Bao‐Long Li
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View article: The Bidirectional Mechanism of Uric Acid Levels on Alzheimer’s Disease: A Narrative Review
The Bidirectional Mechanism of Uric Acid Levels on Alzheimer’s Disease: A Narrative Review Open
Alzheimer's disease (AD) is a central nervous system disorder marked by the extracellular accumulation of β-amyloid (Aβ) plaques in the cerebral cortex and the intracellular aggregation of hyperphosphorylated tau protein, manifesting as pr…
View article: Targeting CB1R Rewires Ca<sup>2+</sup>-Dependent Mitophagy to Promote Nerve Regeneration
Targeting CB1R Rewires Ca<sup>2+</sup>-Dependent Mitophagy to Promote Nerve Regeneration Open
Background: Ion homeostasis is disrupted following nerve injury, and elevated Ca2+ levels have been reported to induce Schwann cell (SC) death. Notably, clinical interventions such as electrical stimulation enhance Ca2+ influx and facilita…
View article: Innovative Development of Temporary Plugging Tools for Cased Branch Wells in Offshore Oilfields
Innovative Development of Temporary Plugging Tools for Cased Branch Wells in Offshore Oilfields Open
A novel temporary plugging tool has been developed to address the delayed retrieval of fracturing isolation systems during the completion of casing branch wells in offshore oilfields, where compromised pressure sustainability leads to prol…
View article: Chinese soy-based microbiome and associated microbial risks: a metagenomic investigation
Chinese soy-based microbiome and associated microbial risks: a metagenomic investigation Open
Fermented foods are a longstanding part of the Chinese diet and have been recognized for promoting gut microbial diversity. However, their microbial composition remains poorly defined, raising concerns about potential exposure to pathogens…
View article: Acute and subacute toxicity evaluation of ZhenzhuXiaoji decoction in preclinical models: implications for safe clinical use
Acute and subacute toxicity evaluation of ZhenzhuXiaoji decoction in preclinical models: implications for safe clinical use Open
Background ZhenzhuXiaoji Decoction (ZZXJD) is a traditional Chinese medicine formulation composed of five herbs: Ligustrum lucidum , Curcuma zedoaria , Prunella vulgaris , Hedyotis diffusa , and Glycyrrhiza uralensis , developed for the tr…
View article: Maladaptive Peripheral Ketogenesis in Schwann Cells Mediated by CB<sub>1</sub>R Contributes to Diabetic Neuropathy
Maladaptive Peripheral Ketogenesis in Schwann Cells Mediated by CB<sub>1</sub>R Contributes to Diabetic Neuropathy Open
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes. Although studies have previously investigated metabolic disruptions in the peripheral nervous system (PNS), the exact metabolic mechanisms underlying DPN rem…
View article: Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway
Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway Open
Neuropathic pain poses a significant clinical challenge, largely due to the incomplete understanding of its molecular mechanisms, particularly the role of mitochondrial dysfunction. Bioinformatics analysis revealed that pyroptosis and infl…
View article: Optimal response population after neoadjuvant therapy for patients with locally advanced gastric cancer: A multicenter study
Optimal response population after neoadjuvant therapy for patients with locally advanced gastric cancer: A multicenter study Open
This study reevaluates patients with ORP following NAT, providing a more comprehensive and accurate depiction of the potential beneficiary group and survival outcomes in patients with locally advanced GC.
