Barbara Franceschini
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View article: Supplementary Table S4 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis
Supplementary Table S4 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis Open
Supplementary Table S4
View article: Supplementary Table S2 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis
Supplementary Table S2 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis Open
Supplementary Table S2
View article: Supplementary Table S3 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis
Supplementary Table S3 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis Open
Supplementary Table S3
View article: Figure S2 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S2 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 2. Transcriptomic characterization of healthy liver and Kupffer cells
View article: Data from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Data from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Early synchronous colorectal liver metastasis (CRLM) represents a clinical condition characterized by the simultaneous presence of primary colorectal cancer and metastatic liver lesions. In this study, we characterized the tissue-specific …
View article: Figure S3 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S3 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 3. Transcriptomic characterization of pathologic and healthy monocytes in the peripheral blood
View article: Figure S5 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S5 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 5. Differences between inflammatory and immunoregulatory TAMs in colon and liver
View article: Table S1 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Table S1 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Table 1. List of significant genes (FDR-adjusted p-value < 0.05, and |Log2-FoldChange| > 0.25, detected in not less than 10% of cells) identified from in each tissue-specific cluster within pathologic colon, liver, and periph…
View article: Table S4 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Table S4 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Table 4. List of genes used to compute the gene module scores related to the cell cycle proliferation score (n genes = 57). Table related to Fig. 5D.
View article: Table S3 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Table S3 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Table 3. List of significant genes (FDR-adjusted p-value < 0.05, and |Log2-FoldChange| > 0.25, detected in not less than 10% of cells) identified from the comparison Liver vs Colon within the inflammatory or immunoregulatory …
View article: Figure S1 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S1 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 1. scRNA-sequencing analysis of early phases synchronous CRLM patients
View article: Figure S4 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S4 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 4. Pseudotime trajectory analysis shows macrophage blood derivation
View article: Table S2 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Table S2 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Table S2: List of genes used to compute the gene module scores related to the antigen-presentation (n genes = 24), lipid-associated (n genes = 32), angiogenic (n genes = 31<…
View article: Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome
Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome Open
Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive biliary tract cancer with a poor prognosis and a complex tumour microenvironment (TME) that remains poorly understood. Objective This study aimed to investigate the p…
View article: Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Early synchronous colorectal liver metastasis (CRLM) represents a clinical condition characterized by the simultaneous presence of primary colorectal cancer and metastatic liver lesions. In this study, we characterized the tissue-specific …
View article: Refinement of histologic subtypes and identification of biomarkers linked to unfavorable prognosis in cholangiocarcinoma: The ENSCCA registries’ framework for digital twin advancement
Refinement of histologic subtypes and identification of biomarkers linked to unfavorable prognosis in cholangiocarcinoma: The ENSCCA registries’ framework for digital twin advancement Open
Background and Aims: Cholangiocarcinoma (CCA) displays remarkable anatomical and histological heterogeneity. Besides diagnosis confirmation, histology currently does not have a major role in the management of CCA. We aimed to study the cli…
View article: Unveiling the prognostic role of blood inflammatory indexes in a retrospective cohort of patients undergoing liver resection for intrahepatic cholangiocarcinoma
Unveiling the prognostic role of blood inflammatory indexes in a retrospective cohort of patients undergoing liver resection for intrahepatic cholangiocarcinoma Open
Background: Systemic inflammation is relevant in intrahepatic cholangiocarcinoma (iCCA), but controversial results exist on the prognostic role of inflammatory indexes and their correlation with tumor microenvironment. The authors aimed to…
View article: Riboflavin-LSD1 axis participates in the in vivo tumor-associated macrophage morphology in human colorectal liver metastases
Riboflavin-LSD1 axis participates in the in vivo tumor-associated macrophage morphology in human colorectal liver metastases Open
View article: Behavior of Listeria monocytogenes during the Shelf-life of Fresh Refrigerated Pesto Sauce, According to Regulation (EU) 2073/2005 and Subsequent Amendments
Behavior of Listeria monocytogenes during the Shelf-life of Fresh Refrigerated Pesto Sauce, According to Regulation (EU) 2073/2005 and Subsequent Amendments Open
Aims: Ligurian pesto is one of the most popular condiments for pasta. For microbiological purposes, refrigerated pesto sauce is a great matter for concern, as it can be contaminated by microorganisms originating from both raw materials and…
View article: Dataset related to article "Filamin A is involved in human intrahepatic cholangiocarcinoma aggressiveness and progression"
Dataset related to article "Filamin A is involved in human intrahepatic cholangiocarcinoma aggressiveness and progression" Open
<p>This record contains raw data related to article “Filamin A is involved in human intrahepatic cholangiocarcinoma aggressiveness and progression"</p>\n<p><strong>Abstract</strong></p>\n<div>…
View article: Cellular Senescence in Liver Cancer: How Dying Cells Become “Zombie” Enemies
Cellular Senescence in Liver Cancer: How Dying Cells Become “Zombie” Enemies Open
Liver cancer represents the fourth leading cause of cancer-associated death worldwide. The heterogeneity of its tumor microenvironment (TME) is a major contributing factor of metastasis, relapse, and drug resistance. Regrettably, late diag…
View article: Dataset related to article "High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis"
Dataset related to article "High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis" Open
<p>This record contains raw data related to article "High-resolution analysis of mononuclear phagocytes reveals GPNMB as a prognostic marker in human colorectal liver metastasis"</p><p><strong>Abstract</strong>…
View article: Dataset related to article "High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis"
Dataset related to article "High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis" Open
<p>This record contains raw data related to article "High-resolution analysis of mononuclear phagocytes reveals GPNMB as a prognostic marker in human colorectal liver metastasis"</p><p><strong>Abstract</strong>…
View article: Dataset related to article "Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis"
Dataset related to article "Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis" Open
Dataset related to article "Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis"AbstractHepatic metastasis is a clinical challenge for colorectal cancer (CRC). Senescent cancer cells acc…
View article: Filamin A is involved in human intrahepatic cholangiocarcinoma aggressiveness and progression
Filamin A is involved in human intrahepatic cholangiocarcinoma aggressiveness and progression Open
Background & Aims Intrahepatic cholangiocarcinoma (iCCA) is a primary liver tumour, characterized by poor prognosis and lack of effective therapy. The cytoskeleton protein Filamin A (FLNA) is involved in cancer progression and metastasis, …
View article: Cholangiocarcinoma-on-a-chip: A human 3D platform for personalised medicine
Cholangiocarcinoma-on-a-chip: A human 3D platform for personalised medicine Open
View article: Implication of metabolism in the polarization of tumor-associated-macrophages: the mass spectrometry-based point of view
Implication of metabolism in the polarization of tumor-associated-macrophages: the mass spectrometry-based point of view Open
Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and alternativ…
View article: Featured Cover
Featured Cover Open
Cover legend: The cover image is based on the Research Article Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis by Ombretta Garbarino et al., https://doi.org/10.1111/acel.13853 [Image: see text]
View article: The combination of blood inflammatory indexes predicts survivals in patients undergoing resection for intrahepatic cholangiocarcinoma
The combination of blood inflammatory indexes predicts survivals in patients undergoing resection for intrahepatic cholangiocarcinoma Open
Flavio MILANA*, Matteo DONADON, Michela Anna POLIDORO, Cristiana SOLDANI, Barbara FRANCESCHINI, Guido TORZILLI. Ann Hepatobiliary Pancreat Surg 2023;27:S167. https://doi.org/10.14701/ahbps.2023S1.LV-PP-1-2
View article: Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes
Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes Open