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View article: Pregnancy and postpartum dynamics revealed by millions of lab tests
Pregnancy and postpartum dynamics revealed by millions of lab tests Open
Pregnancy and delivery involve dynamic alterations in many physiological systems. However, the physiological dynamics during pregnancy and after delivery have not been systematically analyzed at high temporal resolution in a large human po…
View article: Quantification of beta cell carrying capacity in prediabetes
Quantification of beta cell carrying capacity in prediabetes Open
Prediabetes, a subclinical state of high glucose, carries a risk of transition to diabetes. One cause of prediabetes is insulin resistance, which impairs the ability of insulin to control blood glucose. However, many individuals with high …
View article: First-in-human study of the CAPTIS embolic protection system during transcatheter aortic valve replacement
First-in-human study of the CAPTIS embolic protection system during transcatheter aortic valve replacement Open
The use of the CAPTIS full-body embolic protection system during TAVR was safe, and it captured a substantial number of debris particles. No patient suffered from a cerebrovascular event. A randomised clinical trial is warranted to prove i…
View article: Excitable dynamics of flares and relapses in autoimmune diseases
Excitable dynamics of flares and relapses in autoimmune diseases Open
Many autoimmune disorders exhibit flares in which symptoms erupt and then decline, as exemplified by multiple sclerosis (MS) in its relapsing-remitting form. Existing mathematical models of autoimmune flares often assume regular oscillatio…
View article: Unifying design principles of endocrine gland mass and its regulatory circuits
Unifying design principles of endocrine gland mass and its regulatory circuits Open
Hormones are regulatory molecules that impact physiological functions. Much is known about individual hormones, but general rules that connect the regulatory logic of different hormone systems are limited. In this study, we analyzed a rang…
View article: Pregnancy and postpartum dynamics revealed by millions of lab tests
Pregnancy and postpartum dynamics revealed by millions of lab tests Open
Pregnancy and delivery involve dynamic alterations in many physiological systems. However, the physiological dynamics during pregnancy and after delivery have not been systematically analyzed at high temporal resolution in a large human po…
View article: Excitable dynamics of flares and relapses in autoimmune diseases
Excitable dynamics of flares and relapses in autoimmune diseases Open
Many autoimmune diseases show flares in which symptoms erupt and then decline. A prominent example is multiple sclerosis (MS) in its relapsing-remitting phase. Mathematical models attempting to capture the flares in multiple sclerosis have…
View article: Rules for body fat interventions based on an operating point mechanism
Rules for body fat interventions based on an operating point mechanism Open
Interventions to reduce fat are important for human health. However, they can have opposing effects such as exercise that decreases fat but increases food intake, or coherent effects such as leptin resistance which raises both. Furthermore…
View article: Damage dynamics in single<i>E. coli</i>and the role of chance in the timing of cell death
Damage dynamics in single<i>E. coli</i>and the role of chance in the timing of cell death Open
Genetically identical cells in the same stressful condition die at different times. The origin of this stochasticity is unclear; it may arise from different initial conditions that affect the time of demise, or from a stochastic damage acc…
View article: Dynamics of thyroid diseases and thyroid‐axis gland masses
Dynamics of thyroid diseases and thyroid‐axis gland masses Open
Thyroid disorders are common and often require lifelong hormone replacement. Treating thyroid disorders involves a fascinating and troublesome delay, in which it takes many weeks for serum thyroid-stimulating hormone (TSH) concentration to…
View article: Burns During Coronavirus Disease 19 Lockdown: a Multi-Center Retrospective Study in Israel
Burns During Coronavirus Disease 19 Lockdown: a Multi-Center Retrospective Study in Israel Open
The coronavirus disease 2019 (COVID-19) pandemic forced many countries into lockdowns to limit the spread of infection. Israel’s containment measures included school closures, mobility restrictions, and workforce reductions. Our study eval…
View article: Hormone seasonality in medical records suggests circannual endocrine circuits
Hormone seasonality in medical records suggests circannual endocrine circuits Open
Significance We provide a dataset of millions of hormone tests from medical records that shows seasonality with a winter−spring peak in hormones for reproduction, growth, metabolism, and stress adaptation. Together with a long history of s…
View article: Clinical Course and Outcomes of Severe Covid-19: A National Scale Study
Clinical Course and Outcomes of Severe Covid-19: A National Scale Study Open
Knowledge of the outcomes of critically ill patients is crucial for health and government officials who are planning how to address local outbreaks. The factors associated with outcomes of critically ill patients with coronavirus disease 2…
View article: Human hormone seasonality
Human hormone seasonality Open
Hormones control the major biological functions of stress response, growth, metabolism and reproduction. In animals these hormones show pronounced seasonality, with different set-points for different seasons. In humans, the seasonality of …
View article: A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks
A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks Open
Stress activates a complex network of hormones known as the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is dysregulated in chronic stress and psychiatric disorders, but the origin of this dysregulation is unclear and cannot be …