Baorong Zhang
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View article: Association Between Turn Impairments and Cognitive Function in Parkinson Disease
Association Between Turn Impairments and Cognitive Function in Parkinson Disease Open
Objective To investigate the association of turn parameters with cognitive status in patients with Parkinson disease (PD) and determine the value of turn performance in distinguishing PD‐related cognitive impairment (CI) from normal cognit…
View article: Glymphatic dysfunction is related to motor disability fully mediated by gray matter degeneration in early-stage Parkinson's disease
Glymphatic dysfunction is related to motor disability fully mediated by gray matter degeneration in early-stage Parkinson's disease Open
Glymphatic dysfunction in early-stage PD correlates with GM degeneration and motor decline. Left posterior cingulate degeneration fully mediates the impact of glymphatic dysfunction on motor disability. These findings deepen the understand…
View article: A novel c.116 - 117 del variant in Unverricht-Lundborg disease: first ULD report in large Chinese population and review of the pathogenetic variants in CSTB gene
A novel c.116 - 117 del variant in Unverricht-Lundborg disease: first ULD report in large Chinese population and review of the pathogenetic variants in CSTB gene Open
View article: Chronic Pain and Parkinson's Disease: Causation or Confounding?
Chronic Pain and Parkinson's Disease: Causation or Confounding? Open
View article: Association of free-water imaging data for the cholinergic nucleus with the motor function and subtypes in Parkinson’s disease
Association of free-water imaging data for the cholinergic nucleus with the motor function and subtypes in Parkinson’s disease Open
Background Despite the importance of clinical heterogeneity in Parkinson’s disease (PD), its underlying pathophysiology remains unclear. Objective This study aimed to distinguish the association of free-water (FW) imaging data for the chol…
View article: Exploring the active ingredients and potential mechanisms of Pingchan granules in Parkinson’s disease treatment through network pharmacology and transcriptomics
Exploring the active ingredients and potential mechanisms of Pingchan granules in Parkinson’s disease treatment through network pharmacology and transcriptomics Open
View article: Gradients of Nigrostriatal Iron Deposition in Healthy Aging and Synucleinopathies
Gradients of Nigrostriatal Iron Deposition in Healthy Aging and Synucleinopathies Open
Aims To investigate the gradients of nigrostriatal iron deposition in aging, Parkinson's disease (PD), and multiple system atrophy (MSA). Methods This study included 100 young healthy controls, 171 old healthy controls (OHC), 231 PD, and 2…
View article: Aberrant functional connectome gradient and its neurotransmitter basis in Parkinson's disease
Aberrant functional connectome gradient and its neurotransmitter basis in Parkinson's disease Open
Patients with Parkinson's disease (PD) exhibit heterogenous clinical deficits not only in motor function, other deficits in both sensory and higher-order cognitive processing are also involved. Connectome studies have suggested a primary-t…
View article: The effect of occlusal balance and prosthesis on occlusal function of patients after dental implant restoration
The effect of occlusal balance and prosthesis on occlusal function of patients after dental implant restoration Open
View article: Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study
Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study Open
Traffic-related air pollution (TRAP) has been linked with numerous respiratory diseases. Recently, lung microbiome is proposed to be characterized with development and progression of respiratory diseases. However, the underlying effects of…
View article: Locus Coeruleus Degeneration in Essential Tremor With Mild Cognitive Impairment: A Neuromelanin <scp>MRI</scp> Study
Locus Coeruleus Degeneration in Essential Tremor With Mild Cognitive Impairment: A Neuromelanin <span>MRI</span> Study Open
Objective Our aim was to research the neuromelanin‐sensitive magnetic resonance imaging (NM‐MRI) features of the locus coeruleus (LC) in essential tremor (ET) patients of various cognitive states and to explore the relationships between th…
View article: Spatiotemporal neurodegeneration of the substantia nigra and its connecting cortex and subcortex in Parkinson's disease
Spatiotemporal neurodegeneration of the substantia nigra and its connecting cortex and subcortex in Parkinson's disease Open
Background and purpose Neurodegeneration is uneven in Parkinson's disease (PD). This study aimed to investigate spatiotemporal neurodegeneration in functional subregions of the substantia nigra (SN) and their connected cortex and subcortex…
View article: No causal relationship between ankylosing spondylitis and Parkinson's disease: Insights from Mendelian randomization studies
No causal relationship between ankylosing spondylitis and Parkinson's disease: Insights from Mendelian randomization studies Open
In contrast to numerous existing clinical studies, this study failed to provide evidence supporting a significant impact of AS on PD risk, or vice versa. Further investigations regarding the potential causal mechanisms linking AS and PD ar…
View article: Contrastive machine learning reveals Parkinson’s disease specific features associated with disease severity and progression
Contrastive machine learning reveals Parkinson’s disease specific features associated with disease severity and progression Open
View article: NOX4 exacerbates Parkinson’s disease pathology by promoting neuronal ferroptosis and neuroinflammation
NOX4 exacerbates Parkinson’s disease pathology by promoting neuronal ferroptosis and neuroinflammation Open
JOURNAL/nrgr/04.03/01300535-202507000-00026/figure1/v/2024-09-09T124005Z/r/image-tiff Parkinson’s disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra compacta. Ferroptosis, a novel form of regulated cell…
View article: Assessing the Role of Locus Coeruleus Degeneration in Essential Tremor and Parkinson’s Disease with Sleep Disorders
Assessing the Role of Locus Coeruleus Degeneration in Essential Tremor and Parkinson’s Disease with Sleep Disorders Open
Background: Previous studies have demonstrated the importance of the locus coeruleus (LC) in sleep-wake regulation. Both essential tremor (ET) and Parkinson’s disease (PD) share common sleep disorders, such as poor quality of sleep (QoS). …
View article: The longitudinal volumetric and shape changes of subcortical nuclei in Parkinson’s disease
The longitudinal volumetric and shape changes of subcortical nuclei in Parkinson’s disease Open
View article: Microstructural degeneration of the corpus callosum in Parkinson’s disease with unilateral onset: A free-water imaging study
Microstructural degeneration of the corpus callosum in Parkinson’s disease with unilateral onset: A free-water imaging study Open
Background The laterality of motor symptoms is an important clinical feature of PD, which is not only manifested as the lateral dysfunctions of limbs but also affects the non-motor symptoms and the prognosis in PD patients. Former studies …
View article: Microstructural alterations of the hypothalamus in Parkinson's disease and probable REM sleep behavior disorder
Microstructural alterations of the hypothalamus in Parkinson's disease and probable REM sleep behavior disorder Open
Our study reveals that microstructural changes in the hypothalamus are already significant at the early neurodegenerative stage. These changes are associated with emotional alterations, daily activity levels, and thyroid hormone levels.
