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View article: Non-Coding RNAs as Potential Diagnostic/Prognostic Markers for Hepatocellular Carcinoma
Non-Coding RNAs as Potential Diagnostic/Prognostic Markers for Hepatocellular Carcinoma Open
The increasing incidence of hepatocellular carcinoma (HCC), together with the poor effectiveness of the available treatments, make early diagnosis and effective screening of utmost relevance. Liquid biopsy represents a potential novel appr…
View article: Non-Coding RNAs as Potential Diagnostic/Prognostic Markers for Hepatocellular Carcinoma
Non-Coding RNAs as Potential Diagnostic/Prognostic Markers for Hepatocellular Carcinoma Open
The increasing incidence of hepatocellular carcinoma (HCC) together with the poor effectiveness of the available therapeutic treatments, make an early diagnosis and an effective screening of utmost relevance. Liquid biopsy represents a pot…
View article: In Vitro and In Vivo Evaluation of the Effects of Drug 2c and Derivatives on Ovarian Cancer Cells
In Vitro and In Vivo Evaluation of the Effects of Drug 2c and Derivatives on Ovarian Cancer Cells Open
Background: The identification of novel therapeutic strategies for ovarian cancer (OC), the most lethal gynecological neoplasm, is of utmost urgency. Here, we have tested the effectiveness of the compound 2c (4-hydroxy-2,6-bis(4-nitrobenzy…
View article: In Vitro and In Vivo Evaluation of the Effects of Drug 2c and Derivatives on Ovarian Cancer Cells
In Vitro and In Vivo Evaluation of the Effects of Drug 2c and Derivatives on Ovarian Cancer Cells Open
Background: The identification of novel therapeutic strategies for Ovarian cancer (OC), the most lethal gynecological neoplasm, is of utmost urgency. Here, we have tested the effectiveness of the compound 2c (4-Hydroxy-2,6-bis(4-nitrobenzy…
View article: Plasma Circular RNAs as Biomarkers for Breast Cancer
Plasma Circular RNAs as Biomarkers for Breast Cancer Open
Breast cancer (BC) is currently the most common neoplasm, the second leading cause of cancer death in women worldwide, and is a major health problem. The discovery of new biomarkers is crucial to improve our knowledge of breast cancer and …
View article: Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases
Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases Open
The respiratory mucus, a viscoelastic gel, effectuates a primary line of the airway defense when operated by the mucociliary clearance. In chronic respiratory diseases (CRDs), such as asthma, chronic obstructive pulmonary disease (COPD), a…
View article: Targeting Non-Coding RNAs for the Development of Novel Hepatocellular Carcinoma Therapeutic Approaches
Targeting Non-Coding RNAs for the Development of Novel Hepatocellular Carcinoma Therapeutic Approaches Open
Hepatocellular carcinoma (HCC) remains a global health challenge, representing the third leading cause of cancer deaths worldwide. Although therapeutic advances have been made in the few last years, the prognosis remains poor. Thus, there …
View article: Nanomechanical Characterization of Ovarian Cancer Cell Lines as a Marker of Response to 2c Treatment
Nanomechanical Characterization of Ovarian Cancer Cell Lines as a Marker of Response to 2c Treatment Open
Epithelial ovarian cancers (EOCs) are a heterogeneous group of tumors with different molecular and clinical features. In past decades, few improvements have been achieved in terms of EOC management and treatment efficacy, such that the 5-y…
View article: High eEF1A1 Protein Levels Mark Aggressive Prostate Cancers and the In Vitro Targeting of eEF1A1 Reveals the eEF1A1–actin Complex as a New Potential Target for Therapy
High eEF1A1 Protein Levels Mark Aggressive Prostate Cancers and the In Vitro Targeting of eEF1A1 Reveals the eEF1A1–actin Complex as a New Potential Target for Therapy Open
Although the eukaryotic elongation factor eEF1A1 plays a role in various tumours, there is little information on its prognosis/therapeutic value in prostate carcinoma. In high-grade and castration-resistant prostate carcinoma (CRPC), the i…
View article: An Overview of siRNA Delivery Strategies for Urological Cancers
An Overview of siRNA Delivery Strategies for Urological Cancers Open
The treatment of urological cancers has been significantly improved in recent years. However, for the advanced stages of these cancers and/or for those developing resistance, novel therapeutic options need to be developed. Among the innova…
