Barbara Katharina Geist
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View article: Whole-Body [18F]FDG-PET/CT Imaging of Healthy Controls: Test/Retest Data for Systemic, Multi-Organ Analysis
Whole-Body [18F]FDG-PET/CT Imaging of Healthy Controls: Test/Retest Data for Systemic, Multi-Organ Analysis Open
Positron Emission Tomography (PET) with 2-deoxy-2-[ 18 F]fluoro-D-glucose (FDG) and Computed Tomography (CT) are key tools in oncology diagnostics. However, most PET studies focus on tumour detection. We propose that a holistic assessment …
View article: The metabolic organ connectome: A novel approach to measure allostatic load during health-to-disease transition
The metabolic organ connectome: A novel approach to measure allostatic load during health-to-disease transition Open
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
View article: Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative
Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative Open
View article: Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative
Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative Open
We present a large whole-body and total-body curated dataset of dual-modality 2-deoxy-2-[18F]fluoro-D-glucose (FDG)-Positron Emission Tomography/Computed Tomography (PET/CT) studies, consisting of 1,597 PET/CT images and the corresponding …
View article: Development of quantitative PET/MR imaging for measurements of hepatic portal vein input function: a phantom study
Development of quantitative PET/MR imaging for measurements of hepatic portal vein input function: a phantom study Open
The proposed protocol demonstrates clinically feasible PET/MR imaging of the liver for pharmacokinetic studies with accurate quantification of the portal vein input function, including correction for respiratory motion and partial volume e…
View article: Systemic Metabolic and Volumetric Assessment via Whole-Body [18F]FDG-PET/CT: Pancreas Size Predicts Cachexia in Head and Neck Squamous Cell Carcinoma
Systemic Metabolic and Volumetric Assessment via Whole-Body [18F]FDG-PET/CT: Pancreas Size Predicts Cachexia in Head and Neck Squamous Cell Carcinoma Open
Background/Objectives: Cancer-associated cachexia in head and neck squamous cell carcinoma (HNSCC) is challenging to diagnose due to its complex pathophysiology. This study aimed to identify metabolic biomarkers linked to cachexia and surv…
View article: In vivo assessment of safety, biodistribution, and radiation dosimetry of the [18F]Me4FDG PET-radiotracer in adults
In vivo assessment of safety, biodistribution, and radiation dosimetry of the [18F]Me4FDG PET-radiotracer in adults Open
View article: Assessment of PSMA Expression of Healthy Organs in Different Stages of Prostate Cancer Using [68Ga]Ga-PSMA-11-PET Examinations
Assessment of PSMA Expression of Healthy Organs in Different Stages of Prostate Cancer Using [68Ga]Ga-PSMA-11-PET Examinations Open
The efficacy of radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA) is currently being investigated for its application in patients with early-stage prostate cancer (PCa). However, little is known about PSMA expre…
View article: Low-dose and standard-dose whole-body [18F]FDG-PET/CT imaging: implications for healthy controls and lung cancer patients
Low-dose and standard-dose whole-body [18F]FDG-PET/CT imaging: implications for healthy controls and lung cancer patients Open
Aim: High-sensitivity hybrid positron emission tomography (PET) imaging using advanced whole-body (WB) or total-body PET/computed tomography (CT) systems permits reducing injected tracer activity while preserving diagnostic quality. Such a…
View article: A fingerprint of 2-[18F]FDG radiometabolites – How tissue-specific metabolism beyond 2-[18F]FDG-6-P could affect tracer accumulation
A fingerprint of 2-[18F]FDG radiometabolites – How tissue-specific metabolism beyond 2-[18F]FDG-6-P could affect tracer accumulation Open
Studies indicate that the radiotracer 2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG) can be metabolized beyond 2-[18F]FDG-6-phosphate (2-[18F]FDG-6-P), but its metabolism is incompletely understood…
View article: Direct Patlak Reconstruction of [68Ga]Ga-PSMA PET for the Evaluation of Primary Prostate Cancer Prior Total Prostatectomy: Results of a Pilot Study
Direct Patlak Reconstruction of [68Ga]Ga-PSMA PET for the Evaluation of Primary Prostate Cancer Prior Total Prostatectomy: Results of a Pilot Study Open
