Bao‐Zhong Wang
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View article: Differential Effects of Biogas Slurry Topdressing on Winter Wheat (Triticum aestivum L.) Soil Enzyme–Microbe Interactions
Differential Effects of Biogas Slurry Topdressing on Winter Wheat (Triticum aestivum L.) Soil Enzyme–Microbe Interactions Open
This study explored how top-dressed biogas slurry at winter wheat’s (Triticum aestivum L.) jointing stage (JS) and grain-filling period (GP) affects soil enzyme–microbe interactions, aiming to address nutrient supply–crop demand mismatches…
View article: Comprehensive Evaluation of Biogas Slurry Fertility: A Study Based on the Effects of Biogas Slurry Irrigation on Soil Microorganisms and Enzyme Activities in Winter Wheat Fields
Comprehensive Evaluation of Biogas Slurry Fertility: A Study Based on the Effects of Biogas Slurry Irrigation on Soil Microorganisms and Enzyme Activities in Winter Wheat Fields Open
This study evaluates the impact of using biogas slurry (BS) instead of nitrogen fertilizer (NF) on wheat soil, and aims to provide an optimized fertilization strategy for green wheat production. Five fertilization modes were tested: basal …
View article: Experimental study on cooling system for new energy engineering vehicles
Experimental study on cooling system for new energy engineering vehicles Open
In order to study in depth the changing patterns of cooling performance of the cooling system for new energy engineering vehicles, a test bed integrating the air conditioning system and the coolant circuit was established. Subsequent tests…
View article: Biomimetic design and experimental study of marine riser fairings for vortex-induced vibration suppression
Biomimetic design and experimental study of marine riser fairings for vortex-induced vibration suppression Open
With the shift of oil and gas exploration to offshore environments, suppressing vortex-induced vibration (VIV) in riser systems—critical for drilling and fluid transport on floating platforms—has become imperative. Experimental studies on …
View article: Mature Dendritic Cell-Derived Extracellular Vesicles are Potent Mucosal Adjuvants for Influenza Hemagglutinin Vaccines
Mature Dendritic Cell-Derived Extracellular Vesicles are Potent Mucosal Adjuvants for Influenza Hemagglutinin Vaccines Open
Immune cell-derived extracellular vesicles (EVs) possess intrinsic immunomodulatory properties, making them potential vaccine adjuvants. Here, we show that EVs from mature bone marrow-derived dendritic cells (mDC-EVs), rather than those fr…
View article: Intranasal vaccination with multi-neuraminidase and M2e virus-like particle vaccine results in greater mucosal immunity and protection against influenza than intramuscular injection
Intranasal vaccination with multi-neuraminidase and M2e virus-like particle vaccine results in greater mucosal immunity and protection against influenza than intramuscular injection Open
Intramuscular injection of seasonal influenza vaccines provides strain-specific neutralizing antibodies, but not against variants, and no effective mucosal immunity. Here, we report that multi-subtype neuraminidase (NA) and M2 ectodomain r…
View article: Dual roles of influenza B virus neuraminidase mRNA vaccine in enhancing cross-lineage protection by supplementing inactivated split vaccination
Dual roles of influenza B virus neuraminidase mRNA vaccine in enhancing cross-lineage protection by supplementing inactivated split vaccination Open
The current influenza vaccine is based on immunity to hemagglutinin (HA) and provides poor cross-protection. Here, we generated mRNA vaccine encoding influenza B virus (IBV) neuraminidase (NA) conjugated to influenza A virus M2 ectodomain …
View article: Carbon and nitrogen stoichiometry across plant–soil system accounts for the degradation of multi-year alfalfa grassland
Carbon and nitrogen stoichiometry across plant–soil system accounts for the degradation of multi-year alfalfa grassland Open
Alfalfa ( Medicago sativa L.) grassland is prone to degradation following multi-year maintenance. Yet, its mechanism regarding the stoichiometry of carbon (C) and nitrogen (N) across plant–soil system is still unclear. To address this issu…
View article: Enhancing cross-protection against influenza by heterologous sequential immunization with mRNA LNP and protein nanoparticle vaccines
Enhancing cross-protection against influenza by heterologous sequential immunization with mRNA LNP and protein nanoparticle vaccines Open
View article: Advancing universal influenza vaccines: insights from cellular immunity targeting the conserved hemagglutinin stalk domain in humans
Advancing universal influenza vaccines: insights from cellular immunity targeting the conserved hemagglutinin stalk domain in humans Open
View article: Single-cell transcriptome analysis profiling lymphatic invasion-related TME in colorectal cancer
Single-cell transcriptome analysis profiling lymphatic invasion-related TME in colorectal cancer Open
Lymphatic invasion (LI) is extremely aggressive and induces worse prognosis among patients with colorectal cancer (CRC). Thus, it is critical to characterize the cellular and molecular mechanisms underlying LI in order to establish novel a…
View article: Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice
Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice Open
View article: Effects of intra-variety root competition and soil fertility on resource allocation in a modern wheat variety and an old landrace
Effects of intra-variety root competition and soil fertility on resource allocation in a modern wheat variety and an old landrace Open
Darwinian agriculture (also called Evolutionary agroecology) which focuses on the trade-off between individual fitness and community performance, can provide an efficient approach to enhance crop production. However, evolutionary or ecolog…
View article: mRNA Vaccine Nanoplatforms and Innate Immunity
mRNA Vaccine Nanoplatforms and Innate Immunity Open
mRNA-based vaccine technology has been significantly developed and enhanced, particularly highlighted by the authorization of mRNA vaccines for addressing the COVID-19 pandemic. Various biomaterials are developed in nano-scales and applied…
View article: Double-layered protein nanoparticles conjugated with truncated flagellin induce improved mucosal and systemic immune responses in mice
