Barbara A. Bensing
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View article: Sialic acid identity modulates host tropism of sialoglycan-binding viridans group streptococci
Sialic acid identity modulates host tropism of sialoglycan-binding viridans group streptococci Open
Microbial interactions with multiple species may expand the range of potential hosts, supporting both pathogen reservoirs and zoonotic spillover. Viridans group streptococci interact with host cells by engaging protein-attached glycosylati…
View article: Sialic Acid Identity Modulates Host Tropism of Sialoglycan-binding Viridans Group Streptococci
Sialic Acid Identity Modulates Host Tropism of Sialoglycan-binding Viridans Group Streptococci Open
Microbial interactions with multiple species may expand the range of potential hosts, supporting both pathogen reservoirs and zoonotic spillover. Viridans group streptococci interact with host cells by engaging protein-attached glycosylati…
View article: HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and resistance to neutralizing antibodies
HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and resistance to neutralizing antibodies Open
Bacteria dysbiosis and its accompanying inflammation or compromised mucosal integrity is associated with an increased risk of HIV-1 transmission. However, HIV-1 may also bind bacteria or bacterial products to impact infectivity and transmi…
View article: Abstract 1982 Targeting Sialic Acids with Streptococcal Adhesin Proteins
Abstract 1982 Targeting Sialic Acids with Streptococcal Adhesin Proteins Open
Glycans terminating with sialic acid (sialoglycans) are important for many biological functions and are ubiquitous in both bacterial and mammalian cells. When found on mammalian cell surfaces one function is to act as ligands for sialic-ac…
View article: Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBR<sub>UB10712</sub>) of <i>Streptococcus gordonii</i>
Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBR<sub>UB10712</sub>) of <i>Streptococcus gordonii</i> Open
Streptococcus gordonii is a Gram-positive bacterial species that typically colonizes the human oral cavity, but can also cause local or systemic diseases. Serine-rich repeat (SRR) glycoproteins exposed on the S. gordonii bacterial surface …
View article: HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and resistance to neutralization by antibodies
HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and resistance to neutralization by antibodies Open
Bacteria dysbiosis has been associated with an increased risk of HIV-1 transmission and acquisition. The prevalent idea is that bacteria dysbiosis compromises mucosal integrity and promotes inflammatory conditions to cause recruitment and …
View article: HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and cell-to-cell viral transfer
HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and cell-to-cell viral transfer Open
While bacterial dysbiosis has been associated with increased HIV-1 transmission risk, little is known about direct associations between HIV-1 and bacteria. This study evaluated HIV-1 interactions with bacteria through glycan-binding lectin…
View article: Development and applications of sialoglycan-recognizing probes (SGRPs) with defined specificities: exploring the dynamic mammalian sialoglycome
Development and applications of sialoglycan-recognizing probes (SGRPs) with defined specificities: exploring the dynamic mammalian sialoglycome Open
Glycans that are abundantly displayed on vertebrate cell surface and secreted molecules are often capped with terminal sialic acids (Sias). These diverse 9-carbon-backbone monosaccharides are involved in numerous intrinsic biological proce…
View article: O-linked α2,3 sialylation defines stem cell populations in breast cancer
O-linked α2,3 sialylation defines stem cell populations in breast cancer Open
A specific cell surface glycan enables the identification of breast cancer stem cells and contributes to their function.
