Baocheng Chang
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View article: Development and validation of a risk prediction model for multidrug-resistant organisms infection in diabetic foot ulcer patients
Development and validation of a risk prediction model for multidrug-resistant organisms infection in diabetic foot ulcer patients Open
Objective To develop and validate a nomogram for predicting the risk of multidrug-resistant organisms (MDROs) infection in diabetic foot ulcer (DFU) patients. Methods 701 DFU patients were divided into training (491 cases) and validation (…
View article: Innovations in Pain Management: From Traditional Analgesics to Novel Therapeutic Modalities
Innovations in Pain Management: From Traditional Analgesics to Novel Therapeutic Modalities Open
Pain medicine has demonstrated its significance from brief surgical procedures to managing chronic illnesses. Historically, a range of analgesic and opioid agents have been utilized as treatment options, and although effective to a certain…
View article: Machine learning prediction of obesity-associated gut microbiota: identifying Bifidobacterium pseudocatenulatum as a potential therapeutic target
Machine learning prediction of obesity-associated gut microbiota: identifying Bifidobacterium pseudocatenulatum as a potential therapeutic target Open
Background The rising prevalence of obesity and related metabolic disorders highlights the urgent need for innovative research approaches. Utilizing machine learning (ML) algorithms to predict obesity-associated gut microbiota and validati…
View article: Effect of semaglutide on primary prevention of diabetic kidney disease in people with type 2 diabetes: A post hoc analysis of the SUSTAIN 6 randomized controlled trial
Effect of semaglutide on primary prevention of diabetic kidney disease in people with type 2 diabetes: A post hoc analysis of the SUSTAIN 6 randomized controlled trial Open
Aim Efficient primary prevention of diabetic kidney disease (DKD) is currently lacking. The identification of people at high DKD risk and timely intervention are key to preventing DKD. Therefore, a model to classify people according to the…
View article: Alterations of urine microRNA-7977/G6PD level in patients with diabetic kidney disease and its association with dysfunction of albumin-induced autophagy in proximal epithelial tubular cells
Alterations of urine microRNA-7977/G6PD level in patients with diabetic kidney disease and its association with dysfunction of albumin-induced autophagy in proximal epithelial tubular cells Open
This study provides new evidence that reduced glucose-6-phosphate dehydrogenase (G6PD) may damage the endocytosis of renal tubular epithelial cells by reducing albumin-induced autophagy. More importantly, for the first time, our study has …
View article: Amide proton transfer weighted contrast has diagnostic capacity in detecting diabetic foot: an MRI-based case–control study
Amide proton transfer weighted contrast has diagnostic capacity in detecting diabetic foot: an MRI-based case–control study Open
Objective To evaluate the role of foot muscle amide proton transfer weighted (APTw) contrast and tissue rest perfusion in quantifying diabetic foot (DF) infection and its correlation with blood parameters. Materials and methods With approv…
View article: A J‐shaped relationship between ketones and the risk of diabetic kidney disease in patients with type 2 diabetes: New insights from a cross‐sectional study
A J‐shaped relationship between ketones and the risk of diabetic kidney disease in patients with type 2 diabetes: New insights from a cross‐sectional study Open
Aim To investigate the association between circulating β‐hydroxybutyric acid (βOHB) and diabetic kidney disease (DKD) risk in patients with type 2 diabetes (T2D). Materials and Methods A total of 1388 patients with T2D were recruited. Part…
View article: Identifying optimal ranges of weight gain at the end of the second trimester result from a population-based cohort study
Identifying optimal ranges of weight gain at the end of the second trimester result from a population-based cohort study Open
Objective: To identify the optimal weight gain at the end of the second trimester. Design: This was a population-based cohort study from the antenatal care system in Tianjin, China. We calculated gestational weight gain (GWG) based on the …
View article: Preliminary study of metabonomics in patients with early and late onset type 2 diabetes mellitus based on UPLC-Q-TOF/MS: an observational study
Preliminary study of metabonomics in patients with early and late onset type 2 diabetes mellitus based on UPLC-Q-TOF/MS: an observational study Open
