Baoshan Cai
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View article: Usp18–Hrd1 Erad Signaling Pathway Inhibits Nlrp3 Inflammasome Activation and Decelerates the Aging Process
Usp18–Hrd1 Erad Signaling Pathway Inhibits Nlrp3 Inflammasome Activation and Decelerates the Aging Process Open
View article: Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response
Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response Open
The enzyme cyclic GMP-AMP synthase (cGAS) is a key sensor for detecting misplaced double-stranded DNA (dsDNA) of genomic, mitochondrial, and microbial origin. It synthesizes 2′3′-cGAMP, which in turn activates the stimulator of interferon …
View article: LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway
LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway Open
The excessive activation of immune responses will trigger autoimmune diseases or inflammatory injury. The endosomal sorting complexes required for transport (ESCRT) system can capture and mediate ubiquitinated protein degradation, which ti…
View article: LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway
LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway Open
The excessive activation of immune responses will trigger autoimmune diseases or inflammatory injury. The endosomal sorting complexes required for transport (ESCRT) system can capture and mediate ubiquitinated protein degradation, which ti…
View article: USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3
USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3 Open
3-MA: 3-methyladenine; AIM2: absent in melanoma 2; ATG5: autophagy related 5; BafA1: bafilomycin A1; CASP1: caspase 1; CHX: cycloheximide; Co-IP: co-immunoprecipitation; CQ: chloroquine; DUBs: deubiquitinases; IL1B/IL-1β: interl…
View article: Methyltransferase‐Like Protein 14 Attenuates Mitochondrial Antiviral Signaling Protein Expression to Negatively Regulate Antiviral Immunity via N<sup>6</sup>‐methyladenosine Modification
Methyltransferase‐Like Protein 14 Attenuates Mitochondrial Antiviral Signaling Protein Expression to Negatively Regulate Antiviral Immunity via N<sup>6</sup>‐methyladenosine Modification Open
Mitochondrial antiviral signaling (MAVS) protein is the core signaling adaptor in the RNA signaling pathway. Thus, appropriate regulation of MAVS expression is essential for antiviral immunity against RNA virus infection. However, the regu…
View article: TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1
TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1 Open
View article: USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3
USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3 Open
The NLRP3 (NLR family pyrin domain containing 3) inflammasome is involved in diverse inflammatory diseases, thus strict control of its activation is necessary to prevent excessive inflammation. Protein ubiquitination has been reported to r…
View article: USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3
USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3 Open
The NLRP3 (NLR family pyrin domain containing 3) inflammasome is involved in diverse inflammatory diseases, thus strict control of its activation is necessary to prevent excessive inflammation. Protein ubiquitination has been reported to r…
View article: USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3
USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3 Open
The NLRP3 (NLR family pyrin domain containing 3) inflammasome is involved in diverse inflammatory diseases, thus strict control of its activation is necessary to prevent excessive inflammation. Protein ubiquitination has been reported to r…
View article: OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING
OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING Open
View article: Regulation of innate antiviral immunity by protein ubiquitination
Regulation of innate antiviral immunity by protein ubiquitination Open
recognition receptors, PRRs)识别病原微生物上相对保守的相关分子模式(pathogen-associated molecular patterns, PAMPs).病毒相关的核酸成分可以被机体Toll样受体(Toll-like receptors, TLRs)