Gang Peng
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View article: <i>Porphyromonas gingivalis</i> –Derived Virulence Lipids Accelerate Osteoclastogenesis Independently of High Mobility Group Box Protein‐1 Canonical Signaling
<i>Porphyromonas gingivalis</i> –Derived Virulence Lipids Accelerate Osteoclastogenesis Independently of High Mobility Group Box Protein‐1 Canonical Signaling Open
Periodontal bacterial pathogen‐associated molecular patterns (PAMPs) and damage‐associated molecular patterns (DAMPs) accelerate inflammatory osteoclastogenesis, resulting in alveolar bone loss. The core PAMP and DAMP prototype molecules a…
View article: Can transient neonatal osteosclerosis be differentiated from malignant infantile osteopetrosis?
Can transient neonatal osteosclerosis be differentiated from malignant infantile osteopetrosis? Open
Osteosclerosis in infancy requires careful evaluation as it may indicate the presence of osteopetrosis. Osteopetrosis is a rare disorder of high bone density due to impaired osteoclast resorption. Infantile forms of osteopetrosis have neur…
View article: Neighborhood Deprivation and Biological and Psychosocial Outcomes for Head and Neck Cancer
Neighborhood Deprivation and Biological and Psychosocial Outcomes for Head and Neck Cancer Open
This cohort study examines the association of neighborhood disadvantage with outcomes in patients with head and neck cancer.
View article: Temperature-effect incorporated damage assessment methodology for beam-slab composite structures subjected to long-duration blast loads
Temperature-effect incorporated damage assessment methodology for beam-slab composite structures subjected to long-duration blast loads Open
Aiming at addressing the issues of unclear dynamic response mechanisms and insufficient quantification of temperature coupling effects in building structures under long-duration blast loads, this study investigates typical composite beam-s…
View article: Carotid Stenosis as Stroke Risk Factor
Carotid Stenosis as Stroke Risk Factor Open
The study’s comprehensive analysis of carotid stenosis and its mechanisms highlights the critical role of atherosclerotic plaques in stroke development. By integrating detailed pathophysiological insights with the latest diagnostic and the…
View article: Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity
Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity Open
Single-nucleus RNA sequencing (snRNA-seq), an alternative to single-cell RNA sequencing (scRNA-seq), encounters technical challenges in obtaining high-quality nuclei and RNA, persistently hindering its applications. Here, we present a robu…
View article: PedBE age and age acceleration in umbilical vein endothelial cells: an examination of infant birth outcomes
PedBE age and age acceleration in umbilical vein endothelial cells: an examination of infant birth outcomes Open
The current study examines the application of the Pediatric-Buccal-Epigenetic (PedBE) clock, designed for buccal epithelial cells, to endothelia. We evaluate the association of PedBE epigenetic age and age acceleration estimated from human…
View article: Age-Related Patterns of DNA Methylation Changes
Age-Related Patterns of DNA Methylation Changes Open
Epigenetic clocks have achieved significant success in aging research, but they often assume linear methylation changes with age and lack biological interpretability. Using data from 4,641 samples across 23 GEO datasets, we analyzed 1,557 …
View article: BatchLLM: Optimizing Large Batched LLM Inference with Global Prefix Sharing and Throughput-oriented Token Batching
BatchLLM: Optimizing Large Batched LLM Inference with Global Prefix Sharing and Throughput-oriented Token Batching Open
Large language models (LLMs) increasingly play an important role in a wide range of information processing and management tasks. Many of these tasks are performed in large batches or even offline, and the performance indictor for which is …
View article: Robust single nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity
Robust single nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity Open
Single nucleus RNA sequencing (snRNA-seq), an alternative to single cell RNA sequencing (scRNA-seq), encounters technical challenges in obtaining high-quality nuclei and RNA, persistently hindering its applications. Here, we present a robu…
View article: Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity
Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity Open
Single-nucleus RNA sequencing (snRNA-seq), an alternative to single-cell RNA sequencing (scRNA-seq), encounters technical challenges in obtaining high-quality nuclei and RNA, persistently hindering its applications. Here, we present a robu…
View article: Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner
Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner Open
Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in bone from wildtype (WT) mice compared to mice l…
View article: Sex dimorphic response to osteocyte miR21 deletion in murine calvaria bone as determined by RNAseq analysis
Sex dimorphic response to osteocyte miR21 deletion in murine calvaria bone as determined by RNAseq analysis Open
Low levels of microRNA (miR) 21 may explain the higher osteocyte apoptosis with Cx43-deficient and aged female mice. However, miR21 exerts a sex-divergent role in osteocytes, regulating bone mass and architecture through non-cell autonomou…
View article: Robust single nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity
Robust single nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity Open
Single nucleus RNA sequencing (snRNA-seq), an alternative to single cell RNA sequencing (scRNA-seq), encounters technical challenges in obtaining high-quality nuclei and RNA, persistently hindering its applications. Here, we present a robu…
View article: Onyx prevent the bleeding of ruptured aneurysms during interventional embolization
Onyx prevent the bleeding of ruptured aneurysms during interventional embolization Open
Endovascular treatment has been acknowledged as an effective treatment for intracranial aneurysms, showcasing favorable clinical outcomes and providing robust protection against rebleeding and rupture. Notably, during the endovascular proc…
View article: Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner
Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner Open
Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in bone from wildtype (WT) mice compared to mice l…
View article: Author Response: Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner
Author Response: Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner Open
Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in bone from wildtype (WT) mice compared to mice l…
View article: LFSPROShiny: An Interactive R/Shiny App for Prediction and Visualization of Cancer Risks in Families With Deleterious Germline <i>TP53</i> Mutations
LFSPROShiny: An Interactive R/Shiny App for Prediction and Visualization of Cancer Risks in Families With Deleterious Germline <i>TP53</i> Mutations Open
PURPOSE LFSPRO is an R library that implements risk prediction models for Li-Fraumeni syndrome (LFS), a genetic disorder characterized by deleterious germline mutations in the TP53 gene. To facilitate the use of these models in clinics, we…
View article: Maternal childhood adversity and infant epigenetic aging: Moderation by restless sleep during pregnancy
Maternal childhood adversity and infant epigenetic aging: Moderation by restless sleep during pregnancy Open
Maternal exposure to childhood adversity is associated with detrimental health outcomes throughout the life span and may have implications for offspring. Evidence links maternal adverse childhood experiences (ACEs) to detrimental birth out…
View article: Osteoblast Transcriptome Changes During Iron Deficiency
Osteoblast Transcriptome Changes During Iron Deficiency Open
Introduction:Chronic kidney disease (CKD) often results in iron deficiency anemia and bone loss. Previously, iron deficiency was found to impede normal osteoblast differentiation. To investigate regulatory mechanisms elicited by iron defic…
View article: Reviewer #2 (Public Review): Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner
Reviewer #2 (Public Review): Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner Open
Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in bone from wildtype (WT) mice compared to mice l…