
Prognostic value of lymphocyte-to-monocyte ratio and histone methyltransferase G9a histone methyltransferase in patients with double expression lymphoma Open
In patients with diffuse large B-cell lymphoma, MYC combined with Bcl2 and/or Bcl6-based protein expression is called double expression lymphoma (DEL). R-DA-EPOCH program chemotherapy is typically recommended because these patients often h…
View article: Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood–brain barrier during kainic acid-induced brain damage
Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood–brain barrier during kainic acid-induced brain damage Open
Rufinamide (RUF) is a structurally unique anti-epileptic drug, but its protective mechanism against brain injury remains unclear. In the present study, we validated how the RUF protected mice with kainic acid (KA)-induced neuronal damage. …
View article: WITHDRAWN: <i>MiR-760</i> inhibits the progression of non-small cell lung cancer through blocking <i> <i>ROS1</i> </i>/Ras/Raf/MEK/ERK pathway
WITHDRAWN: <i>MiR-760</i> inhibits the progression of non-small cell lung cancer through blocking <i> <i>ROS1</i> </i>/Ras/Raf/MEK/ERK pathway Open
The Accepted Manuscript version of this article (published on 29 April 2020) was withdrawn on 8 June 2020 due to concerns over authorship and data validity.
View article: Bone marrow-mesenchymal stem cells modulate microglial activation in the peri-infarct area in rats during the acute phase of stroke
Bone marrow-mesenchymal stem cells modulate microglial activation in the peri-infarct area in rats during the acute phase of stroke Open
The transplanted BM-MSCs exerted immunomodulatory effect by inactivating the microglias in the peri-infarct area, at least partially, via the CD200-CD200R1 signaling.
View article: Enterobactin-Specific Antibodies Induced by a Novel Enterobactin Conjugate Vaccine
Enterobactin-Specific Antibodies Induced by a Novel Enterobactin Conjugate Vaccine Open
Ent-mediated high-affinity iron acquisition is a universal and critical contributor for Gram-negative pathogens to survive and infect hosts. Published information has supported an innovative immune intervention strategy that directly targe…
View article: Effect of EGFR gene polymorphism on efficacy of chemotherapy combined with targeted therapy for non-small cell lung cancer in Chinese patients.
Effect of EGFR gene polymorphism on efficacy of chemotherapy combined with targeted therapy for non-small cell lung cancer in Chinese patients. Open
EGFR-TKI had become the first-line treatment of metastatic NSCLC and widely used in clinical. It was reported that there was difference in response rate between NSCLC patients with or without EGFR mutation. However, there was no relevant s…
View article: Recombinant human adenovirus‑p53 improves the outcome of mid‑late stage pancreatic cancer via arterial infusion
Recombinant human adenovirus‑p53 improves the outcome of mid‑late stage pancreatic cancer via arterial infusion Open
The present study aimed to investigate the therapeutic efficacy and clinical value of recombinant human adenovirus-p53 (rAd-p53) perfusion via the pancreatic artery for the treatment of mid-late stage pancreatic cancer. rAd-p53 (2×101…
View article: [Progress on clinical application of bevacizumab for the treatment of refractory cervical cancer].
[Progress on clinical application of bevacizumab for the treatment of refractory cervical cancer]. Open
Bevacizumab is increasingly used in recurrent, persistent or metastatic cervical cancer. The early retrospective case reports found that bevacizumab combined with 5-FU (including capecitabine) or paclitaxel was well tolerated and displayed…
View article: Cost-effectiveness of radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer
Cost-effectiveness of radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer Open
Radical radiotherapy would be a cost-effective method for FIGO stage IIB cervical cancer and would be favored in settings where resources are limited.
View article: Application of 1H NMR spectroscopy-based metabonomics to feces of cervical cancer patients with radiation-induced acute intestinal symptoms
Application of 1H NMR spectroscopy-based metabonomics to feces of cervical cancer patients with radiation-induced acute intestinal symptoms Open
View article: Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration.
Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration. Open
The Forkhead Box M1 (FOXM1) transcription factor plays important roles in tumorigenesis and tumor metastasis in multiple human carcinomas. However, the underlying mechanisms for FOXM1 function remain to be classified. In the present study,…