Barbara Carl
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View article: Long-term effects of invasive and transcutaneous vagus nerve stimulation in patients with epilepsy: a retrospective cohort study
Long-term effects of invasive and transcutaneous vagus nerve stimulation in patients with epilepsy: a retrospective cohort study Open
Objective To compare the long-term effects of transcutaneous vagus nerve stimulation (tVNS) and invasive vagus nerve stimulation (iVNS) on seizure frequency and tolerability in patients with drug-resistant epilepsies. Methods A retrospecti…
View article: Intraoperative Computed Tomography, Ultrasound, and Augmented Reality in Mesial Temporal Lobe Epilepsy Surgery—A Retrospective Cohort Study
Intraoperative Computed Tomography, Ultrasound, and Augmented Reality in Mesial Temporal Lobe Epilepsy Surgery—A Retrospective Cohort Study Open
Mesial temporal lobe epilepsy (mTLE) surgery, particularly selective amygdalohippocampectomy (sAHE), is a recognized treatment for pharmacoresistant temporal lobe epilepsy (TLE). Accurate intraoperative orientation is crucial for complete …
View article: A comparison of long-term outcomes between interposition with Teflon and autologous muscle in microvascular decompression for trigeminal neuralgia
A comparison of long-term outcomes between interposition with Teflon and autologous muscle in microvascular decompression for trigeminal neuralgia Open
Objective: Microvascular decompression (MVD) is an established surgical procedure for treating classical trigeminal neuralgia (TN) by separating the trigeminal nerve from an offending vessel. Various materials can be used for interposition…
View article: Frameless Stereotaxy in Stereoelectroencephalography Using Intraoperative Computed Tomography
Frameless Stereotaxy in Stereoelectroencephalography Using Intraoperative Computed Tomography Open
Background: Pharmacoresistant epilepsy affects approximately one-third of all epilepsy patients, and resective surgery may offer favorable outcomes for carefully selected patients with focal epilepsy. The accurate identification of the epi…
View article: Radiation exposure in neurosurgical intensive care unit patients: Balancing diagnostic benefits and long-term risks
Radiation exposure in neurosurgical intensive care unit patients: Balancing diagnostic benefits and long-term risks Open
While radiation exposure in NICU patients is substantial, the benefits of timely and accurate diagnostic information outweigh the potential long-term risks. In critical care settings, where patients face life-threatening conditions, the ju…
View article: Augmented Reality in Extratemporal Lobe Epilepsy Surgery
Augmented Reality in Extratemporal Lobe Epilepsy Surgery Open
Background: Epilepsy surgery for extratemporal lobe epilepsy (ETLE) is challenging, particularly when MRI findings are non-lesional and seizure patterns are complex. Invasive diagnostic techniques are crucial for accurately identifying the…
View article: Diffuse Leptomeningeal Glioneuronal Tumor in Adults: Case Report and Literature Review
Diffuse Leptomeningeal Glioneuronal Tumor in Adults: Case Report and Literature Review Open
Introduction: Diffuse leptomeningeal glioneuronal tumor (DLGNT), a new addition to the 2016 World Health Organization (WHO) classification, is a rare childhood neoplasm presenting with disseminated leptomeningeal enhancement and an occasio…
View article: Neurosurgical care for patients with high-grade gliomas during the coronavirus disease 2019 pandemic: Analysis of routine billing data of a German nationwide hospital network
Neurosurgical care for patients with high-grade gliomas during the coronavirus disease 2019 pandemic: Analysis of routine billing data of a German nationwide hospital network Open
Background Little is known about delivery of neurosurgical care, complication rate and outcome of patients with high-grade glioma (HGG) during the coronavirus disease 2019 (Covid-19) pandemic. Methods This observational, retrospective coho…
View article: Microscope-Based Augmented Reality with Intraoperative Computed Tomography-Based Navigation for Resection of Skull Base Meningiomas in Consecutive Series of 39 Patients
