Barbara A. Cornblatt
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View article: Collecting language, speech acoustics, and facial expression to predict psychosis and other clinical outcomes: strategies from the AMP® SCZ initiative
Collecting language, speech acoustics, and facial expression to predict psychosis and other clinical outcomes: strategies from the AMP® SCZ initiative Open
View article: Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics
Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics Open
View article: The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures
The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures Open
View article: Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program
Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program Open
Although meta-analytic studies have shown that 25-33% of those at Clinical High Risk (CHR) for psychosis transition to a first episode of psychosis within three years, less is known about estimating the risk of transition at an individual …
View article: Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity
Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity Open
These findings suggest a role of episodic memory processing and inferior parietal lobe activation in the association between DT and psychosis. Focusing further on these measures could provide insight into the underlying mechanism of this a…
View article: Sample ascertainment and clinical outcome measures in the Accelerating Medicines Partnership® Schizophrenia Program
Sample ascertainment and clinical outcome measures in the Accelerating Medicines Partnership® Schizophrenia Program Open
Clinical ascertainment and clinical outcome are key features of any large multisite study. In the ProNET and PRESCIENT research networks, the Accelerating Medicines Partnership® Schizophrenia (AMP®SCZ) Clinical Ascert…
View article: The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program
The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program Open
Neuroimaging with MRI has been a frequent component of studies of individuals at clinical high risk (CHR) for developing psychosis, with goals of understanding potential brain regions and systems impacted in the CHR state and identifying p…
View article: Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample
Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample Open
Cognitive impairment occurs at higher rates in individuals at clinical high risk (CHR) for psychosis relative to healthy peers, and it contributes unique variance to multivariate prediction models of transition to psychosis. Such impairmen…
View article: Delineating empirically plausible causal pathways to suicidality among people at clinical high risk for psychosis.
Delineating empirically plausible causal pathways to suicidality among people at clinical high risk for psychosis. Open
Suicidality is common among people at clinical high risk (CHR) for psychosis. Delineating causal pathways to suicidality and identifying its determinants would inform tailored intervention efforts for these individuals. To this end, we ana…
View article: Predicting conversion to psychosis using machine learning: response to Cannon
Predicting conversion to psychosis using machine learning: response to Cannon Open
Background We previously reported that machine learning could be used to predict conversion to psychosis in individuals at clinical high risk (CHR) for psychosis with up to 90% accuracy using the North American Prodrome Longitudinal Study-…
View article: Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis
Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis Open
Background Antipsychotic (AP) medication in individuals at clinical high risk for psychosis (CHR-P) is not routinely recommended by clinical guidelines but is commonly prescribed. Since little is known about the predictors of AP inception …
View article: Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis.
Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis. Open
Mismatch negativity (MMN) event-related potential (ERP) component reduction, indexing N-methyl-D-aspartate receptor (NMDAR)-dependent auditory echoic memory and short-term plasticity, is a well-established biomarker of schizophrenia that i…
View article: Cognitive-Behavioural Social Skills Training: Mediation of Treatment Outcomes in a Randomized Controlled Trial for Youth at Risk of Psychosis: L’entraînement aux compétences sociales cognitivo-comportementales : variables médiatrices des résultats thérapeutiques dans le cadre d’un essai clinique randomisé pour les jeunes présentant un risque de psychose
Cognitive-Behavioural Social Skills Training: Mediation of Treatment Outcomes in a Randomized Controlled Trial for Youth at Risk of Psychosis: L’entraînement aux compétences sociales cognitivo-comportementales : variables médiatrices des résultats thérapeutiques dans le cadre d’un essai clinique randomisé pour les jeunes présentant un risque de psychose Open
Objectives Currently, there are no effective treatments for functional outcomes (i.e., role and social) and negative symptoms for youth at clinical high-risk (CHR) for psychosis. Investigations into possible mechanisms that may contribute …
View article: Attention Deficit Hyperactivity Disorder among Youth at Clinical High Risk of Psychosis
Attention Deficit Hyperactivity Disorder among Youth at Clinical High Risk of Psychosis Open
Attention Deficit Hyperactivity Disorder (ADHD) affects a significant proportion of the population and is associated with numerous adverse outcomes including lower educational attainment, occupational challenges, increased substance use, a…
View article: Cognitive subtypes in youth at clinical high risk for psychosis
Cognitive subtypes in youth at clinical high risk for psychosis Open
