Baoming Liu
YOU?
Author Swipe
View article: Highly stable Cas9 promotes HBV genome destruction by antagonizing HSC70-mediated degradation
Highly stable Cas9 promotes HBV genome destruction by antagonizing HSC70-mediated degradation Open
As a naturally existing adaptive immune system of prokaryotes against phages and foreign genetic materials, the CRISPR/Cas9 system has been widely used to combat various viral infections. However, its ability to destroy the constantly repl…
View article: An urgent need for diagnostic tools to address global mpox public health emergencies
An urgent need for diagnostic tools to address global mpox public health emergencies Open
Monkeypox virus (MPXV) is the causative agent of mpox, a zoonosis formerly known as monkeypox. MPXV can be divided into clades I and II, which are further divided into subclades Ia, Ib, IIa, and IIb. Since May 2022, subclade IIb MPXV has r…
View article: Epidemiology, Clinical Significance, and Diagnosis of Respiratory Viruses and Their Co-Infections in the Post-COVID Era
Epidemiology, Clinical Significance, and Diagnosis of Respiratory Viruses and Their Co-Infections in the Post-COVID Era Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel human coronavirus, emerged in late 2019 and rapidly evolved into a pandemic around the world. The coronavirus disease (COVID-19) pandemic has dramatically changed the ep…
View article: Identification and characterization of an invasive, hyper-aerotolerant <i>Campylobacter jejuni</i> strain causing bacteremia in a pediatric leukemia patient
Identification and characterization of an invasive, hyper-aerotolerant <i>Campylobacter jejuni</i> strain causing bacteremia in a pediatric leukemia patient Open
Background Campylobacter jejuni is a leading pathogen causing gastroenteritis in humans. Invasive C. jejuni strains crossing the gut-blood barrier can cause bacteremia. Despite its microaerophilicity (preferring <5% O 2 atmosphere), hyper-…
View article: Impact of Point-of-Care Testing on Diagnosis, Treatment, and Surveillance of Vaccine-Preventable Viral Infections
Impact of Point-of-Care Testing on Diagnosis, Treatment, and Surveillance of Vaccine-Preventable Viral Infections Open
With the advent of a variety of vaccines against viral infections, there are multiple viruses that can be prevented via vaccination. However, breakthrough infections or uncovered strains can still cause vaccine-preventable viral infections…
View article: Genetic Conservation and Diversity of SARS‐CoV‐2 Envelope Gene Across Variants of Concern
Genetic Conservation and Diversity of SARS‐CoV‐2 Envelope Gene Across Variants of Concern Open
SARS‐CoV‐2 Envelope (E) protein is critical in viral assembly, release, and virulence. E gene was considered highly conserved and evolving slowly. Pan‐sarbecoviruses–conserved regions in the E gene have been used as targets for various RT‐…
View article: Epidemiology, Clinical Significance and Diagnosis of Respiratory Viruses and Their Co-Infections in the Post-COVID Era
Epidemiology, Clinical Significance and Diagnosis of Respiratory Viruses and Their Co-Infections in the Post-COVID Era Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel human coronavirus, emerged in late 2019 and rapidly evolved into a pandemic around the world. The COVID-19 pandemic has dramatically changed the epidemiology and seasona…
View article: Impact of Point-of-Care Testing on Diagnosis, Treatment and Surveillance of Vaccine-Preventable Viral Infections
Impact of Point-of-Care Testing on Diagnosis, Treatment and Surveillance of Vaccine-Preventable Viral Infections Open
With the advent of a variety of vaccines against viral infections, there are multiple viruses that can be prevented via vaccination. However, breakthrough infection or uncovered strains can still cause vaccine-preventable viral infections …
View article: Mechanisms and Assessment of Genotoxicity of Metallic Engineered Nanomaterials in the Human Environment
Mechanisms and Assessment of Genotoxicity of Metallic Engineered Nanomaterials in the Human Environment Open
Engineered nanomaterials (ENMs) have a broad array of applications in agriculture, engineering, manufacturing, and medicine. Decades of toxicology research have demonstrated that ENMs can cause genotoxic effects on bacteria, mammalian cell…
View article: Mpox (Monkeypox) Virus and Its Co-Infection with HIV, Sexually Transmitted Infections, or Bacterial Superinfections: Double Whammy or a New Prime Culprit?
