Baoan Chen
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View article: Progress in Multi-Performance Enhancement Technology of Heat-Resistant Aluminum Alloy Conductor
Progress in Multi-Performance Enhancement Technology of Heat-Resistant Aluminum Alloy Conductor Open
Al-Zr heat-resistant aluminum alloy conductor are widely used in large-capacity overhead conductors due to its excellent thermal stability, but there is a mutual constraint relationship between electric conductivity, heat resistance, and s…
View article: Effects of cooling rate in homogenization on microstructure, hot deformation resistance and subsequent age-hardening behavior of an Al–Mg–Si alloy
Effects of cooling rate in homogenization on microstructure, hot deformation resistance and subsequent age-hardening behavior of an Al–Mg–Si alloy Open
In this paper, the microstructure evolution in an Al–Mg–Si alloy during the soaking and cooling of homogenization was investigated. Moreover, the effects of the cooling rate on the hot deformation and subsequent age-hardening behavior were…
View article: Action Mechanism of Metformin and Its Application in Hematological Malignancy Treatments: A Review
Action Mechanism of Metformin and Its Application in Hematological Malignancy Treatments: A Review Open
Hematologic malignancies (HMs) mainly include acute and chronic leukemia, lymphoma, myeloma and other heterogeneous tumors that seriously threaten human life and health. The common effective treatments are radiotherapy, chemotherapy and he…
View article: HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia
HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia Open
HOTTIP lncRNA is highly expressed in acute myeloid leukemia (AML) driven by MLL rearrangements or NPM1 mutations to mediate HOXA topologically associated domain (TAD) formation and drive aberrant transcription. However, the mechanism throu…
View article: Tumor‐derived exosomal miR‐19b‐3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway
Tumor‐derived exosomal miR‐19b‐3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway Open
Numerous reports have elucidated the important participation of exosomes in the communication between tumor cells and other cancer‐related cells including tumor‐associated macrophages (TAMs) in microenvironment. However, the interchange of…
View article: CCAT1/FABP5 promotes tumour progression through mediating fatty acid metabolism and stabilizing PI3K/AKT/mTOR signalling in lung adenocarcinoma
CCAT1/FABP5 promotes tumour progression through mediating fatty acid metabolism and stabilizing PI3K/AKT/mTOR signalling in lung adenocarcinoma Open
Long non‐coding RNA (lncRNA) colon cancer associated transcript 1 (CCAT1) has been identified as an oncogene in many cancers, but its role in lung adenocarcinoma (LUAD) remains to be further investigated. We identified the upregulation of …
View article: Human cytomegalovirus infection: A considerable issue following allogeneic hematopoietic stem cell transplantation (Review)
Human cytomegalovirus infection: A considerable issue following allogeneic hematopoietic stem cell transplantation (Review) Open
Cytomegalovirus (CMV) is an opportunistic virus, whereby recipients are most susceptible following allogeneic hematopoietic stem cell transplantation (allo-HSCT). With the development of novel immunosuppressive agents and antiviral drugs, …
View article: Progress of Breast Cancer basic research in China
Progress of Breast Cancer basic research in China Open
Breast cancer is the most commonly diagnosed and the most lethal cancer in females both in China and worldwide. Currently, the origin of cancer stem cells, the heterogeneity of cancer cells, the mechanism of cancer metastasis and drug resi…
View article: Prognostic significance of ferroptosis-related genes and their methylation in AML
Prognostic significance of ferroptosis-related genes and their methylation in AML Open
AKR1C2 and SOCS1 are promising biomarkers for predicting prognosis in patients with AML.