Introduction Schizophrenia is a mental health condition that severely impacts well-being. Cognitive impairment is among its core features, often presenting well before the onset of overt psychosis, underscoring a critical need to study it …
View article: Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition in Schizophrenia and Community-Based Samples
Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition in Schizophrenia and Community-Based Samples Open
Objective Schizophrenia is a neurodevelopmental disorder involving clinical and genetic heterogeneity. Multiple recurrent copy number variants (CNVs) increase risk for schizophrenia spectrum disorders (SSD). However, how known risk CNVs an…
View article: Occasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts
Occasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts Open
View article: Robust Brain Correlates of Cognitive Performance in Psychosis and Its Prodrome
Robust Brain Correlates of Cognitive Performance in Psychosis and Its Prodrome Open
This connectome-wide association study identified reproducible links between connectivity and cognition in separate samples of individuals with psychosis and at-risk individuals who would later develop psychosis. A carefully selected task …
View article: Sex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis
Sex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis Open
Sex differences have been observed in individuals with schizophrenia and for those at clinical high risk (CHR) for psychosis. However, specific differences in CHR individuals who transition to psychosis remain inconsistent and understudied…
View article: The Complex Latent Structure of Attenuated Psychotic Symptoms: Hierarchical and Bifactor Models of SIPS Symptoms Replicated in Two Large Samples at Clinical High Risk for Psychosis
The Complex Latent Structure of Attenuated Psychotic Symptoms: Hierarchical and Bifactor Models of SIPS Symptoms Replicated in Two Large Samples at Clinical High Risk for Psychosis Open
Background and Hypothesis The Structured Interview for Psychosis-Risk Syndromes (SIPS) and other assessments of psychosis risk define clinical high risk for psychosis (CHR) by the presence of attenuated psychotic symptoms. Despite extensiv…
View article: Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis
Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis Open
Background 22q11.2 Deletion Syndrome (22qDel) is a copy number variant (CNV) associated with psychosis and other neurodevelopmental disorders. Adolescents at clinical high risk for psychosis (CHR) have subthreshold psychosis symptoms witho…
View article: Plasma complement and coagulation proteins as prognostic factors of negative symptoms: An analysis of the NAPLS 2 and 3 studies
Plasma complement and coagulation proteins as prognostic factors of negative symptoms: An analysis of the NAPLS 2 and 3 studies Open
The results indicate that plasma complement and coagulation regulator levels are prognostic factors of negative symptoms, independent of clinical and demographic prognostic factors. These results suggest complement and coagulation regulato…
View article: The hierarchical taxonomy of psychopathology in clinical high risk for psychosis: Validation and extension.
The hierarchical taxonomy of psychopathology in clinical high risk for psychosis: Validation and extension. Open
The Hierarchical Taxonomy of Psychopathology (HiTOP) consortium's transdiagnostic dimensional model of psychopathology has considerable support; however, this model has been underresearched in individuals at clinical high risk for psychosi…
View article: Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis Open
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories a…
View article: Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis Open
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories a…
View article: Emergence and dynamics of delusions and hallucinations across stages in early psychosis
Emergence and dynamics of delusions and hallucinations across stages in early psychosis Open
Hallucinations and delusions are often grouped together within the positive symptoms of psychosis. However, recent evidence suggests they may be driven by distinct computational and neural mechanisms. Examining the time course of their eme…
View article: Negative self‐reference as a component of subthreshold psychotic symptoms in clinical high‐risk youth
Negative self‐reference as a component of subthreshold psychotic symptoms in clinical high‐risk youth Open
Aim Schizophrenia is a leading cause of disability worldwide; early detection and intervention are critical. Early in their illness, individuals at clinical high‐risk (CHR) for psychosis have subthreshold psychotic symptoms that are often …
View article: Proteomic Biomarkers for the Prediction of Transition to Psychosis in Individuals at Clinical High Risk: A Multi-cohort Model Development Study
Proteomic Biomarkers for the Prediction of Transition to Psychosis in Individuals at Clinical High Risk: A Multi-cohort Model Development Study Open
Psychosis risk prediction is one of the leading challenges in psychiatry. Previous investigations have suggested that plasma proteomic data may be useful in accurately predicting transition to psychosis in individuals at clinical high risk…
View article: Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms
Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms Open
We demonstrate that elevated HP is robustly observed in those at CHR for psychosis, irrespective of transition to psychosis. HP is longitudinally associated with poorer functioning and greater symptom severity. These results agree with pre…
View article: Autism and Interpersonal Difficulties in Individuals at Clinical High Risk for Psychosis
Autism and Interpersonal Difficulties in Individuals at Clinical High Risk for Psychosis Open