Aim: Non-targeted metabonomic techniques were used to explore changes in the metabolic profiles of patients with early onset and late onset T2DM. Main Methods: Newly diagnosed early onset T2DM (EarT2DM) and late onset T2DM (LatT2DM) patien…
View article: Editorial: Rising stars in renal endocrinology: 2021
Editorial: Rising stars in renal endocrinology: 2021 Open
EDITORIAL article Front. Endocrinol., 02 March 2023Sec. Renal Endocrinology Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1159850
View article: Urine Immunoglobin G Greater Than 2.45 mg/L Has a Correlation with the Onset and Progression of Diabetic Kidney Disease: A Retrospective Cohort Study
Urine Immunoglobin G Greater Than 2.45 mg/L Has a Correlation with the Onset and Progression of Diabetic Kidney Disease: A Retrospective Cohort Study Open
Aim: To further assess the correlation between urine immunoglobin G (IgG) greater than 2.45 mg/L and the onset and progression of diabetic kidney disease (DKD). Methods: One thousand and thirty-five patients with type 2 diabetes mellitus (…
View article: Establishment and validation of the cut-off values of estimated glomerular filtration rate and urinary albumin-to-creatinine ratio for diabetic kidney disease: A multi-center, prospective cohort study
Establishment and validation of the cut-off values of estimated glomerular filtration rate and urinary albumin-to-creatinine ratio for diabetic kidney disease: A multi-center, prospective cohort study Open
Objective We aimed to study the cut-off values of estimated glomerular filtration rate (eGFR) and the urinary albumin creatinine ratio (UACR) in the normal range for diabetic kidney disease (DKD). Methods In this study, we conducted a retr…
View article: Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway
Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway Open
Aim. Patients with diabetic ketosis often exhibit albuminuria. We previously found that acute hyperglycaemia can cause nephrotoxic injury. Here, we explored whether an excessive ketone body level causes kidney injury and the potential unde…
View article: Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway
Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway Open
Objective To investigate the effects and mechanism of hyperinsulinemia on the metabolic switch to β‐hydroxybutyrate (BHB) absorption and utilization under a starvation or hypoxic environment in proximal tubular epithelial cells. Methods A …
View article: Sex-specific mediating effect of gestational weight gain between pre-pregnancy body mass index and gestational diabetes mellitus
Sex-specific mediating effect of gestational weight gain between pre-pregnancy body mass index and gestational diabetes mellitus Open
Background Inappropriate weight gain may increase the risk of gestational diabetes mellitus (GDM). However, the relationship between pre-pregnancy body mass index (BMI), weight gain, and GDM has not been precisely quantified. This study ai…
View article: Peer Review #1 of "Predicting population: development and validation of a new predictive nomogram for evaluating medication nonadherence risk in a type 2 diabetes (v0.1)"
Peer Review #1 of "Predicting population: development and validation of a new predictive nomogram for evaluating medication nonadherence risk in a type 2 diabetes (v0.1)" Open
Background.Diabetes mellitus is a growing global health challenge and affects patients of all ages.Treatment aims to keep blood glucose levels close to normal and to prevent or delay complications.However, adherence to antidiabetic medicin…
View article: Predicting population: development and validation of a new predictive nomogram for evaluating medication nonadherence risk in a type 2 diabetes
Predicting population: development and validation of a new predictive nomogram for evaluating medication nonadherence risk in a type 2 diabetes Open
Background Diabetes mellitus is a growing global health challenge and affects patients of all ages. Treatment aims to keep blood glucose levels close to normal and to prevent or delay complications. However, adherence to antidiabetic medic…
View article: Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy
Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy Open
Aims. We investigated the changes of retinal structure in normal glucose tolerance (NGT), impaired glucose tolerance (IGT), diabetes mellitus (DM), and diabetic kidney disease (DKD) stages in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.…
