Barbara Pacchetti
YOU?
Author Swipe
View article: Effect of Cannabidiol on Human Peripheral Blood Mononuclear Cells and CD4+ T Cells
Effect of Cannabidiol on Human Peripheral Blood Mononuclear Cells and CD4+ T Cells Open
Cannabidiol (CBD), the main non-psychoactive component of Cannabis sativa L., is widely used in therapy for the treatment of different diseases and as an adjuvant drug. Our aim was to assess the effects of CBD on proinflammatory cytokine p…
View article: The Endocannabinoid Analgesic Entourage Effect: Investigations in Cultured DRG Neurons
The Endocannabinoid Analgesic Entourage Effect: Investigations in Cultured DRG Neurons Open
2-AG, 2-LG and 2-PG significantly delayed TRPV1 signalling in the majority of capsaicin-sensitive DRG neurons, that was markedly increased following combined application. Further studies of these endocannabinoids are required to identify t…
View article: Cannabinoid Conference 2022
Cannabinoid Conference 2022 Open
Introduction: Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive and lethal malignancy. Surgical resection followed by adjuvant chemotherapy is the main therapeutic strategy, but it is less effective in high-grade patients, so new th…
View article: Single and Repeated Exposure to Cannabidiol Differently Modulate BDNF Expression and Signaling in the Cortico-Striatal Brain Network
Single and Repeated Exposure to Cannabidiol Differently Modulate BDNF Expression and Signaling in the Cortico-Striatal Brain Network Open
Cannabidiol (CBD) is a phytocannabinoid contained in the Cannabis sativa plant, devoid of psychotomimetic effects but with a broad-spectrum pharmacological activity. Because of its pharmacological profile and its ability to counteract the …
View article: Real World Evidence in Medical Cannabis Research
Real World Evidence in Medical Cannabis Research Open
Background Whilst access to cannabis-based medicinal products (CBMPs) has increased globally subject to relaxation of scheduling laws globally, one of the main barriers to appropriate patient access remains a paucity of high-quality eviden…
View article: Dose-Related Inhibition of Capsaicin Responses by Cannabinoids CBG, CBD, THC and their Combination in Cultured Sensory Neurons
Dose-Related Inhibition of Capsaicin Responses by Cannabinoids CBG, CBD, THC and their Combination in Cultured Sensory Neurons Open
CBG, CBD and THC demonstrated potent dose-related inhibition of capsaicin responses in DRG neurons when applied individually in vitro, and enhanced when applied in combination, being most effective at 90 μM. Thus, efficacy and tolerability…
View article: The Effect of Cannabis-Based Medicine in the Treatment of Cachexia: A Systematic Review and Meta-Analysis
The Effect of Cannabis-Based Medicine in the Treatment of Cachexia: A Systematic Review and Meta-Analysis Open
Background: Cachexia is a prevalent condition associated with underlying chronic disease. Wasting of skeletal muscle and adipose tissue loss in cachectic patients is associated with higher rates of disability, reduced quality of life (QoL)…
View article: Cannabis-Based Medicines and Pain: A Review of Potential Synergistic and Entourage Effects
Cannabis-Based Medicines and Pain: A Review of Potential Synergistic and Entourage Effects Open
The recent legalization of medicinal cannabis in several jurisdictions has spurred the development of therapeutic formulations for chronic pain. Unlike pure delta-9-tetrahydrocannabinol (THC), full-spectrum products contain naturally occur…
View article: <p>CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons</p>
CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons Open
CBD at low doses corresponding to plasma concentrations observed physiologically inhibits or desensitizes neuronal TRPV1 signalling by inhibiting the adenylyl cyclase - cAMP pathway, which is essential for maintaining TRPV1 phosphorylation…
View article: CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons
CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons Open
Uma Anand,1 Ben Jones,2 Yuri Korchev,3 Stephen R Bloom,2 Barbara Pacchetti,4 Praveen Anand,5 Mikael Hans Sodergren1 1Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London W12 ONN, UK; 2Department of Metabo…
View article: Cannabidiol for Viral Diseases: Hype or Hope?
Cannabidiol for Viral Diseases: Hype or Hope? Open
Background: The possibility of cannabidiol (CBD) to be used as an antiviral or to treat viral diseases has received limited attention so far, despite the growing number of claims that CBD could be used for the treatment of viral infection-…
View article: A Comprehensive Patient and Public Involvement Program Evaluating Perception of Cannabis-Derived Medicinal Products in the Treatment of Acute Postoperative Pain, Nausea, and Vomiting Using a Qualitative Thematic Framework
A Comprehensive Patient and Public Involvement Program Evaluating Perception of Cannabis-Derived Medicinal Products in the Treatment of Acute Postoperative Pain, Nausea, and Vomiting Using a Qualitative Thematic Framework Open
Introduction: Cannabis-derived medicinal products (CDMPs) have antiemetic properties and in combination with opioids have synergistic analgesic effects in part signaling through the delta and kappa opioid receptors. The objective of this p…
View article: <scp><i>Cannabis sativa</i></scp> L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury
<span><i>Cannabis sativa</i></span> L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury Open
Skin inflammatory diseases result from complex events that include dysregulation and abnormal expression of inflammatory mediators or their receptors in skin cells. The present study investigates the potential effect of a Cannabis sativa L…
View article: Comparison of Two<i>Ginkgo biloba</i>L. Extracts on Oxidative Stress and Inflammation Markers in Human Endothelial Cells
Comparison of Two<i>Ginkgo biloba</i>L. Extracts on Oxidative Stress and Inflammation Markers in Human Endothelial Cells Open
Atherosclerosis is characterized by interaction between immune and vascular endothelial cells which is mediated by adhesion molecules occurring on the surface of the vascular endothelium leading to massive release of proinflammatory mediat…
View article: A Novel Standardized Cannabis sativa L. Extract and Its Constituent Cannabidiol Inhibit Human Polymorphonuclear Leukocyte Functions
A Novel Standardized Cannabis sativa L. Extract and Its Constituent Cannabidiol Inhibit Human Polymorphonuclear Leukocyte Functions Open
Cannabis and cannabinoids offer significant therapeutic benefits for a wide scope of pathological conditions. Among them, the clinical issues rooted in inflammation stand out, nonetheless, the underlying mechanisms are not yet plainly unde…
View article: Improved solubility and increased biological activity of NeoSol™RCL40, a novel Red Clover Isoflavone Aglycones extract preparation
Improved solubility and increased biological activity of NeoSol™RCL40, a novel Red Clover Isoflavone Aglycones extract preparation Open
Red clover (Trifolium pratense L., Fabaceae; RCL), a perennial plant rich in isoflavones, is a natural alternative for menopausal symptoms, as well as antiaging and antioxidant. Isoflavone preparations usually contain aglycones and β-glyco…
View article: Selective synthesis of methyl dithienyl-glycolates
Selective synthesis of methyl dithienyl-glycolates Open
An efficient selective synthesis of methyl dithienyl-glycolates has been developed. The interest of this two steps protocol resides in the possibility of synthesized either methyl 2,2-dithienyl glycolate – the target intermediate for the p…
View article: 7-Hydroxymatairesinol improves body weight, fat and sugar metabolism in C57BJ/6 mice on a high-fat diet
7-Hydroxymatairesinol improves body weight, fat and sugar metabolism in C57BJ/6 mice on a high-fat diet Open
7-Hydroxymatairesinol (7-HMR) is a plant lignan abundant in various concentrations in plant foods. The objective of this study was to test HMRLignan™, a purified form of 7-HMR, and the corresponding Picea abies extract (total extract P. ab…