Barbara Nicol
YOU?
Author Swipe
View article: Single-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells
Single-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells Open
Accurate specification of female and male germ cells during embryonic development is critical for sexual reproduction. Primordial germ cells (PGCs) are the bipotential precursors of mature gametes that commit to an oogenic or spermatogenic…
View article: Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells
Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells Open
Accurate specification of female and male germ cells during embryonic development is critical for sexual reproduction. Primordial germ cells (PGCs) are the bipotential precursors of mature gametes that commit to an oogenic or spermatogenic…
View article: Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells
Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells Open
Accurate specification of female and male germ cells during embryonic development is critical for sexual reproduction. Primordial germ cells (PGCs) are the bipotential precursors of mature gametes that commit to an oogenic or spermatogenic…
View article: Progesterone receptor mediates ovulatory transcription through RUNX transcription factor interactions and chromatin remodelling
Progesterone receptor mediates ovulatory transcription through RUNX transcription factor interactions and chromatin remodelling Open
Progesterone receptor (PGR) plays diverse roles in reproductive tissues and thus coordinates mammalian fertility. In the ovary, rapid acute induction of PGR is the key determinant of ovulation through transcriptional control of a unique se…
View article: Loss of Runx1 Induces Granulosa Cell Defects and Development of Ovarian Tumors in the Mouse
Loss of Runx1 Induces Granulosa Cell Defects and Development of Ovarian Tumors in the Mouse Open
Genetic alterations of the RUNX1 gene are associated with a variety of malignancies, including female-related cancers. The role of RUNX1 as either a tumor suppressor gene or an oncogene is tissue-dependent and varies based on the cancer ty…
View article: Becoming female: Ovarian differentiation from an evolutionary perspective
Becoming female: Ovarian differentiation from an evolutionary perspective Open
Differentiation of the bipotential gonadal primordium into ovaries and testes is a common process among vertebrate species. While vertebrate ovaries eventually share the same functions of producing oocytes and estrogens, ovarian differenti…
View article: Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin B
Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin B Open
Fate determination and maintenance of fetal testes in most mammals occur cell autonomously as a result of the action of key transcription factors in Sertoli cells. However, the cases of freemartin, where an XX twin develops testis structur…
View article: Constitutive expression of Steroidogenic factor‐1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice
Constitutive expression of Steroidogenic factor‐1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice Open
Steroid hormones regulate various aspects of physiology, from reproductive functions to metabolic homeostasis. Steroidogenic factor‐1 (NR5A1) plays a central role in the development of steroidogenic tissues and their ability to produce ste…
View article: Progesterone receptor-A isoform interaction with RUNX transcription factors controls chromatin remodelling at promoters during ovulation
Progesterone receptor-A isoform interaction with RUNX transcription factors controls chromatin remodelling at promoters during ovulation Open
Summary Progesterone receptor (PGR) plays diverse roles in reproductive tissues and thus coordinates mammalian fertility. In the ovary, acutely induced PGR is the key determinant of ovulation through transcriptional control of a unique set…
View article: Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice
Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice Open
Development and functions of the ovary rely on appropriate signaling and communication between various ovarian cell types. FOXL2, a transcription factor that plays a key role at different stages of ovarian development, is associated with p…
View article: Increased FOXL2 expression alters uterine structures and functions†
Increased FOXL2 expression alters uterine structures and functions† Open
The transcription factor forkhead box L2 (FOXL2) regulates sex differentiation and reproductive function. Elevated levels of this transcription factor have been observed in the diseases of the uterus, such as endometriosis. However, the im…
View article: In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice
In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice Open
In utero exposure to arsenite (iAs) is known to increase disease risks later in life. We investigated the effect of in utero exposure to iAs in the drinking water on metabolic and reproductive parameters in male mouse offspring at postnata…
View article: Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of <i>Irx3</i> and <i>Irx5</i> in developing mouse gonads
Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of <i>Irx3</i> and <i>Irx5</i> in developing mouse gonads Open
Members of the Iroquois B (IrxB) homeodomain cluster genes, specifically Irx3 and Irx5, are crucial for heart, limb and bone development. Recently, we reported their importance for oocyte and follicle survival within the developing ovary. …
View article: RUNX1 safeguards the identity of the fetal ovary through an interplay with FOXL2
RUNX1 safeguards the identity of the fetal ovary through an interplay with FOXL2 Open
Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian granulosa cells or testicular Sertoli cells. This process of fate specification hinges on a balance of transcriptional control. …
View article: The unusual rainbow trout sex determination gene hijacked the canonical vertebrate gonadal differentiation pathway
The unusual rainbow trout sex determination gene hijacked the canonical vertebrate gonadal differentiation pathway Open
Significance Sex determination is one of the most fundamental but also extraordinary plastic processes in nature. Many different master sex-determining genes have been characterized in vertebrates, and most of them are known to fulfill ess…
View article: Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads
Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads Open
The identity of the gonads is determined by which fate, ovarian granulosa cell or testicular Sertoli cell, the bipotential somatic cell precursors choose to follow. In most vertebrates, the conserved transcription factor FOXL2 contributes …
View article: The bizarre master sex determinant of salmonids triggers its action by directly hijacking the conserved gonadal differentiation pathway
The bizarre master sex determinant of salmonids triggers its action by directly hijacking the conserved gonadal differentiation pathway Open
The bizarre master sex determinant of salmonids triggers its action by directly hijacking the conserved gonadal differentiation pathway. 11. International Symposium on Reproductive Physiology of Fish