Double-layered protein nanoparticles conjugated with truncated flagellin induce improved mucosal and systemic immune responses in mice Open
Intranasal immunization with HA3-tFliC/NP SDAD protein nanoparticles enhances both systemic and mucosal immunity, promoting influenza cross-protection. Sequential priming immunization further enhances GC B cells, Tfh cells, and effector T …
View article: Influenza immune imprinting synergizes PEI-HA/CpG nanoparticle vaccine protection against heterosubtypic infection in mice
Influenza immune imprinting synergizes PEI-HA/CpG nanoparticle vaccine protection against heterosubtypic infection in mice Open
View article: Heterologous Prime-Boost Vaccination with Inactivated Influenza Viruses Induces More Effective Cross-Protection than Homologous Repeat Vaccination
Heterologous Prime-Boost Vaccination with Inactivated Influenza Viruses Induces More Effective Cross-Protection than Homologous Repeat Vaccination Open
With concerns about the efficacy of repeat annual influenza vaccination, it is important to better understand the impact of priming vaccine immunity and develop an effective vaccination strategy. Here, we determined the impact of heterolog…
View article: ISCOMs/MPLA‐Adjuvanted SDAD Protein Nanoparticles Induce Improved Mucosal Immune Responses and Cross‐Protection in Mice
ISCOMs/MPLA‐Adjuvanted SDAD Protein Nanoparticles Induce Improved Mucosal Immune Responses and Cross‐Protection in Mice Open
The epidemics caused by the influenza virus are a serious threat to public health and the economy. Adding appropriate adjuvants to improve immunogenicity and finding effective mucosal vaccines to combat respiratory infection at the portal …
View article: Particulate characteristics of engineered nanoparticle vaccines modulate vaccine immunogenicity in an intranasal route
Particulate characteristics of engineered nanoparticle vaccines modulate vaccine immunogenicity in an intranasal route Open
The intranasal route is an ideal vaccination route for preventing infectious respiratory diseases due to its capability of generating both mucosal immunity—the first line of defense against respiratory virus invasion—and systemic immunity.…
View article: ISCOMs/MPLA adjuvanted SDAD protein nanoparticles induce improved immune responses and cross-protection in mice
ISCOMs/MPLA adjuvanted SDAD protein nanoparticles induce improved immune responses and cross-protection in mice Open
The development of a universal influenza vaccine to protect against influenza variants will be the priority goal in combating influenza virus infection. In this study, we exploited a novel type of protein nanoparticles consisting of influe…
View article: Does a tragedy of the commons due to individual competition arise from genetically fixed traits or plastic traits in dryland wheat? An experimental verification
Does a tragedy of the commons due to individual competition arise from genetically fixed traits or plastic traits in dryland wheat? An experimental verification Open
Growth redundancy, the overgrowth of resource-foraging organs in crop stands, is often detrimental to yield and is thus called a ‘tragedy of the commons’. A tragedy can also arise owing to the plastic overproduction of competitive structur…
View article: Moss-dominated biocrust-based biodiversity enhances carbon sequestration via water interception and plant-soil-microbe interactions
Moss-dominated biocrust-based biodiversity enhances carbon sequestration via water interception and plant-soil-microbe interactions Open
View article: cGAMP-adjuvanted multivalent influenza mRNA vaccines induce broadly protective immunity through cutaneous vaccination in mice
cGAMP-adjuvanted multivalent influenza mRNA vaccines induce broadly protective immunity through cutaneous vaccination in mice Open
View article: Monophosphoryl lipid A-adjuvanted nucleoprotein-neuraminidase nanoparticles improve immune protection against divergent influenza viruses
Monophosphoryl lipid A-adjuvanted nucleoprotein-neuraminidase nanoparticles improve immune protection against divergent influenza viruses Open
View article: Chimeric Virus-like Particles Co-Displaying Hemagglutinin Stem and the C-Terminal Fragment of DnaK Confer Heterologous Influenza Protection in Mice
Chimeric Virus-like Particles Co-Displaying Hemagglutinin Stem and the C-Terminal Fragment of DnaK Confer Heterologous Influenza Protection in Mice Open
Influenza virus hemagglutinin (HA) stem is currently regarded as an extremely promising immunogen for designing universal influenza vaccines. The appropriate antigen-presenting vaccine vector would be conducive to increasing the immunogeni…
View article: Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle
Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle Open
Annual influenza vaccination is recommended to update the variable hemagglutinin antigens. Here, we first designed a virus-like particle (VLP) displaying consensus multi-neuraminidase (NA) subtypes (cN1, cN2, B cNA) and M2 ectodomain (M2e)…
View article: Adjuvant Effects of a New Saponin Analog VSA-1 on Enhancing Homologous and Heterosubtypic Protection by Influenza Virus Vaccination
Adjuvant Effects of a New Saponin Analog VSA-1 on Enhancing Homologous and Heterosubtypic Protection by Influenza Virus Vaccination Open
Adjuvants can increase the magnitude and durability of the immune response generated by the vaccine antigen. Aluminum salts (Alum) remain the main adjuvant licensed for human use. A few new adjuvants have been licensed for use in human vac…
View article: A Review of Studies on National Central Cities: Perspectives and Explorations
A Review of Studies on National Central Cities: Perspectives and Explorations Open
National central cities are important spatial carriers for China's development strategies, and focusing on them main research viewpoints has a certain guiding significance for promoting the high-quality development of national central citi…
View article: Layered protein nanoparticles containing influenza B HA stalk induced sustained cross-protection against viruses spanning both viral lineages
Layered protein nanoparticles containing influenza B HA stalk induced sustained cross-protection against viruses spanning both viral lineages Open
View article: A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine
A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine Open