View article: 5-Azacytidine Downregulates the Proliferation and Migration of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Targeting miR-139-5p/ROCK2 Pathway
5-Azacytidine Downregulates the Proliferation and Migration of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Targeting miR-139-5p/ROCK2 Pathway Open
Background: For hepatocellular carcinoma (HCC), effective therapeutic approaches are lacking. As aberrant gene methylation is a major contributor to HCC development, demethylating drugs such as 5-azacytidine (5-Aza) have been proposed. As …
View article: Xenograft Zebrafish Models for the Development of Novel Anti-Hepatocellular Carcinoma Molecules
Xenograft Zebrafish Models for the Development of Novel Anti-Hepatocellular Carcinoma Molecules Open
Hepatocellular carcinoma (HCC) is the sixth most common type of tumor and the second leading cause of tumor-related death worldwide. Liver cirrhosis is the most important predisposing factor for HCC. Available therapeutic approaches are no…
View article: Strategies for Delivery of siRNAs to Ovarian Cancer Cells
Strategies for Delivery of siRNAs to Ovarian Cancer Cells Open
The unmet need for novel therapeutic options for ovarian cancer (OC) deserves further investigation. Among the different novel drugs, small interfering RNAs (siRNAs) are particularly attractive because of their specificity of action and ef…
View article: E2F1 as a molecular drug target in ovarian cancer
E2F1 as a molecular drug target in ovarian cancer Open
Ovarian cancer (OC) is the most lethal gynecological neoplasm in the world. From the histological point of view, OC is subdivided into type I and II [1]. Type I includes distinct tumor subtypes, i.e. low-grade serous carcinoma (LGSC), endo…
View article: Can rheology be useful in the cystic fibrosis frame
Can rheology be useful in the cystic fibrosis frame Open
Lung functionality assessment in cystic fibrosis (CF) patients is extremely relevant as most patients succumb to respiratory failure. Inflammatory markers (IMs) and respiratory functional tests, i.e. forced expiratory volume in the first s…
View article: Effects of Hypoxia and Bed Rest on Markers of Cardiometabolic Risk: Compensatory Changes in Circulating TRAIL and Glutathione Redox Capacity
Effects of Hypoxia and Bed Rest on Markers of Cardiometabolic Risk: Compensatory Changes in Circulating TRAIL and Glutathione Redox Capacity Open
In chronic diseases, hypoxia and physical inactivity are associated with atherosclerosis progression. In contrast, a lower mortality from coronary artery disease and stroke is observed in healthy humans residing at high altitude in hypoxic…
View article: Polymer-Mediated Delivery of siRNAs to Hepatocellular Carcinoma: Variables Affecting Specificity and Effectiveness
Polymer-Mediated Delivery of siRNAs to Hepatocellular Carcinoma: Variables Affecting Specificity and Effectiveness Open
Despite the advances in anticancer therapies, their effectiveness for many human tumors is still far from being optimal. Significant improvements in treatment efficacy can come from the enhancement of drug specificity. This goal may be ach…
View article: Potential Applications of Nanocellulose-Containing Materials in the Biomedical Field
Potential Applications of Nanocellulose-Containing Materials in the Biomedical Field Open
Because of its high biocompatibility, bio-degradability, low-cost and easy availability, cellulose finds application in disparate areas of research. Here we focus our attention on the most recent and attractive potential applications of ce…
View article: Mathematical Modeling of Drug Release from Natural Polysaccharides Based Matrices
Mathematical Modeling of Drug Release from Natural Polysaccharides Based Matrices Open
The new concept of personalized medicine and the affirmation of Nucleic Acid Based Drugs (NABDs), an emerging class of bio-drugs constituted by short sequences of either DNA or RNA, represent a new challenge for the mathematical modelling …
View article: Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals
Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals Open
The control of cancer onset and progression is recognized to benefit from specific molecular targeting. MiRNAs are increasingly being implicated in prostate cancer, and the evidence suggests they are possible targets for molecular therapy …