Microscope-Based Augmented Reality with Intraoperative Computed Tomography-Based Navigation for Resection of Skull Base Meningiomas in Consecutive Series of 39 Patients Open
Background: The aim of surgery for skull base meningiomas is maximal resection with minimal damage to the involved cranial nerves and cerebral vessels; thus, implementation of technologies for improved orientation in the surgical field, su…
View article: The Metalloprotease-Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its Aggressiveness
The Metalloprotease-Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its Aggressiveness Open
Glioblastoma (GBM) as the most common and aggressive brain tumor is characterized by genetic heterogeneity, invasiveness, radio-/chemoresistance, and occurrence of GBM stem-like cells. The metalloprotease-disintegrin ADAM8 is highly expres…
View article: Radiogenomic Predictors of Recurrence in Glioblastoma—A Systematic Review
Radiogenomic Predictors of Recurrence in Glioblastoma—A Systematic Review Open
Glioblastoma, as the most aggressive brain tumor, is associated with a poor prognosis and outcome. To optimize prognosis and clinical therapy decisions, there is an urgent need to stratify patients with increased risk for recurrent tumors …
View article: Initial Intraoperative Experience with Robotic-Assisted Pedicle Screw Placement with Cirq® Robotic Alignment: An Evaluation of the First 70 Screws
Initial Intraoperative Experience with Robotic-Assisted Pedicle Screw Placement with Cirq® Robotic Alignment: An Evaluation of the First 70 Screws Open
Background: Robot-guided spine surgery is based on a preoperatively planned trajectory that is reproduced in the operating room by the robotic device. This study presents our initial experience with thoracolumbar pedicle screw placement us…
View article: Utilizing Intraoperative Navigated 3D Color Doppler Ultrasound in Glioma Surgery
Utilizing Intraoperative Navigated 3D Color Doppler Ultrasound in Glioma Surgery Open
Background In glioma surgery, the patient’s outcome is dramatically influenced by the extent of resection and residual tumor volume. To facilitate safe resection, neuronavigational systems are routinely used. However, due to brain shift, a…
View article: Neurosurgical Management and Outcome Parameters in 237 Patients with Spondylodiscitis
Neurosurgical Management and Outcome Parameters in 237 Patients with Spondylodiscitis Open
Surgical treatment of spondylodiscitis allows for rapid mobilization and shortens hospital stays, which makes surgical treatment the first-line therapy. We aim to describe our experiences with operative treatment on spondylodiscitis and to…
View article: Intraoperative Computed Tomography-Based Navigation with Augmented Reality for Lateral Approaches to the Spine
Intraoperative Computed Tomography-Based Navigation with Augmented Reality for Lateral Approaches to the Spine Open
Background. Lateral approaches to the spine have gained increased popularity due to enabling minimally invasive access to the spine, less blood loss, decreased operative time, and less postoperative pain. The objective of the study was to …
View article: Diffusion Kurtosis Imaging Fiber Tractography of Major White Matter Tracts in Neurosurgery
Diffusion Kurtosis Imaging Fiber Tractography of Major White Matter Tracts in Neurosurgery Open
Diffusion tensor imaging (DTI)-based fiber tractography is routinely used in clinical applications to visualize major white matter tracts, such as the corticospinal tract (CST), optic radiation (OR), and arcuate fascicle (AF). Nevertheless…
View article: Extreme lateral interbody fusion (XLIF) in a consecutive series of 72 patients
Extreme lateral interbody fusion (XLIF) in a consecutive series of 72 patients Open
Extreme lateral interbody fusion (XLIF) has become the standard of minimally invasive lumbar segmental scoliosis treatment. Our objective is to determine the safety and efficacy of XLIF in spinal canal stenosis (SCS) and spondylodiscitis (…
View article: Application of an Expandable Cage for Reconstruction of the Cervical Spine in a Consecutive Series of Eighty-Six Patients
Application of an Expandable Cage for Reconstruction of the Cervical Spine in a Consecutive Series of Eighty-Six Patients Open
