Baolin Li
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View article: A Bacterial Platform for Studying Ubiquitination Cascades Anchored by SCF-Type E3 Ubiquitin Ligases
A Bacterial Platform for Studying Ubiquitination Cascades Anchored by SCF-Type E3 Ubiquitin Ligases Open
Ubiquitination is one of the most important post-translational modifications in eukaryotes. The ubiquitination cascade includes ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). The E3 ligas…
View article: Esterase-Activated Theranostic Prodrug for Dual Organelles-Targeted Imaging and Synergetic Chemo-Photodynamic Cancer Therapy
Esterase-Activated Theranostic Prodrug for Dual Organelles-Targeted Imaging and Synergetic Chemo-Photodynamic Cancer Therapy Open
Activatable prodrugs have received considerable attention in cancer therapy due to their high specificity and reduced side effects. However, the theranostic prodrug with multiple cancerous organelles targeting and combinational therapy is …
View article: Traditional Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatient Cases: A Multi-center Randomized Controlled Trial
Traditional Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatient Cases: A Multi-center Randomized Controlled Trial Open
Background: The treatment and rehabilitation of knee osteoarthritis (KOA) are important. This trial was designed to determine the effects of Traditional Chinese Medicine (TCM) involving triple rehabilitation therapy for KOA on the progress…
View article: Novel 4-arylaminoquinazolines bearing <i>N</i>,<i>N</i>-diethyl(aminoethyl)amino moiety with antitumour activity as EGFR<sup>wt</sup>-TK inhibitor
Novel 4-arylaminoquinazolines bearing <i>N</i>,<i>N</i>-diethyl(aminoethyl)amino moiety with antitumour activity as EGFR<sup>wt</sup>-TK inhibitor Open
Herein, four novel 4-arylaminoquinazoline derivatives with N,N-diethyl(aminoethyl)amino moiety were designed, synthesised and evaluated on biological activities in vitro. All synthesised compounds have inhibitory effects against tumour cel…
View article: Design, Synthesis, and Antitumor Activity of Novel Quinazoline Derivatives
Design, Synthesis, and Antitumor Activity of Novel Quinazoline Derivatives Open
In an attempt to explore a new class of epidermal growth factor receptor (EGFR) inhibitors, novel 4-stilbenylamino quinazoline derivatives were synthesized through a Dimorth rearrangement reaction and characterized via IR, 1H-NMR, 13C-NMR,…
View article: Synthesis and Antitumor Activity of Heterozygous Isatin-Quinazoline Compounds
Synthesis and Antitumor Activity of Heterozygous Isatin-Quinazoline Compounds Open
摘要 合成了 9 种靛红杂合的喹唑啉类目标化合物, 借助 NMR、IR 和 HRMS 对目标化合物进行了结构表征,并通过晶 体的培养及 X 射线衍射数据进一步确定了目标化合物的结构
View article: miR‐548d‐3p/<scp>TP</scp>53<scp>BP</scp>2 axis regulates the proliferation and apoptosis of breast cancer cells
miR‐548d‐3p/<span>TP</span>53<span>BP</span>2 axis regulates the proliferation and apoptosis of breast cancer cells Open
Fast growth and hardly any apoptosis are important characteristics of breast cancer, which assure the spread via invasion and metastasis of breast cancer cells. Inhibition of fast proliferation and induction of apoptosis are critical way t…
View article: Synthesis and <i>in Vitro</i> Antiproliferative Evaluation of Novel Hybrids from 1,3,4-Thiadiazole and Benzisoselenazolone
Synthesis and <i>in Vitro</i> Antiproliferative Evaluation of Novel Hybrids from 1,3,4-Thiadiazole and Benzisoselenazolone Open
Novel hybrids from 1,3,4-thiadiazole and benzisoselenazolone were designed, synthesized and evaluated for their in vitro antiproliferative activities by CCK-8 assay against three types of human cancer cell lines, SMMC-7721, MCF-7 and A549 …
View article: Synthesis and Antitumor Activities of Disulfide Derivatives Containing 1,3,4-Thiadiazole Moiety
Synthesis and Antitumor Activities of Disulfide Derivatives Containing 1,3,4-Thiadiazole Moiety Open
含 1,3,4-噻二唑的二硫醚衍生物的合成及抗肿瘤活性研究 李 莎 荆 芬 付小云 赵继军 王雪峰 李宝林 刘玉明 陈宝泉 * (天津理工大学化学化工学院 天津 300384) 摘要 以硫醇、硫脲、2-氨基-5-巯基-1,3,4-噻二唑等为原料, 通过两步反应合成了 10 个新的含 1,3,4-噻二唑的二硫醚 衍生物, 并利用 IR, 1 H NMR, ESI-MS 和元素分析对目标化合物进行了结构表征.采用 CCK-8 法测试了目标产物对人 体肝癌细胞 SMMC-7721…