View article: Safety of teriflunomide in Chinese adult patients with relapsing multiple sclerosis: A phase IV, 24-week multicenter study
Safety of teriflunomide in Chinese adult patients with relapsing multiple sclerosis: A phase IV, 24-week multicenter study Open
Background: Disease-modifying therapies have been approved for the treatment of relapsing multiple sclerosis (RMS). The present study aims to examine the safety of teriflunomide in Chinese patients with RMS. Methods: This non-randomized, m…
View article: Author Correction: Two distinct trajectories of clinical and neurodegeneration events in Parkinson’s disease
Author Correction: Two distinct trajectories of clinical and neurodegeneration events in Parkinson’s disease Open
View article: Neurovascular coupling alteration in drug-naïve Parkinson's disease: The underlying molecular mechanisms and levodopa's restoration effects
Neurovascular coupling alteration in drug-naïve Parkinson's disease: The underlying molecular mechanisms and levodopa's restoration effects Open
Patients exhibited NVC dysfunction primarily in the striato-thalamo-cortical circuit and motor control regions, which could be driven by dopaminergic and nondopaminergic systems, and levodopa therapy mainly restored abnormal NVC by modulat…
View article: Alteration of functional connectivity network in population of objectively-defined subtle cognitive decline
Alteration of functional connectivity network in population of objectively-defined subtle cognitive decline Open
The objectively-defined subtle cognitive decline individuals had higher progression rates of cognitive decline and pathological deposition than healthy elderly, indicating a higher risk of progressing to Alzheimer’s disease. However, littl…
View article: The longitudinal volumetric and shape changes of subcortical nuclei in Parkinson’s disease
The longitudinal volumetric and shape changes of subcortical nuclei in Parkinson’s disease Open
Objective Brain structural changes in Parkinson's disease (PD) are progressive throughout the disease course. Changes in surface morphology with disease progression remain unclear. This study aimed to assess the volumetric and shape change…
View article: The effect of dopamine replacement therapy on cortical structure in Parkinson's disease
The effect of dopamine replacement therapy on cortical structure in Parkinson's disease Open
Aims To explore the cortical structural reorganization in Parkinson's disease (PD) patients under chronic dopamine replacement therapy (DRT) in cross‐sectional and longitudinal data and determine whether these changes were associated with …
View article: Fibroblast growth factor-21 alleviates proteasome injury via activation of autophagy flux in Parkinson’s disease
Fibroblast growth factor-21 alleviates proteasome injury via activation of autophagy flux in Parkinson’s disease Open
View article: Cholinergic basal forebrain system degeneration underlies postural instability/gait difficulty and attention impairment in Parkinson's disease
Cholinergic basal forebrain system degeneration underlies postural instability/gait difficulty and attention impairment in Parkinson's disease Open
Background and purpose The specific pathophysiological mechanisms underlying postural instability/gait difficulty (PIGD) and cognitive function in Parkinson's disease (PD) remain unclear. Both postural and gait control, as well as cognitiv…
View article: Analysis of common genetic variation of anxiety disorders in essential tremor
Analysis of common genetic variation of anxiety disorders in essential tremor Open
Objective To explore the association of common genetic variation of anxiety disorders and essential tremor (ET). Methods We genotyped 25 anxiety-specific risk variants in a cohort of 478 unrelated ET patients and 505 age and gender-matched…
View article: Establishing an online resource to facilitate global collaboration and inclusion of underrepresented populations: Experience from the MJFF Global Genetic Parkinson’s Disease Project
Establishing an online resource to facilitate global collaboration and inclusion of underrepresented populations: Experience from the MJFF Global Genetic Parkinson’s Disease Project Open
Parkinson’s disease (PD) is the fastest-growing neurodegenerative disorder, currently affecting ~7 million people worldwide. PD is clinically and genetically heterogeneous, with at least 10% of all cases explained by a monogenic cause or s…
View article: Evaluation of Nocturnal Symptoms in Chinese Parkinson’s Disease Patients Based on the PDSS-2 Scale: A Multicenter Cross-Sectional Study
Evaluation of Nocturnal Symptoms in Chinese Parkinson’s Disease Patients Based on the PDSS-2 Scale: A Multicenter Cross-Sectional Study Open
Background: Nocturnal symptoms have a significant effect on the quality of life in Parkinson’s disease (PD) patients. Objective: This study aimed to investigate the prevalence and associated factors of nocturnal symptoms in Chinese PD pati…