Banwari Agarwal
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View article: Comparing short‐term mortality between people with and without <scp>HIV</scp> admitted to the intensive care unit: A single‐centre matched cohort study (2000–2019)
Comparing short‐term mortality between people with and without <span>HIV</span> admitted to the intensive care unit: A single‐centre matched cohort study (2000–2019) Open
Objectives The survival rate of people with HIV admitted to intensive care units (ICUs) is approaching that of people without HIV. We conducted a matched‐cohort study of people with and without HIV admitted to ICU at a large hospital to co…
View article: Editorial: Decoding <scp>ACLF</scp>—Sub‐Phenotyping to Advance Precision Medicine in Acute‐On‐Chronic Liver Failure
Editorial: Decoding <span>ACLF</span>—Sub‐Phenotyping to Advance Precision Medicine in Acute‐On‐Chronic Liver Failure Open
View article: Non‐selective beta‐blocker is associated with reduced mortality in critically ill patients with cirrhosis: A real‐world study
Non‐selective beta‐blocker is associated with reduced mortality in critically ill patients with cirrhosis: A real‐world study Open
Summary Background Apart from direct portal pressure reduction, non‐selective beta‐blockers (NSBB) modulate inflammatory response, which could be beneficial in patients with acute decompensation (AD). We therefore aimed to evaluate the eff…
View article: Novel Therapeutic Approaches in Treatment of Acute-on-Chronic Liver Failure
Novel Therapeutic Approaches in Treatment of Acute-on-Chronic Liver Failure Open
Acute-on-chronic liver failure (ACLF), a clinical syndrome that can develop at any stage in the progression of cirrhotic liver disease, is characterized by an acute decompensation in liver function with associated multiorgan failure and hi…
View article: PB0096 Cytokines Profile of Severe COVID-19 does not Differ from ICU-Control
PB0096 Cytokines Profile of Severe COVID-19 does not Differ from ICU-Control Open
View article: PB0056 Predicting VTE and Mortality in COVID-19 by Receiver-Operating Characteristic (ROC) Analysis of Haemostatic and Inflammatory Biomarkers
PB0056 Predicting VTE and Mortality in COVID-19 by Receiver-Operating Characteristic (ROC) Analysis of Haemostatic and Inflammatory Biomarkers Open
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View article: Nebulized Recombinant Tissue Plasminogen Activator (rt-PA) for Acute COVID-19-Induced Respiratory Failure: An Exploratory Proof-of-Concept Trial
Nebulized Recombinant Tissue Plasminogen Activator (rt-PA) for Acute COVID-19-Induced Respiratory Failure: An Exploratory Proof-of-Concept Trial Open
Acute lung injury in COVID-19 results in diffuse alveolar damage with disruption of the alveolar-capillary barrier, coagulation activation, alveolar fibrin deposition and pulmonary capillary thrombi. Nebulized recombinant tissue plasminoge…
View article: Changes in short-term (in-ICU and in-hospital) mortality following intensive care unit admission in adults living with HIV: 2000–2019
Changes in short-term (in-ICU and in-hospital) mortality following intensive care unit admission in adults living with HIV: 2000–2019 Open
Objective: Limited data suggest intensive care unit (ICU) outcomes have improved in people with HIV (PWH). We describe trends in in-ICU/in-hospital mortality among PWH following admission to ICU in a single UK-based HIV referral centre, fr…
View article: Nebulized recombinant tissue plasminogen activator (rt-PA) for acute COVID-19-induced severe respiratory failure: an exploratory proof of concept trial
Nebulized recombinant tissue plasminogen activator (rt-PA) for acute COVID-19-induced severe respiratory failure: an exploratory proof of concept trial Open
Nebulized thrombolysis offers locally targeted therapy with potentially lower bleeding risk than systemic administration for coronavirus disease 2019 (COVID-19) respiratory failure. In a proof-of-concept safety study, adult patients with C…
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View article: Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure
Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure Open
View article: Estimating the risk of mortality attributable to recent late <scp>HIV</scp> diagnosis following admission to the intensive care unit: A single‐centre observational cohort study
Estimating the risk of mortality attributable to recent late <span>HIV</span> diagnosis following admission to the intensive care unit: A single‐centre observational cohort study Open
Objectives Despite improvements in survival of people with HIV admitted to the intensive care unit (ICU), late diagnosis continues to contribute to in‐ICU mortality. We quantify the population attributable fraction (PAF) of in‐ICU mortalit…
View article: Overt hepatic encephalopathy is an independent risk factor for de novo infection in cirrhotic patients with acute decompensation
Overt hepatic encephalopathy is an independent risk factor for de novo infection in cirrhotic patients with acute decompensation Open
Background The occurrence of overt hepatic encephalopathy (OHE) is associated with increased mortality. HE is commonly precipitated by infection, but whether HE predisposes to new infection is unclear. This study aimed to test if OHE predi…
View article: P076 A multi-centre, randomized controlled study, to evaluate the safety and performance of the DIALIVE liver dialysis device in patients with acute on chronic liver failure (ACLF) versus standard of care (SOC) (ALIVER Consortium)
P076 A multi-centre, randomized controlled study, to evaluate the safety and performance of the DIALIVE liver dialysis device in patients with acute on chronic liver failure (ACLF) versus standard of care (SOC) (ALIVER Consortium) Open
Background and Aims Treatment of ACLF is an unmet need. DIALIVE is a novel liver dialysis device that replaces dysfunctional albumin and removes PAMPs and DAMPs. This RCT tests the hypothesis that DIALIVE improves the prognosis of ACLF pat…