Background and objectives: Expandable cages are frequently used to reconstruct the anterior spinal column after a corpectomy. In this retrospective study, we evaluated the perioperative advantages and disadvantages of corpectomy reconstruc…
View article: Navigated 3D Ultrasound in Brain Metastasis Surgery: Analyzing the Differences in Object Appearances in Ultrasound and Magnetic Resonance Imaging
Navigated 3D Ultrasound in Brain Metastasis Surgery: Analyzing the Differences in Object Appearances in Ultrasound and Magnetic Resonance Imaging Open
Background: Implementation of intraoperative 3D ultrasound (i3D US) into modern neuronavigational systems offers the possibility of live imaging and subsequent imaging updates. However, different modalities, image acquisition strategies, a…
View article: Comparing Fiducial-Based and Intraoperative Computed Tomography-Based Registration for Frameless Stereotactic Brain Biopsy
Comparing Fiducial-Based and Intraoperative Computed Tomography-Based Registration for Frameless Stereotactic Brain Biopsy Open
Objective: The aim of this work was to compare fiducial-based and intraoperative computed tomography (iCT)-based registration for frameless stereotactic brain biopsy. Methods: Of 50 frameless stereotactic biopsies with the VarioGuide, 30 c…
View article: <i>ADAM8</i> affects glioblastoma progression by regulating osteopontin-mediated angiogenesis
<i>ADAM8</i> affects glioblastoma progression by regulating osteopontin-mediated angiogenesis Open
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer with a median survival of only 15 months. To complement standard treatments including surgery, radiation and chemotherapy, it is essential to understand the contribu…
View article: The impact of position-orientation adaptive smoothing in diffusion weighted imaging—From diffusion metrics to fiber tractography
The impact of position-orientation adaptive smoothing in diffusion weighted imaging—From diffusion metrics to fiber tractography Open
In contrast to commonly used approaches to improve data quality in diffusion weighted imaging, position-orientation adaptive smoothing (POAS) provides an edge-preserving post-processing approach. This study aims to investigate its potentia…
View article: Spine Surgery Supported by Augmented Reality
Spine Surgery Supported by Augmented Reality Open
Study Design: A prospective, case-based, observational study. Objectives: To investigate how microscope-based augmented reality (AR) support can be utilized in various types of spine surgery. Methods: In 42 spinal procedures (12 intra- and…
View article: <p>Carbon Ion Beam Reirradiation in Recurrent High-Grade Glioma</p>
Carbon Ion Beam Reirradiation in Recurrent High-Grade Glioma Open
Carbon ion reirradiation in recurrent high-grade glioma is safe and feasible. No radiation-associated grade 4 toxicities were documented and treatment was tolerated well.
View article: Reliable navigation registration in cranial and spine surgery based on intraoperative computed tomography
Reliable navigation registration in cranial and spine surgery based on intraoperative computed tomography Open
OBJECTIVE Low registration errors are an important prerequisite for reliable navigation, independent of its use in cranial or spinal surgery. Regardless of whether navigation is used for trajectory alignment in biopsy or implant procedures…
View article: Outcome after Interdisciplinary Treatment for Aneurysmal Subarachnoid Hemorrhage—A Single Center Experience
Outcome after Interdisciplinary Treatment for Aneurysmal Subarachnoid Hemorrhage—A Single Center Experience Open
Background and Objectives: To identify predictors of outcome after aneurysmal subarachnoid hemorrhage (aSAH) in our interdisciplinary setting. Materials and Methods: 176 patients who had been treated for aSAH by a team of neurosurgeons and…
View article: Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor
Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor Open
About 95% of patients with Glioblastoma (GBM) show tumor relapse, leaving them with limited therapeutic options as recurrent tumors are most often resistant to the first line chemotherapy standard Temozolomide (TMZ). To identify molecular …