View article: Metformin Inhibits the Phenotypic Transformation of Aortic Vascular Smooth Muscle Cells Induced by Hyperglycemia Through Regulation of the Mir-21-mediated PTEN/pAKT/Egr-1 Pathway
Metformin Inhibits the Phenotypic Transformation of Aortic Vascular Smooth Muscle Cells Induced by Hyperglycemia Through Regulation of the Mir-21-mediated PTEN/pAKT/Egr-1 Pathway Open
Background The phenotypic transformation of arterial vascular smooth muscle cells (VSMC) is one of the key mechanisms in the formation of atherosclerotic plaque. It is unclear whether metformin can inhibit the phenotypic transformation of …
View article: Pathological Hyperinsulinemia and Hyperglycemia in the Impaired Glucose Tolerance Stage Mediate Endothelial Dysfunction Through miR-21, PTEN/AKT/eNOS, and MARK/ET-1 Pathways
Pathological Hyperinsulinemia and Hyperglycemia in the Impaired Glucose Tolerance Stage Mediate Endothelial Dysfunction Through miR-21, PTEN/AKT/eNOS, and MARK/ET-1 Pathways Open
Background Impaired glucose tolerance (IGT) is an important prediabetic stage characterized by elevated concentrations of glucose and insulin in the blood. The pathological hyperglycemia and hyperinsulinemia in IGT may regulate the express…
View article: Vildagliptin Attenuates Myocardial Dysfunction and Restores Autophagy via miR-21/SPRY1/ERK in Diabetic Mice Heart
Vildagliptin Attenuates Myocardial Dysfunction and Restores Autophagy via miR-21/SPRY1/ERK in Diabetic Mice Heart Open
Aim: Vildagliptin (vild) improves diastolic dysfunction and is associated with a lower relative risk of major adverse cardiovascular events in younger patients. The present study aimed to evaluate whether vild prevents the development of d…
View article: Different Appearance of Chest CT Images of T2DM and NDM Patients with COVID-19 Pneumonia Based on an Artificial Intelligent Quantitative Method
Different Appearance of Chest CT Images of T2DM and NDM Patients with COVID-19 Pneumonia Based on an Artificial Intelligent Quantitative Method Open
COVID-19 is a kind of pneumonia with new coronavirus infection, and the risk of death in COVID-19 patients with diabetes is four times higher than that in healthy people. It is unclear whether there is a difference in chest CT images betwe…
View article: High urinary excretion rate of glucose attenuates serum uric acid level in type 2 diabetes with normal renal function
High urinary excretion rate of glucose attenuates serum uric acid level in type 2 diabetes with normal renal function Open
Aims/Introduction The relationship between urinary excretion rate of glucose (UEGL) and uric acid (UA) metabolism in adults with type 2 diabetes (T2D) remains unclear to date. This study aimed to investigate the relationships of UEGL with …
View article: Acute Hyperglycemia May Induce Renal Tubular Injury Through Mitophagy Inhibition
Acute Hyperglycemia May Induce Renal Tubular Injury Through Mitophagy Inhibition Open
Aim Acute hyperglycemia is closely related to kidney injury. Oxidative stress activation and notable mitochondria damages were found under acute hyperglycemia treatment in our previous work. In the present study, we explored the dose-effec…
View article: Preventive Role of Salsalate in Diabetes Is Associated With Reducing Intestinal Inflammation Through Improvement of Gut Dysbiosis in ZDF Rats
Preventive Role of Salsalate in Diabetes Is Associated With Reducing Intestinal Inflammation Through Improvement of Gut Dysbiosis in ZDF Rats Open
A safe and effective approach is needed to prevent and reduce the incidence of diabetes worldwide. The hypoglycemic efficacy of salicylic acid (salsalate, SAL), which has anti-inflammatory properties, has been empirically demonstrated in s…
View article: Analysis of factors related to diabetic retinopathy in patients with newly diagnosed type 2 diabetes: a cross-sectional study
Analysis of factors related to diabetic retinopathy in patients with newly diagnosed type 2 diabetes: a cross-sectional study Open
Aim To investigate the related factors of diabetic retinopathy (DR) and explore the correlation between smoking and DR in patients with newly diagnosed type 2 diabetes mellitus (T2DM). Design A single-centre cross-sectional study. Setting …
View article: Hyperinsulinemia contributes to impaired-glucose-tolerance-induced renal injury <i>via</i> mir-7977/SIRT3 signaling
Hyperinsulinemia contributes to impaired-glucose-tolerance-induced renal injury <i>via</i> mir-7977/SIRT3 signaling Open
Background: Increasing evidence indicates that impaired glucose tolerance (IGT) is independently associated with chronic kidney disease, but the characteristics and underlying mechanisms remain largely unknown. Methods: Here, the cross-sec…