View article: P067 Outcomes in patients with acute liver failure treated with low volume plasma exchange: UK multicentre experience
P067 Outcomes in patients with acute liver failure treated with low volume plasma exchange: UK multicentre experience Open
Introduction Organ availability remains a barrier to successful management of patients with acute liver failure (ALF). Many patients have contra-indications to transplantation, leaving an ongoing unmet need for alternative and bridging the…
View article: P077 Pathophysiological basis of resolution of acute-on-chronic liver failure (ACLF) induced by the novel liver dialysis device, DIALIVE (ALIVER consortium)
P077 Pathophysiological basis of resolution of acute-on-chronic liver failure (ACLF) induced by the novel liver dialysis device, DIALIVE (ALIVER consortium) Open
Background In ACLF, systemic inflammation (SI) due to pathogen and damage associated molecular patterns (PAMPs and DAMPs), albumin and endothelial dysfunction results in organ failure. DIALIVE, a liver dialysis device replaces dysfunctiona…
View article: Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF
Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF Open
Background and Aims Patients with cirrhosis and acute-on-chronic liver failure (ACLF) have immunosuppression, indicated by an increase in circulating immune-deficient monocytes. The aim of this study was to investigate simultaneously the m…
View article: Management of acute liver failure in intensive care
Management of acute liver failure in intensive care Open
View article: Risk of mortality in patients with uncontrolled variceal bleeding is determined by the presence and severity of acute on chronic liver failure (ACLF) and early transjugular intrahepatic portosystemic shunt (TIPSS) reduces long term mortality
Risk of mortality in patients with uncontrolled variceal bleeding is determined by the presence and severity of acute on chronic liver failure (ACLF) and early transjugular intrahepatic portosystemic shunt (TIPSS) reduces long term mortality Open
View article: Refining the renal failure criteria of the EASL-CLIF diagnostic model for defining acute-on-chronic liver failure (ACLF)
Refining the renal failure criteria of the EASL-CLIF diagnostic model for defining acute-on-chronic liver failure (ACLF) Open
View article: Acute liver failure: updates in pathogenesis and management
Acute liver failure: updates in pathogenesis and management Open
View article: An Accurate Data Preparation Approach for the Prediction of Mortality in ACLF Patients using the CANONIC Dataset
An Accurate Data Preparation Approach for the Prediction of Mortality in ACLF Patients using the CANONIC Dataset Open
The incidence of chronic liver disease has increased in Europe and can lead to Acute on Chronic Liver Failure (ACLF) which is associated with high levels of mortality due to multisystem organ failure. The characteristics of the ACLF patien…
View article: Prothrombin Complex Concentrates for Coagulopathy in Liver Disease: Single‐Center, Clinical Experience in 105 Patients
Prothrombin Complex Concentrates for Coagulopathy in Liver Disease: Single‐Center, Clinical Experience in 105 Patients Open
Patients with liver disease frequently develop coagulopathy, and fresh frozen plasma is traditionally used for correction of coagulopathy to manage and prevent bleeding. Prothrombin complex concentrates (PCCs) offer an attractive alternati…
View article: Validation of CLIF-C ACLF score to define a threshold for futility of intensive care support for patients with acute-on-chronic liver failure
Validation of CLIF-C ACLF score to define a threshold for futility of intensive care support for patients with acute-on-chronic liver failure Open
Patients with ACLF and high CLIF-C ACLF score (≥ 70) after 48 hours of intensive care may reach a threshold of futility for further ongoing intensive support. The best treatment options in this scenario remain to be determined but may incl…
View article: Long‐term outcome in patients with acute liver failure
Long‐term outcome in patients with acute liver failure Open
Background & Aims Acute liver failure patients who meet poor prognostic criteria have high early mortality without emergency liver transplantation. A recent study however, reported that patients that survive spontaneously have a poorer out…
View article: Neurological Monitoring in Acute Liver Failure
Neurological Monitoring in Acute Liver Failure Open
View article: Development of an organ failure score in acute liver failure for transplant selection and identification of patients at high risk of futility
Development of an organ failure score in acute liver failure for transplant selection and identification of patients at high risk of futility Open
ALF-OFs is a new prognostic score in acetaminophen-related ALF that can predict both the need for liver transplant and high risk of transplant futility, improving candidate selection for liver transplantation.
View article: Acute kidney injury in acute-on-chronic liver failure: where does hepatorenal syndrome fit?
Acute kidney injury in acute-on-chronic liver failure: where does hepatorenal syndrome fit? Open
View article: Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs
Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs Open
View article: Erratum: The Royal Free Hospital Score: A Calibrated Prognostic Model for Patients With Cirrhosis Admitted to Intensive Care Unit. Comparison With Current Models and CLIF-SOFA Score
Erratum: The Royal Free Hospital Score: A Calibrated Prognostic Model for Patients With Cirrhosis Admitted to Intensive Care Unit. Comparison With Current Models and CLIF-SOFA Score Open
Theocharidou, Eleni; Pieri, Giulia; Mohammad, Ali Omar; Cheung, Michelle; Cholongitas, Evangelos; Banwari, Agarwal; Burroughs, Andrew K