View article: Syntheses, Structures, and Photocatalytic and Sonocatalytic Degradations of Methyl Blue of Cu(II) and Mn(II) Coordination Polymers Based on Tri(triazole) and Dicarboxylate Ligands
Syntheses, Structures, and Photocatalytic and Sonocatalytic Degradations of Methyl Blue of Cu(II) and Mn(II) Coordination Polymers Based on Tri(triazole) and Dicarboxylate Ligands Open
Cu(II) and Mn(II) coordination polymers [Cu(ttpa)(sub)]n (Cuttpa or 1) and {[Mn2(ttpa)2(nip)2(H2O)2]·3H2O}n (Mnttpa or 2) (ttpa = tris(4-(1,2,4-triazol-1-yl)phenyl)amine, H2sub = suberic acid, nip = 5-nitroisophthalicate) were hydrothermal…
View article: Mechanism of Treadmill Exercise Combined with Rich Environmental Stimulation to Improve Depression in Post-stroke Depression Model Rats
Mechanism of Treadmill Exercise Combined with Rich Environmental Stimulation to Improve Depression in Post-stroke Depression Model Rats Open
Background: Post-stroke depression (PSD) is a common complication, occurring in approximately one-third of these patients. The neurological symptoms of PSD affect patients' daily life and subsequent recovery. Analyzing the pathogenesis of …
View article: Exploring the Microbiome of Fermented Soy Products: Implications for Gut Health in China
Exploring the Microbiome of Fermented Soy Products: Implications for Gut Health in China Open
Background:Fermented foods have a long history in China, and they continue to be widely consumed today. Fermented foods have recently been reported as a pivotal approach to restoring gut microbial diversity and are recommended by the Inter…
View article: Rhizospheric microbiota of suppressive soil protect plants against <scp><i>Fusarium solani</i></scp> infection
Rhizospheric microbiota of suppressive soil protect plants against <span><i>Fusarium solani</i></span> infection Open
BACKGROUND Fusarium infection has caused huge economic losses in many crops. The study aimed to compare the microbial community of suppressive and conducive soils and relate to the reduction of Fusarium wilt. RESULTS High‐throughput sequen…
View article: A tolerance study of maltitol in Chinese healthy subjects: a multicenter, simple-blind, placebo-controlled study
A tolerance study of maltitol in Chinese healthy subjects: a multicenter, simple-blind, placebo-controlled study Open
Objectives: Our aim was to evaluate the gastrointestinal tolerance of maltitol in Chinese individuals, and to explore the gastrointestinal reactions, and small intestine bacterial overgrowth (SIBO). Methods: 132 healthy subjects from three…
View article: Curcumin Improves Functional Recovery of Ruptured Tendon by Promoting Tenogenesis via PI3K/Akt Signaling
Curcumin Improves Functional Recovery of Ruptured Tendon by Promoting Tenogenesis via PI3K/Akt Signaling Open
Objective In our previous study, we found that local release of curcumin from nanomicelles prevents peritendinous adhesion during Achilles tendon healing. The aim of this study is to further investigate the signaling integrated by curcumin…
View article: Effects of health qigong exercise on upper extremity muscle activity, balance function, and quality of life in stroke patients
Effects of health qigong exercise on upper extremity muscle activity, balance function, and quality of life in stroke patients Open
Introduction This study explored the effects of Qigong exercises on upper extremity muscle activity, balance function, and quality of life in stroke patients. Methods A total of 30 stroke patients were randomly allocated to either control …
View article: Sinomenine promotes flap survival by upregulating eNOS and eNOS-mediated autophagy via PI3K/AKT pathway
Sinomenine promotes flap survival by upregulating eNOS and eNOS-mediated autophagy via PI3K/AKT pathway Open
Large skin defects and surgical tissue reconstructions are frequently covered utilizing random flaps. The flap has the advantage of being designed according to the size and shape of a surgical wound. However, the necrosis of the distal par…
View article: Fibroblast Growth Factor 9 Inhibited Apoptosis in Random Flap via the ERK1/2–Nrf2 Pathway to Improve Tissue Survival
Fibroblast Growth Factor 9 Inhibited Apoptosis in Random Flap via the ERK1/2–Nrf2 Pathway to Improve Tissue Survival Open
Background: The application of random pattern skin flaps is limited in plastic surgery reconstruction due to necrosis. Fibroblast growth factor 9 (FGF9) was reported to exert a protective effect against myocardial damage and cerebral ische…
View article: The Endophytic Root Microbiome Is Different in Healthy and Ralstonia solanacearum-Infected Plants and Is Regulated by a Consortium Containing Beneficial Endophytic Bacteria
The Endophytic Root Microbiome Is Different in Healthy and Ralstonia solanacearum-Infected Plants and Is Regulated by a Consortium Containing Beneficial Endophytic Bacteria Open
Bacterial wilt disease causes heavy yield losses in many crops. Endophytic microbiomes play important roles in control of plant diseases.
View article: Microbial network and composition changes according to tobacco varieties and interferes differently in black shank disease defense
Microbial network and composition changes according to tobacco varieties and interferes differently in black shank disease defense Open
Aims The soil-borne oomycete pathogen Phytophthora parasitica can cause black shank disease in tobacco plants. The use of resistant varieties can be used to control black shank disease. The potential relationships of the composition of the…
View article: Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival
Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival Open
The random-pattern skin flap is a crucial technique in reconstructive surgery and flap necrosis caused by ischemia/reperfusion injury is a major postoperative complication. Herein, we investigated the mechanism of mitophagy induced by Mela…