Barani Kumar Rajendran
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View article: High MGMT expression identifies aggressive colorectal cancer with distinct genomic features and immune evasion properties
High MGMT expression identifies aggressive colorectal cancer with distinct genomic features and immune evasion properties Open
Introduction The epigenetic silencing of O 6 -methylguanine DNA methyltransferase ( MGMT ) is associated with reduced DNA repair capacity, carcinogenesis and increased sensitivity to alkylating chemotherapy. However, the biological role an…
View article: Phyto-Fabrication Tribulus terrestris Mediated Iron Oxide Nanoparticles: A Promising Approach of Antioxidant and Anticancer Activities via in vitro and in silico Studies
Phyto-Fabrication Tribulus terrestris Mediated Iron Oxide Nanoparticles: A Promising Approach of Antioxidant and Anticancer Activities via in vitro and in silico Studies Open
Background: Plant-mediated iron nanoparticles are increasingly utilized in biomedical and health applications due to their biocompatibility and nontoxicity. The therapeutic characteristics of these nanoparticles are extensively diverse. Me…
View article: The molecular determinants regulating redox signaling in diabetic endothelial cells
The molecular determinants regulating redox signaling in diabetic endothelial cells Open
Oxidation and reduction are vital for keeping life through several prime mechanisms, including respiration, metabolism, and other energy supplies. Mitochondria are considered the cell’s powerhouse and use nutrients to produce redox potenti…
View article: IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer
IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer Open
View article: Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease
Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease Open
Angiopoietin-like 4 (ANGPTL4), a key protein involved in lipoprotein metabolism, has diverse effects. There is an association between Angptl4 and diabetic kidney disease; however, this association has not been well investigated. We show th…
View article: Advances in predicting breast cancer driver mutations: Tools for precision oncology (Review)
Advances in predicting breast cancer driver mutations: Tools for precision oncology (Review) Open
In the modern era of medicine, prognosis and treatment, options for a number of cancer types including breast cancer have been improved by the identification of cancer‑specific biomarkers. The availability of high‑throughput sequencing and…
View article: Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis
Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis Open
Neutrophils are important innate immune cells with plasticity, heterogenicity, and functional ambivalency. While bone marrow is often regarded as the primary source of neutrophil production, the roles of extramedullary production in regula…
View article: The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells
The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells Open
CD8 + T cells play an important role in anti-tumor immunity. Better understanding of their regulation could advance cancer immunotherapies. Here we identify, via stepwise CRISPR-based screening, that CUL5 is a negative regulator of the cor…
View article: Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease
Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease Open
Angiopoietin-like 4 (ANGPTL4) is the key protein involved in lipoprotein metabolism and has been shown to have diverse effects on tissue protection. In clinical settings, there is a reported association between higher levels of plasma Angp…
View article: 606 IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapy
606 IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapy Open
Background The presence of TLS in tumor tissues is associated with good prognosis and increased immunotherapy sensitivity across several cancers. In an analysis of samples from the Phase II POPLAR trial of atezolizumab vs chemotherapy in p…
View article: Insights of Endocytosis Signaling in Health and Disease
Insights of Endocytosis Signaling in Health and Disease Open
Endocytosis in mammalian cells is a fundamental cellular machinery that regulates vital physiological processes, such as the absorption of metabolites, release of neurotransmitters, uptake of hormone cellular defense, and delivery of biomo…
View article: Loss of WNT5 Proteins Reprograms Neutrophils in the Spleen to Provide Protection for DSS-Induced Colitis
Loss of WNT5 Proteins Reprograms Neutrophils in the Spleen to Provide Protection for DSS-Induced Colitis Open
WNT5A and WNT5B are two close homologs, both of which are implicated in the pathogenesis of inflammatory bowel diseases. However, the roles these two proteins play in the disease remain largely uncharacterized. Here, we report that double …
View article: Lack of Fzd6 in Ciliated Cells Suppresses Ferroptotic Pulmonary Alveolar Cell Death Induced by LPS and Coronavirus
Lack of Fzd6 in Ciliated Cells Suppresses Ferroptotic Pulmonary Alveolar Cell Death Induced by LPS and Coronavirus Open
Pulmonary inflammation compromises lung barrier function and underlies many lung diseases including acute lung injury and acute respiratory distress syndrome (ARDS). However, mechanisms by which lung cells respond to the damage caused by t…
View article: Insights of Endocytosis Signaling in Health and Disease
Insights of Endocytosis Signaling in Health and Disease Open
Endocytosis in mammalian cells is a fundamental cellular machinery that regulates vital physiological processes, such as the absorption of metabolites, release of neurotransmitters, hormonal secretion, cellular defense, and delivery of bio…
View article: The Cul5 E3 Ligase Complex Is a Key Negative Feedback Regulator of TCR/IL2 Signaling and Anti-Tumor Activity in CD8<sup>+</sup>T Cells
The Cul5 E3 Ligase Complex Is a Key Negative Feedback Regulator of TCR/IL2 Signaling and Anti-Tumor Activity in CD8<sup>+</sup>T Cells Open
CD8 + T cells play an important role in tumor immune surveillance and control. Better understanding of the regulation of their anti-tumor actions and improving their cytotoxic function and persistence will help advancing cancer immunothera…
View article: Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations
Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations Open
The incidence of cutaneous T-cell lymphoma (CTCL) increases with age, and blood involvement portends a worse prognosis. To advance our understanding of the development of CTCL and identify potential therapeutic targets, we performed integr…
View article: Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics Open
Nasopharyngeal carcinoma (NPC) is a malignant head and neck cancer type with high morbidity in Southeast Asia, however the pathogenic mechanism of this disease is poorly understood. Using integrative pharmacogenomics, we find that NPC subt…
View article: Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform
Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform Open
The feasibility of personalized medicine for cancer treatment is largely hampered by costly, labor-intensive and time-consuming models for drug discovery. Herein, establishing new pre-clinical models to tackle these issues for personalized…
View article: NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation Open
View article: Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, Bungarus caeruleus
Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, Bungarus caeruleus Open
View article: A comprehensive genomic meta-analysis identifies confirmatory role of<i>OBSCN</i>gene in breast tumorigenesis
A comprehensive genomic meta-analysis identifies confirmatory role of<i>OBSCN</i>gene in breast tumorigenesis Open
The giant multifunctional protein "OBSCURIN" is encoded by OBSCN gene and is mostly expressed in cardiac and other skeletal muscles responsible for myofibrils organization. Loss of OBSCURIN affects the entire downstream pathway prot…
View article: Characterization of potential driver mutations involved in human breast cancer by computational approaches
Characterization of potential driver mutations involved in human breast cancer by computational approaches Open
Breast cancer is the second most frequently occurring form of cancer and is also the second most lethal cancer in women worldwide. A genetic mutation is one of the key factors that alter multiple cellular regulatory pathways and drive brea…