View article: <p>A Review of Biomimetic Nanoparticle Drug Delivery Systems Based on Cell Membranes</p>
A Review of Biomimetic Nanoparticle Drug Delivery Systems Based on Cell Membranes Open
Cancers have always been an intractable problem because of recurrence and drug resistance. In the past few decades, nanoparticles have been explored intensely to diagnose, prevent and treat malignancy due to their good penetrability and be…
View article: COVID-19 Transmission Within a Family Cluster in Yancheng, China
COVID-19 Transmission Within a Family Cluster in Yancheng, China Open
We report the clinical features of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a family setting of 13 people with person-to-person transmission in Yancheng, …
View article: TfR mAb-Cross-Linked Rituximab/MTX-PEG-PLL-PLGA Drug-Loaded Nanoparticles Enhance Anticancer Action in B Lymphocytes
TfR mAb-Cross-Linked Rituximab/MTX-PEG-PLL-PLGA Drug-Loaded Nanoparticles Enhance Anticancer Action in B Lymphocytes Open
Nanoparticles could enhance the drug targeted to the cancer cell by the enrichment of the drug levels, which leads to the improvement of the codelivery of both drugs for an antitumor effect. In the current study, we reported an efficient, …
View article: <p>Applications of daunorubicin-loaded PLGA-PLL-PEG-Tf nanoparticles in hematologic malignancies: an in vitro and in vivo evaluation</p>
Applications of daunorubicin-loaded PLGA-PLL-PEG-Tf nanoparticles in hematologic malignancies: an in vitro and in vivo evaluation Open
DNR-loaded NPs had a spherical shape of about 180 nm in diameter. DNR-loaded NP group showed a significant enhancement of cellular uptake in K562 cells compared with DNR group. Tumor inhibition rate was higher in DNR-loaded NP group in com…
View article: <p>Combination of drugs and carriers in drug delivery technology and its development</p>
Combination of drugs and carriers in drug delivery technology and its development Open
The development of drug-loading technology will bring new and rapid development to the treatment of diseases. At present, drug delivery by nanoparticles, erythrocyte, and platelet have been studied extensively. Compared with traditional an…
View article: Preparation and Mechanical Property of Graphene-reinforced Copper Matrix Composites
Preparation and Mechanical Property of Graphene-reinforced Copper Matrix Composites Open
Graphene, which has two-dimensional carbon single atomic layer, attracts great attention due to its superb mechanical, electrical and thermal properties.In addition to its excellent mechanical properties, a large surface area (about 2600 m…
View article: CVD Synthesis of Monodisperse Graphene/Cu Microparticles with High Corrosion Resistance in Cu Etchant
CVD Synthesis of Monodisperse Graphene/Cu Microparticles with High Corrosion Resistance in Cu Etchant Open
Copper powder has broad applications in the powder metallurgy, heat exchanger, and electronic industries due to its intrinsically high electrical and thermal conductivities. However, the ease of formation of surface oxide or patina layer r…
View article: CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia
CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia Open
Key Points CRISPR-Cas9 library screening identifies CBS7/9 boundary that defines an aberrant HOXA chromatin domain and HOX gene transcription in AML. Attenuation of CBS7/9 boundary impairs the leukemic transcription program and attenuates …
View article: Evaluation of latent membrane protein 1 and microRNA‑155 for the prognostic prediction of diffuse large B cell lymphoma
Evaluation of latent membrane protein 1 and microRNA‑155 for the prognostic prediction of diffuse large B cell lymphoma Open
Diffuse large B cell lymphoma (DLBCL) has previously been demonstrated to contribute to the mortality of lymphoma with various aggressive features. The prognostic role of the biomarkers latent membrane protein (LMP) 1 and microRNA-(miR)-15…
View article: Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy
Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy Open
Chemotherapy is still one of the main cancer therapy treatments, but the curative effect of chemotherapy is relatively low, as such the development of a new cancer treatment is highly desirable. The gradual maturation of nanotechnology pro…
View article: Hydrogel based 3D carriers in the application of stem cell therapy by direct injection
Hydrogel based 3D carriers in the application of stem cell therapy by direct injection Open
Compared with systematic administration such as peripheral intravenous infusion, stem cell therapy by direct injection is theoretically more effective, but some technical barriers such as low stem cell retention rate and low engraftment ra…
View article: β-Elemene: Mechanistic Studies on Cancer Cell Interaction and Its Chemosensitization Effect
β-Elemene: Mechanistic Studies on Cancer Cell Interaction and Its Chemosensitization Effect Open
Over the past decade, screening and identifying novel compounds for their biomedical applications has become an upcoming area of research. Identifying the molecular mechanisms of these compounds has become an integral part of anticancer re…
View article: Correction: Corrigendum: Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia
Correction: Corrigendum: Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia Open
Scientific Reports 6: Article number: 38004; published online: 25 November 2016 updated: 11 January 2017. This Article contains an error in Figure 1A, where the y-axis ‘Relative DNM2 level’ is incorrectly labelled as ‘Relative CRLF2 level’…
View article: Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy
Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy Open
The Cur-coordinated nanoparticles developed in this study improved Cur stability, which could further release Cur in a ROS-dependent manner in cancer cells.