To investigate the use of kinetic parameters derived from direct Patlak reconstructions of [68Ga]Ga-PSMA-11 positron emission tomography/computed tomography (PET/CT) to predict the histological grade of malignancy of the primary tumor of p…
View article: Excretion of glucose analogue with SGLT2 affinity predicts response effectiveness to sodium glucose transporter 2 inhibitors in patients with type 2 diabetes mellitus
Excretion of glucose analogue with SGLT2 affinity predicts response effectiveness to sodium glucose transporter 2 inhibitors in patients with type 2 diabetes mellitus Open
View article: Comparison of cardiac image-derived input functions for quantitative whole body [18F]FDG imaging with arterial blood sampling
Comparison of cardiac image-derived input functions for quantitative whole body [18F]FDG imaging with arterial blood sampling Open
Introduction: Dynamic positron emission tomography (PET) and the application of kinetic models can provide important quantitative information based on its temporal information. This however requires arterial blood sampling, which can be ch…
View article: Whole-body metabolic connectivity framework with functional PET
Whole-body metabolic connectivity framework with functional PET Open
The nervous and circulatory system interconnects the various organs of the human body, building hierarchically organized subsystems, enabling fine-tuned, metabolically expensive brain-body and inter-organ crosstalk to appropriately adapt t…
View article: Peer Review #1 of "Tubular epithelial progenitors are excreted in urine during recovery from severe acute kidney injury and are able to expand and differentiate in vitro (v0.1)"
Peer Review #1 of "Tubular epithelial progenitors are excreted in urine during recovery from severe acute kidney injury and are able to expand and differentiate in vitro (v0.1)" Open
Background.Acute kidney injury (AKI) is a serious condition associated with chronic kidney disease, dialysis requirement and a high risk of death.However, there are specialized repair mechanisms for the nephron, and migrated committed prog…
View article: Peer Review #2 of "Tubular epithelial progenitors are excreted in urine during recovery from severe acute kidney injury and are able to expand and differentiate in vitro (v0.2)"
Peer Review #2 of "Tubular epithelial progenitors are excreted in urine during recovery from severe acute kidney injury and are able to expand and differentiate in vitro (v0.2)" Open
Background.Acute kidney injury (AKI) is a serious condition associated with chronic kidney disease, dialysis requirement and a high risk of death.However, there are specialized repair mechanisms for the nephron, and migrated committed prog…
View article: Tubular epithelial progenitors are excreted in urine during recovery from severe acute kidney injury and are able to expand and differentiate <i>in vitro</i>
Tubular epithelial progenitors are excreted in urine during recovery from severe acute kidney injury and are able to expand and differentiate <i>in vitro</i> Open
Background Acute kidney injury (AKI) is a serious condition associated with chronic kidney disease, dialysis requirement and a high risk of death. However, there are specialized repair mechanisms for the nephron, and migrated committed pro…
View article: Peer Review #2 of "Tubular epithelial progenitors are excreted in urine during recovery from severe acute kidney injury and are able to expand and differentiate in vitro (v0.1)"
Peer Review #2 of "Tubular epithelial progenitors are excreted in urine during recovery from severe acute kidney injury and are able to expand and differentiate in vitro (v0.1)" Open
Background.Acute kidney injury (AKI) is a serious condition associated with chronic kidney disease, dialysis requirement and a high risk of death.However, there are specialized repair mechanisms for the nephron, and migrated committed prog…
View article: Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual
Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual Open
View article: If It Works, Don’t Touch It? A Cell-Based Approach to Studying 2-[18F]FDG Metabolism
If It Works, Don’t Touch It? A Cell-Based Approach to Studying 2-[18F]FDG Metabolism Open
The glucose derivative 2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG) is still the most used radiotracer for positron emission tomography, as it visualizes glucose utilization and energy demand. In general, 2-[18F]FDG is said to be trapped i…