Mpox (Monkeypox) Virus and Its Co-Infection with HIV, Sexually Transmitted Infections, or Bacterial Superinfections: Double Whammy or a New Prime Culprit? Open
Epidemiologic studies have established that mpox (formerly known as monkeypox) outbreaks worldwide in 2022–2023, due to Clade IIb mpox virus (MPXV), disproportionately affected gay, bisexual, and other men who have sex with men. More than …
View article: 606. Clinical Utility of Fungal Blood Cultures for the Diagnosis of Candidemia
606. Clinical Utility of Fungal Blood Cultures for the Diagnosis of Candidemia Open
Background Candidemia is the most common invasive fungal infection in hospitalized children, and the third most common cause of pediatric nosocomial bloodstream infections. The gold standard for diagnosis of Candida bloodstream infections …
View article: The Brief Case: Ventilator-Associated Corynebacterium accolens Pneumonia in a Patient with Respiratory Failure Due to COVID-19
The Brief Case: Ventilator-Associated Corynebacterium accolens Pneumonia in a Patient with Respiratory Failure Due to COVID-19 Open
A 59-year-old man with hypothyroidism and obesity was transferred from an outside hospital to our medical intensive care unit for management of acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19). One day prior t…
View article: The Brief Case: Capnocytophaga sputigena Bacteremia in a 94-Year-Old Male with Type 2 Diabetes Mellitus, Pancytopenia, and Bronchopneumonia
The Brief Case: Capnocytophaga sputigena Bacteremia in a 94-Year-Old Male with Type 2 Diabetes Mellitus, Pancytopenia, and Bronchopneumonia Open
A 94-year-old male presented to the emergency department with 3 days of fever and total body weakness. The patient’s past medical history was significant for coronary artery disease, type 2 diabetes mellitus, gastroesophageal reflux diseas…
View article: Role of Host Immune and Inflammatory Responses in COVID-19 Cases with Underlying Primary Immunodeficiency: A Review
Role of Host Immune and Inflammatory Responses in COVID-19 Cases with Underlying Primary Immunodeficiency: A Review Open
Coronavirus disease 2019 (COVID-19) has spread rapidly and become a pandemic. Caused by a novel human coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), severe COVID-19 is characterized by cytokine storm syndr…
View article: Influenza A virus directly modulates mouse eosinophil responses
Influenza A virus directly modulates mouse eosinophil responses Open
Allergic asthma and influenza are common respiratory diseases with a high probability of co-occurrence. During the 2009 influenza pandemic, hospitalized patients with influenza experienced lower morbidity if asthma was an underlying condit…
View article: Identification of Poxvirus Genome Uncoating and DNA Replication Factors with Mutually Redundant Roles
Identification of Poxvirus Genome Uncoating and DNA Replication Factors with Mutually Redundant Roles Open
Genome uncoating is essential for replication of most viruses. For poxviruses, the process is divided into two stages: removal of the envelope, allowing early gene expression, and breaching of the core wall, allowing DNA release, replicati…
View article: Characterization of Novel Hepatitis B Virus B/C Intergenotypic Recombinants in 3′-terminal Reverse Transcriptase Sequences among Chronic Hepatitis B Patients
Characterization of Novel Hepatitis B Virus B/C Intergenotypic Recombinants in 3′-terminal Reverse Transcriptase Sequences among Chronic Hepatitis B Patients Open
Chronic hepatitis B (CHB) remains a severe global public health concern. Hepatitis B virus (HBV) can be divided into 8 genotypes with different geographical distribution and virological features. We demonstrated genotypes B and C prevalent…
View article: The Molecular Chaperone GRP78 Contributes to Toll-like Receptor 3-mediated Innate Immune Response to Hepatitis C Virus in Hepatocytes
The Molecular Chaperone GRP78 Contributes to Toll-like Receptor 3-mediated Innate Immune Response to Hepatitis C Virus in Hepatocytes Open
Toll-like receptor-3 (TLR3) senses double-stranded RNA intermediates produced during hepatitis C virus (HCV) replication, leading to activation of interferon regulatory factor-3 (IRF3) and NF-κB and subsequent antiviral and proinflammatory…
View article: Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity
Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity Open
The tripartite motif-containing (TRIM) proteins have emerged as a new class of host antiviral restriction factors, with several demonstrating roles in regulating innate antiviral responses.Of >70 known TRIMs, TRIM56 inhibits replication of…
View article: The C-Terminal Tail of TRIM56 Dictates Antiviral Restriction of Influenza A and B Viruses by Impeding Viral RNA Synthesis
The C-Terminal Tail of TRIM56 Dictates Antiviral Restriction of Influenza A and B Viruses by Impeding Viral RNA Synthesis Open
Accumulating data suggest that tripartite-motif-containing (TRIM) proteins participate in host responses to viral infections, either by acting as direct antiviral restriction factors or through regulating innate immune signaling of the hos…