Ben Wan
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View article: Diagnostic Value of Rapid On‐Site Evaluation Combined With Prostate Biopsy in Prostate Cancer
Diagnostic Value of Rapid On‐Site Evaluation Combined With Prostate Biopsy in Prostate Cancer Open
Objective To investigate the application value of Rapid On‐Site Evaluation (ROSE) in prostate biopsy. Methods All consecutive subjects who attended our clinic to underwent magnetic resonance imaging (MRI)‐ultrasound fusion biopsy due to hi…
View article: LINS: A general medical Q&A framework for enhancing the quality and credibility of LLM-generated responses
LINS: A general medical Q&A framework for enhancing the quality and credibility of LLM-generated responses Open
Large language models can lighten the workload of clinicians and patients, yet their responses often include fabricated evidence, outdated knowledge, and insufficient medical specificity. We introduce a general retrieval-augmented question…
View article: Chinese Pulsar Timing Array upper limits on microhertz gravitational waves from supermassive black-hole binaries using PSR J1713+0747 FAST data
Chinese Pulsar Timing Array upper limits on microhertz gravitational waves from supermassive black-hole binaries using PSR J1713+0747 FAST data Open
We derive the gravitational-wave (GW) strain upper limits from resolvable supermassive black-hole binaries using the data from the Five-hundred-meter Aperture Spherical radio Telescope (FAST), in the context of the Chinese Pulsar Timing Ar…
View article: Pruning for Sparse Diffusion Models based on Gradient Flow
Pruning for Sparse Diffusion Models based on Gradient Flow Open
Diffusion Models (DMs) have impressive capabilities among generation models, but are limited to slower inference speeds and higher computational costs. Previous works utilize one-shot structure pruning to derive lightweight DMs from pre-tr…
View article: Breast cancer and neoplasms of the thyroid gland: a bidirectional two-sample Mendelian randomization study
Breast cancer and neoplasms of the thyroid gland: a bidirectional two-sample Mendelian randomization study Open
Background With the rising incidence of breast cancer (BC) and neoplasms of the thyroid gland, a potential link between the two has drawn increasing attention. However, the causal relationship remains unclear due to various confounding fac…
View article: Darolutamide in Combination With Androgen-Deprivation Therapy in Patients With Metastatic Hormone-Sensitive Prostate Cancer From the Phase III ARANOTE Trial
Darolutamide in Combination With Androgen-Deprivation Therapy in Patients With Metastatic Hormone-Sensitive Prostate Cancer From the Phase III ARANOTE Trial Open
PURPOSE For patients with metastatic hormone-sensitive prostate cancer (mHSPC), delaying progression to castration-resistant disease is important not only for overall survival (OS) but also for patients' quality of life. Darolutamide plus …
View article: Carboxypeptidase E is a prognostic biomarker co-expressed with osteoblastic genes in osteosarcoma
Carboxypeptidase E is a prognostic biomarker co-expressed with osteoblastic genes in osteosarcoma Open
Osteosarcoma (OS) is a rare primary malignant bone tumor in adolescents and children with a poor prognosis. The identification of prognostic genes lags far behind advancements in treatment. In this study, we identified differential genes u…
View article: Regulation of hypoxic stress and oxidative stress in bone grafting: Current trends and future perspectives
Regulation of hypoxic stress and oxidative stress in bone grafting: Current trends and future perspectives Open
Tissue engineering aims to offer large-scale replacement of damaged organs using implants with the combination of cells, growth factors and scaffolds. However, the intra/peri‑implant region is exposed to severe hypoxic stress and oxidative…
View article: Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications
Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications Open
Treatment of bone defects remains a challenge in the clinic. Artificial bone grafts are the most promising alternative to autologous bone grafting. However, one of the limiting factors of artificial bone grafts is the limited means of regu…
View article: Analysis of Immune Gene Expression Subtypes Reveals Osteosarcoma Immune Heterogeneity
Analysis of Immune Gene Expression Subtypes Reveals Osteosarcoma Immune Heterogeneity Open
Background. Osteosarcoma (OS) patients have a poor response to immunotherapy due to the sheer complexity of the immune system and the nuances of the tumor-immune microenvironment. Methodology. To gain insights into the immune heterogeneity…
View article: Correction: Anti-osteosarcoma effect of hydroxyapatite nanoparticles both <i>in vitro</i> and <i>in vivo</i> by downregulating the FAK/PI3K/Akt signaling pathway
Correction: Anti-osteosarcoma effect of hydroxyapatite nanoparticles both <i>in vitro</i> and <i>in vivo</i> by downregulating the FAK/PI3K/Akt signaling pathway Open
Correction for ‘Anti-osteosarcoma effect of hydroxyapatite nanoparticles both in vitro and in vivo by downregulating the FAK/PI3K/Akt signaling pathway’ by Renxian Wang et al., Biomater. Sci., 2020, 8, 4426–4437, DOI: 10.1039/D0BM00898B.
View article: Building Osteogenic Microenvironments With Strontium-Substituted Calcium Phosphate Ceramics
Building Osteogenic Microenvironments With Strontium-Substituted Calcium Phosphate Ceramics Open
Bioceramics have experienced great development over the past 50 years. Modern bioceramics are designed to integrate bioactive ions within ceramic granules to trigger living tissue regeneration. Preclinical and clinical studies have shown t…
View article: Therapeutic Potential of Circular RNAs in Osteosarcoma
Therapeutic Potential of Circular RNAs in Osteosarcoma Open
Osteosarcoma is the most common malignant bone tumor in children and adolescents. Multiagent chemotherapy, together with surgical removal of all detectable lesions, has improved the long-term survival rate to 65-70% in patients with locali…
View article: Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser
Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser Open
The occurrence of lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH) is a common problem with a high incidence in the aging male population. Although it is not a life-threatening disease, BPH causes problems t…
View article: Photoselective Vaporesection of the Prostate with an End-firing Lithium Triborate Crystal Laser
Photoselective Vaporesection of the Prostate with an End-firing Lithium Triborate Crystal Laser Open
The PVRP technique demonstrates satisfactory short-term clinical outcomes and perioperative safety in the treatment of BPH.
View article: Evaluation of the Prostate Imaging Reporting and Data System for Magnetic Resonance Imaging Diagnosis of Prostate Cancer in Patients with Prostate-specific Antigen <20 ng/ml
Evaluation of the Prostate Imaging Reporting and Data System for Magnetic Resonance Imaging Diagnosis of Prostate Cancer in Patients with Prostate-specific Antigen <20 ng/ml Open
The PI-RADS score correlates with the PCa detection rate in patients with PSA <20 ng/ml. The summed score of T2WI + DWI has the highest accuracy in detection of PCa. However, the sensitivity should be further improved.
View article: Low-level Ki-67 expression as an independent predictor of bladder tumour recurrence in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy
Low-level Ki-67 expression as an independent predictor of bladder tumour recurrence in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy Open
Low-level Ki-67 expression was an independent predictor for bladder tumour recurrence, while Ki-67 overexpression was associated with adverse clinicopathological parameters and poor prognosis in patients with primary upper tract urothelial…