Baoli Yang
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View article: Bunyaviral Cap-Snatching Endonuclease Activity and Inhibition with Baloxavir-like Inhibitors in the Context of Full-Length L Proteins
Bunyaviral Cap-Snatching Endonuclease Activity and Inhibition with Baloxavir-like Inhibitors in the Context of Full-Length L Proteins Open
The Bunyavirales order includes a range of zoonotic viruses, which can cause severe disease in humans. The viral replication machinery is a logical target for the development of direct-acting antivirals. Inhibition of the cap-snatching end…
View article: Associations of cathepsins with pulmonary arterial hypertension mediated by circulating metabolites: A Mendelian randomization study
Associations of cathepsins with pulmonary arterial hypertension mediated by circulating metabolites: A Mendelian randomization study Open
The correlation between cathepsins and pulmonary arterial hypertension (PAH) is well-established, but the causative link between them remains uncertain. This study aimed to explore the causal role of circulating metabolites mediating cathe…
View article: Genome-Wide Identification of FCS-Like Zinc Finger (FLZ) Family Genes in Three Brassica Plant Species and Functional Characterization of BolFLZs in Chinese Kale Under Abiotic Stresses
Genome-Wide Identification of FCS-Like Zinc Finger (FLZ) Family Genes in Three Brassica Plant Species and Functional Characterization of BolFLZs in Chinese Kale Under Abiotic Stresses Open
FCS-like zinc finger (FLZ) proteins are plant-specific regulatory proteins, which contain a highly conserved FLZ domain, and they play critical roles in plant growth and stress responses. Although the FLZ family has been systematically cha…
View article: T-cell specific avian TdT: characterization of the cDNA and recombinant enzyme
T-cell specific avian TdT: characterization of the cDNA and recombinant enzyme Open
A cDNA clone coding for avian terminal deoxy-nucleotidyl transferase (TdT) has been isolated and sequenced. The size of this cDNA was 2545 bp with an open reading frame of 1521 bp and a predicted translation product of 58 kDa. Comparison o…
View article: Identification of a tripartite basal promoter which regulates human terminal deoxynucleotidyl transferase gene expression.
Identification of a tripartite basal promoter which regulates human terminal deoxynucleotidyl transferase gene expression. Open
In order to locate the promoter region of the human terminal deoxynucleotidyl transferase gene, serially truncated segments of the 5'-flanking region of the gene were cloned into a chloramphenicol acetyltransferase reporter vector. Transie…
View article: Loss of mXinα, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects
Loss of mXinα, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects Open
The intercalated disk protein Xin was originally discovered in chicken striated muscle and implicated in cardiac morphogenesis. In the mouse, there are two homologous genes, mXinα and mXinβ. The human homolog of mXinα, Cmya1, maps to chrom…
View article: Crowd counting via Multi-Scale Adversarial Convolutional Neural Networks
Crowd counting via Multi-Scale Adversarial Convolutional Neural Networks Open
The purpose of crowd counting is to estimate the number of pedestrians in crowd images. Crowd counting or density estimation is an extremely challenging task in computer vision, due to large scale variations and dense scene. Current method…
View article: The Role of Intercalated Cell Nedd4–2 in BP Regulation, Ion Transport, and Transporter Expression
The Role of Intercalated Cell Nedd4–2 in BP Regulation, Ion Transport, and Transporter Expression Open
Background Nedd4–2 is an E3 ubiquitin-protein ligase that associates with transport proteins, causing their ubiquitylation, and then internalization and degradation. Previous research has suggested a correlation between Nedd4–2 and BP. In …
View article: Generation and characterization of a conditional allele of <i>Interferon Regulatory Factor 6</i>
Generation and characterization of a conditional allele of <i>Interferon Regulatory Factor 6</i> Open
Summary Interferon Regulatory Factor 6 (IRF6) is a critical regulator of differentiation, proliferation, and migration of keratinocytes. Mutations in IRF6 cause two autosomal dominant disorders characterized by cleft lip with or without cl…