View article: Particle-number conservation, causality and linear response in biomedical imaging
Particle-number conservation, causality and linear response in biomedical imaging Open
Employing the continuity equation for the tracer density and the methods of linear response theory, we develop efficient mathematical tools for the analysis of dynamically taken positron emission tomography (PET) data. Our approach is quit…
View article: Dynamic 18F-FDG PET imaging of liver lesions: evaluation of a two-tissue compartment model with dual blood input function
Dynamic 18F-FDG PET imaging of liver lesions: evaluation of a two-tissue compartment model with dual blood input function Open
View article: Cytomegalovirus in urinary sediment in patients with acute kidney injury
Cytomegalovirus in urinary sediment in patients with acute kidney injury Open
Background Immunosuppression in solid organ transplantation is associated with frequent infections. Renal allograft recipients are susceptible to opportunistic infections and can acquire human cytomegalovirus (HCMV) infections even within …
View article: A methodological investigation of healthy tissue, hepatocellular carcinoma, and other lesions with dynamic 68Ga-FAPI-04 PET/CT imaging
A methodological investigation of healthy tissue, hepatocellular carcinoma, and other lesions with dynamic 68Ga-FAPI-04 PET/CT imaging Open
View article: A Methodological Investigation of Healthy Tissue, Hepatocellular Carcinoma and other Lesions with Dynamic 68Ga-FAPI-04 PET/CT Imaging
A Methodological Investigation of Healthy Tissue, Hepatocellular Carcinoma and other Lesions with Dynamic 68Ga-FAPI-04 PET/CT Imaging Open
Background: The study aimed to establish a 68 Ga-FAPI-04 kinetic model in hepatic lesions, to determine the potential role of kinetic parameters in the differentiation of hepatocellular carcinoma (HCC) from non-HCC lesions. Material and Me…
View article: Dynamic 2-deoxy-2[18F] fluoro-D-glucose PET/MRI in human renal allotransplant patients undergoing acute kidney injury
Dynamic 2-deoxy-2[18F] fluoro-D-glucose PET/MRI in human renal allotransplant patients undergoing acute kidney injury Open
View article: A novel mathematical approach to estimate the hepatic, cerebral and renal blood flow from dynamic nuclear imaging studies independently of the used radio tracer
A novel mathematical approach to estimate the hepatic, cerebral and renal blood flow from dynamic nuclear imaging studies independently of the used radio tracer Open
Background The blood flow (BF) is a critical determinant of organ functionality. Its assessment in the course of routine nuclear medicine examinations, including planar scintigraphy and positron emission tomography (PET), can be relevant f…
View article: Comparison of different kinetic models for dynamic 68Ga-FAPI-04 PET/CT imaging of hepatocellular carcinoma with various, also dual-blood input function
Comparison of different kinetic models for dynamic 68Ga-FAPI-04 PET/CT imaging of hepatocellular carcinoma with various, also dual-blood input function Open
Aim: The aim of the study is to establish a 68 Ga-FAPI-04 dynamic model in hepatic lesions, to determine the potential role of kinetic parameters in the differentiation of hepatocellular carcinoma (HCC) from non-HCC lesions. Methods: 68 Ga…
View article: Response evaluation of SGLT2 inhibitor therapy in patients with type 2 diabetes mellitus using <sup>18</sup>F-FDG PET/MRI
Response evaluation of SGLT2 inhibitor therapy in patients with type 2 diabetes mellitus using <sup>18</sup>F-FDG PET/MRI Open
Introduction Inhibitors of sodium-glucose linked transporter-2 (SGLT2i) are enhancing glucose excretion in the proximal renal tubules, and thus are increasingly used to lower blood glucose levels in patients with type 2 diabetes mellitus (…
View article: Determinants of the intercept and slope of glomerular filtration rate in recipients of a live donor kidney transplant
Determinants of the intercept and slope of glomerular filtration rate in recipients of a live donor kidney transplant Open
Summary Background Donor kidney function is considered a critical determinant of allograft survival after live donor (LD) kidney transplantation, but its independent impact on the evolution of graft function is less well defined. The objec…