Barbara Belletti
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View article: Distinct 2-phenyl-imidazo[1, 2α] pyridine derivatives drive ER degradation and selectively impair proliferation of ER<sup>+</sup> breast cancer cells via the aryl hydrocarbon receptor
Distinct 2-phenyl-imidazo[1, 2α] pyridine derivatives drive ER degradation and selectively impair proliferation of ER<sup>+</sup> breast cancer cells via the aryl hydrocarbon receptor Open
X15695 is a 2-phenyl-imidazo[1, 2α] pyridine derivative identified as an orally active, selective oestrogen receptor (ER) degrader that inhibits the proliferation of ER + breast cancer cells. Here, we show that X15695 is an aryl hydrocarbo…
View article: Longitudinal profiling of hormone receptor positive, HER2 negative metastatic breast cancer through droplet digital PCR-based circulating tumor DNA fragmentomics
Longitudinal profiling of hormone receptor positive, HER2 negative metastatic breast cancer through droplet digital PCR-based circulating tumor DNA fragmentomics Open
View article: 128P Tumor markers and ctDNA fragmentomics: trend and prognostic role in HR+/HER2- metastatic breast cancer (mBC)
128P Tumor markers and ctDNA fragmentomics: trend and prognostic role in HR+/HER2- metastatic breast cancer (mBC) Open
View article: miR-1297 is frequently downmodulated in flat epithelial atypia of the breast and promotes mammary neoplastic transformation via EphrinA2 regulation
miR-1297 is frequently downmodulated in flat epithelial atypia of the breast and promotes mammary neoplastic transformation via EphrinA2 regulation Open
View article: Cyclin-dependent protein kinases and cell cycle regulation in biology and disease
Cyclin-dependent protein kinases and cell cycle regulation in biology and disease Open
Cyclin Dependent Kinases (CDKs) are closely connected to the regulation of cell cycle progression, having been first identified as the kinases able to drive cell division. In reality, the human genome contains 20 different CDKs, which can …
View article: Time-Varying Hazard Rates Reveal Patterns of Progression in HR+/HER2- Metastatic Breast Cancer: Towards Risk-Adapted Monitoring
Time-Varying Hazard Rates Reveal Patterns of Progression in HR+/HER2- Metastatic Breast Cancer: Towards Risk-Adapted Monitoring Open
View article: Chaga Mushroom Triterpenoids Inhibit Dihydrofolate Reductase and Act Synergistically with Conventional Therapies in Breast Cancer
Chaga Mushroom Triterpenoids Inhibit Dihydrofolate Reductase and Act Synergistically with Conventional Therapies in Breast Cancer Open
Inonotus obliquus (Chaga) is a medicinal mushroom with several pharmacological properties that is used as a tea in traditional Chinese medicine. In this study, Chaga water extract was digested in vitro to mimic the natural processing and a…
View article: USP1 deubiquitinates PARP1 to regulate its trapping and PARylation activity
USP1 deubiquitinates PARP1 to regulate its trapping and PARylation activity Open
PARP inhibitors (PARPi) represent a game-changing treatment for patients with ovarian cancer with tumors deficient for the homologous recombination (HR) pathway treated with platinum (Pt)–based therapy. PARPi exert their cytotoxic effect b…
View article: A comprehensive luminal breast cancer patient‐derived xenografts ( <scp>PDX</scp> ) library to capture tumor heterogeneity and explore the mechanisms of resistance to <scp>CDK4</scp> /6 inhibitors
A comprehensive luminal breast cancer patient‐derived xenografts ( <span>PDX</span> ) library to capture tumor heterogeneity and explore the mechanisms of resistance to <span>CDK4</span> /6 inhibitors Open
Breast cancer (BC) is marked by significant genetic, morphological and clinical heterogeneity. To capture this heterogeneity and unravel the molecular mechanisms driving tumor progression and drug resistance, we established a comprehensive…
View article: Author Correction: Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer
Author Correction: Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer Open
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View article: Insights into the structural and functional activities of forgotten Kinases: PCTAIREs CDKs
Insights into the structural and functional activities of forgotten Kinases: PCTAIREs CDKs Open
View article: Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer
Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer Open
Platinum (PT)-resistant Epithelial Ovarian Cancer (EOC) grows as a metastatic disease, disseminating in the abdomen and pelvis. Very few options are available for PT-resistant EOC patients, and little is known about how the acquisition of …
View article: L’Observatoire des Sédiments du Rhône. 12 années de recherche pour la connaissance et la gestion hydro-sédimentaire du fleuve. Bilans et perspectives scientifiques
L’Observatoire des Sédiments du Rhône. 12 années de recherche pour la connaissance et la gestion hydro-sédimentaire du fleuve. Bilans et perspectives scientifiques Open
International audience
View article: Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma
Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient supplies. PDAC aggressiveness largely relies on its extraordinary capability t…
View article: Loss of the extracellular matrix glycoprotein EMILIN1 accelerates Δ16HER2-driven breast cancer initiation in mice
Loss of the extracellular matrix glycoprotein EMILIN1 accelerates Δ16HER2-driven breast cancer initiation in mice Open
View article: Author Correction: Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth
Author Correction: Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth Open
View article: Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth
Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth Open
Reprogramming of amino acid metabolism, sustained by oncogenic signaling, is crucial for cancer cell survival under nutrient limitation. Here we discovered that missense mutant p53 oncoproteins stimulate de novo serine/glycine synthesis an…
View article: Loss of <i>CDKN1B</i> induces an age‐related clonal hematopoietic disorder via Notch2 activity dysregulation
Loss of <i>CDKN1B</i> induces an age‐related clonal hematopoietic disorder via Notch2 activity dysregulation Open
Dear Editor, The tumor suppressor gene CDKN1B, encoding for the p27Kip1 (p27) protein, defines the smallest region of deletion on chromosome 12p13 described in clonal hematopoietic disorders (CHDs) [1]. Among them, myelodysplastic syndrome…
View article: Supplementary Data from An Integrated Approach Identifies Mediators of Local Recurrence in Head and Neck Squamous Carcinoma
Supplementary Data from An Integrated Approach Identifies Mediators of Local Recurrence in Head and Neck Squamous Carcinoma Open
Supplementary Figure S1. Validation of differentially expressed miRs in the discovery dataset. Supplementary Figure S2. Design of a recurrence prediction model in HNSCC based on miRs expression using a bioinformatic approach. Supplementary…
View article: Video S1 from Stathmin Is Required for Normal Mouse Mammary Gland Development and Δ16HER2-Driven Tumorigenesis
Video S1 from Stathmin Is Required for Normal Mouse Mammary Gland Development and Δ16HER2-Driven Tumorigenesis Open
NMuMG CTR cells
View article: Supplementary Data from An Integrated Approach Identifies Mediators of Local Recurrence in Head and Neck Squamous Carcinoma
Supplementary Data from An Integrated Approach Identifies Mediators of Local Recurrence in Head and Neck Squamous Carcinoma Open
Supplementary Figure S1. Validation of differentially expressed miRs in the discovery dataset. Supplementary Figure S2. Design of a recurrence prediction model in HNSCC based on miRs expression using a bioinformatic approach. Supplementary…
View article: Data from Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer
Data from Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer Open
miR-223 is an anti-inflammatory miRNA that in cancer acts either as an oncosuppressor or oncopromoter, in a context-dependent manner. In breast cancer, we demonstrated that it dampens the activation of the EGF pathway. However, little is k…
View article: Data from Stathmin Is Required for Normal Mouse Mammary Gland Development and Δ16HER2-Driven Tumorigenesis
Data from Stathmin Is Required for Normal Mouse Mammary Gland Development and Δ16HER2-Driven Tumorigenesis Open
Postnatal development of the mammary gland relies on the maintenance of oriented cell division and apicobasal polarity, both of which are often deregulated in cancer. The microtubule (MT) network contributes to control these processes; how…
View article: Data from p27<sup>Kip1</sup> expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis
Data from p27<sup>Kip1</sup> expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis Open
The tumor suppressor gene CDKN1B encodes for a 27-kDa cyclin-dependent kinase inhibitory protein, p27Kip1, which together with its well-established role in the inhibition of cell proliferation, displays additional activit…
View article: Video S2 from Stathmin Is Required for Normal Mouse Mammary Gland Development and Δ16HER2-Driven Tumorigenesis
Video S2 from Stathmin Is Required for Normal Mouse Mammary Gland Development and Δ16HER2-Driven Tumorigenesis Open
NMuMG shSTM cells
View article: Data from Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding
Data from Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding Open
Purpose: After apparently successful excision of breast cancer, risk of local recurrence remains high mainly in the area surrounding the original tumor, indicating that wound healing processes may be implicated. The proportional red…
View article: Video S2 from Stathmin Is Required for Normal Mouse Mammary Gland Development and Δ16HER2-Driven Tumorigenesis
Video S2 from Stathmin Is Required for Normal Mouse Mammary Gland Development and Δ16HER2-Driven Tumorigenesis Open
NMuMG shSTM cells
View article: Data from p27<sup>Kip1</sup> expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis
Data from p27<sup>Kip1</sup> expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis Open
The tumor suppressor gene CDKN1B encodes for a 27-kDa cyclin-dependent kinase inhibitory protein, p27Kip1, which together with its well-established role in the inhibition of cell proliferation, displays additional activit…
View article: Supplementary Data from Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding
Supplementary Data from Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding Open
Supplementary Data from Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding
View article: Supplementary Figures 1-6, Supplementary Materials and Methods from Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer
Supplementary Figures 1-6, Supplementary Materials and Methods from Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer Open
Supplementary Information, Methods and Figures. Supplementary Figure 1. Loss of miR-223 does not alter the murine mammary gland architecture; Supplementary Figure 2. miR-223 KO mice do not display any proliferative advantage during â^†16HE…