View article: Exosome microRNAs as liquid biopsies for the monitoring of prostate cancer
Exosome microRNAs as liquid biopsies for the monitoring of prostate cancer Open
Exosome microRNAs as liquid biopsies
View article: Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein associated with cardiac valve damage in animal models of infective endocarditis
Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein associated with cardiac valve damage in animal models of infective endocarditis Open
Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of tooth surfaces and are generally associated with oral health, but can also cause infective endocarditis (IE). These species express “Siglec-like” adhesins that bi…
View article: Development and applications of sialoglycan-recognizing probes (SGRPs) with defined specificities: exploring the dynamic mammalian sialoglycome
Development and applications of sialoglycan-recognizing probes (SGRPs) with defined specificities: exploring the dynamic mammalian sialoglycome Open
Glycans that are abundantly displayed on vertebrate cell surface and secreted molecules are often capped with terminal sialic acids (Sias). These diverse 9-carbon-backbone monosaccharides are involved in numerous intrinsic biological proce…
View article: Molecular recognition of sialoglycans by streptococcal Siglec-like adhesins: toward the shape of specific inhibitors
Molecular recognition of sialoglycans by streptococcal Siglec-like adhesins: toward the shape of specific inhibitors Open
We here present a detailed molecular description of sialoglycans recognition by Siglec-like adhesins from S. gordonii opening the venue for the design of specific inhibitors to influence the propensity of streptococci to cause infective en…
View article: O-acetylation controls the glycosylation of bacterial serine-rich repeat glycoproteins
O-acetylation controls the glycosylation of bacterial serine-rich repeat glycoproteins Open
The serine-rich repeat (SRR) glycoproteins of gram-positive bacteria are a family of adhesins that bind to a wide range of host ligands, and expression of SRR glycoproteins is linked with enhanced bacterial virulence. The biogenesis of the…
View article: Structure based virtual screening identifies small molecule effectors for the sialoglycan binding protein Hsa
Structure based virtual screening identifies small molecule effectors for the sialoglycan binding protein Hsa Open
Infective endocarditis (IE) is a cardiovascular disease often caused by bacteria of the viridans group of streptococci, which includes Streptococcus gordonii and Streptococcus sanguinis. Previous research has found that serine-rich repeat …
View article: Structure based virtual screening identifies novel competitive inhibitors for the sialoglycan binding protein Hsa
Structure based virtual screening identifies novel competitive inhibitors for the sialoglycan binding protein Hsa Open
Infective endocarditis (IE) is a cardiovascular disease often caused by bacteria of the viridans group of streptococci, which includes Streptococcus gordonii and Streptococcus sanguinis . Previous research has found that a serine-rich repe…
View article: Selectivity and engineering of the sialoglycan-binding spectrum in Siglec-like adhesins
Selectivity and engineering of the sialoglycan-binding spectrum in Siglec-like adhesins Open
The Siglec-like Serine-Rich Repeat (SRR) adhesins mediate bacterial attachment to mammalian hosts via sialoglycan receptors. Here, we combine structural, computational, biochemical, and phylogenetic approaches to elucidate the determinants…
View article: Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection
Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection Open
Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis. Both streptococcal species expr…
View article: The Two Distinct Types of SecA2-Dependent Export Systems
The Two Distinct Types of SecA2-Dependent Export Systems Open
In addition to SecA of the general Sec system, many Gram-positive bacteria, including mycobacteria, express SecA2, a second, transport-associated ATPase. SecA2s can be subdivided into two mechanistically distinct types: (i) SecA2s that are…
View article: The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins Open
Significance Mucin-domain glycoproteins are found in nearly every tissue of the human body, and are important in biological processes ranging from embryogenesis to cancer. Because there are few tools to study mucin domains, their biologica…
View article: Streptococcal Siglec-like adhesins recognize different subsets of human plasma glycoproteins: implications for infective endocarditis
Streptococcal Siglec-like adhesins recognize different subsets of human plasma glycoproteins: implications for infective endocarditis Open
Streptococcus gordonii and Streptococcus sanguinis are typically found among the normal oral microbiota but can also cause infective endocarditis. These organisms express cell surface serine-rich repeat adhesins containing "Siglec-like" bi…
View article: Serine-Rich Repeat Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets
Serine-Rich Repeat Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets Open
The binding of bacteria to platelets is thought to be a central event in the pathogenesis of infective endocarditis. The serine-rich repeat (SRR) glycoproteins of viridans group streptococci have been shown to mediate platelet binding in v…
View article: Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii
Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii Open
Many pathogenic bacteria, including Streptococcus gordonii, possess a pathway for the cellular export of a single serine-rich-repeat protein that mediates the adhesion of bacteria to host cells and the extracellular matrix. This adhesin pr…
View article: Structure and function of accessory Sec proteins involved in the adhesin export pathway of Streptococcus gordonii
Structure and function of accessory Sec proteins involved in the adhesin export pathway of Streptococcus gordonii Open
Many pathogenic bacteria, including Streptococcus gordonii , possess a pathway for the export of a single serine-rich-repeat protein that mediates the adhesion of bacteria to host cells and the extracellular matrix. These adhesins are O -g…