Explanipedia

CORUM in 2024: protein complexes as drug targets Open

Ralph Steinkamp, George Tsitsiridis, Barbara Brauner, Corinna Montrone, Gisela Fobo , et al. · 2024

CORUM (https://mips.helmholtz-muenchen.de/corum/) is a public database that offers comprehensive information about mammalian protein complexes, including their subunits, functions and associations with human diseases. The newly released CO…

CORUM: the comprehensive resource of mammalian protein complexes–2022 Open

George Tsitsiridis, Ralph Steinkamp, Mădălina Giurgiu, Barbara Brauner, Gisela Fobo , et al. · 2022

The CORUM database has been providing comprehensive reference information about experimentally characterized, mammalian protein complexes and their associated biological and biomedical properties since 2007. Given that most catalytic and r…

Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease Open

Priyanka Baloni, Matthias Arnold, Luna Buitrago, Kwangsik Nho, Herman Moreno , et al. · 2022

Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer’s disease. Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are asso…

COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms Open

Marek Ostaszewski, Anna Niarakis, Alexander Mazein, Inna Kuperstein, Robert D. Phair , et al. · 2021

COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms Open

Marek Ostaszewski, Anna Niarakis, Alexander Mazein, Inna Kuperstein, Robert D. Phair , et al. · 2021

Multi-Omic Analyses Characterize the Ceramide/Sphingomyelin Pathway as a Therapeutic Target in Alzheimer’s Disease Open

Priyanka Baloni, Matthias Arnold, Herman Moreno, Kwangsik Nho, Luna Buitrago , et al. · 2021

Dysregulation of sphingomyelin (SM) and ceramide metabolism have been implicated in Alzheimer’s Disease (AD). Genome-wide and transcriptome wide association studies have identified various genes and genetic variants in lipid metabolism tha…

COVID-19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms (vol 17, e10387, 2021) Open

Marek Ostaszewski, Anna Niarakis, Alexander Mazein, Inna Kuperstein, Robert D. Phair , et al. · 2021

Graphical Abstract

COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms Open

Marek Ostaszewski, Anna Niarakis, Alexander Mazein, Inna Kuperstein, Robert D. Phair , et al. · 2020

We describe a large-scale community effort to build an open-access, interoperable, and computable repository of COVID-19 molecular mechanisms - the COVID-19 Disease Map. We discuss the tools, platforms, and guidelines necessary for the dis…

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome Open

Matthias Arnold, Kwangsik Nho, Alexandra Kueider‐Paisley, Tyler Massaro, Kevin Huynh , et al. · 2020

CORUM: the comprehensive resource of mammalian protein complexes—2019 Open

Mădălina Giurgiu, Julian Reinhard, Barbara Brauner, Irmtraud Dunger-Kaltenbach, Gisela Fobo , et al. · 2018

CORUM is a database that provides a manually curated repository of experimentally characterized protein complexes from mammalian organisms, mainly human (67%), mouse (15%) and rat (10%). Given the vital functions of these macromolecular ma…

PhenoDis: a comprehensive database for phenotypic characterization of rare cardiac diseases Open

Angela Adler, Pia Kirchmeier, Julian Reinhard, Barbara Brauner, Irmtraud Dunger , et al. · 2018

Systematic Identification of Pharmacological Targets from Small-Molecule Phenotypic Screens Open

Xueping Liu, Hoeke A. Baarsma, Chung Hwee Thiam, Corinna Montrone, Barbara Brauner , et al. · 2016

Barbara Brauner YOU? Author Swipe