Bao-Peng Pu
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View article: Rapamycin suppresses small bowel adenocarcinoma HUTU 80 cells proliferation by inhibiting hypoxia-inducible factor-1α mediated metabolic reprogramming
Rapamycin suppresses small bowel adenocarcinoma HUTU 80 cells proliferation by inhibiting hypoxia-inducible factor-1α mediated metabolic reprogramming Open
BACKGROUND Small bowel adenocarcinoma (SBA) is a rare malignant tumor of gastrointestinal tract. Currently, there is no standard treatment approach for late-stage SBA, which lead to poor outcome and prognosis. Rapamycin is an immunosuppres…
View article: Rapamycin inhibits B16 melanoma cell viability <i>in</i> <i>vitro</i> and <i>in</i> <i>vivo</i> by inducing autophagy and inhibiting the mTOR/p70‑S6k pathway
Rapamycin inhibits B16 melanoma cell viability <i>in</i> <i>vitro</i> and <i>in</i> <i>vivo</i> by inducing autophagy and inhibiting the mTOR/p70‑S6k pathway Open
Rapamycin is an immunosuppressant that has been shown to prevent tumor growth following organ transplantation. However, its exact mode of antitumor action remains unknown. The present study used the B16-F10 (B16) murine melanoma model to e…