Barbara Pavan
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View article: Nasal Administration of a Nanoemulsion Based on Methyl Ferulate and Eugenol Encapsulated in Chitosan Oleate: Uptake Studies in the Central Nervous System
Nasal Administration of a Nanoemulsion Based on Methyl Ferulate and Eugenol Encapsulated in Chitosan Oleate: Uptake Studies in the Central Nervous System Open
Background/Objectives: The phytochemicals ferulic acid (Fer) and eugenol display neuroprotective effects for their anti-oxidative properties; moreover, eugenol can induce dopamine (DA) release from dopaminergic neuronal cells. However, poo…
View article: In Vitro Studies to Evaluate the Intestinal Permeation of an Ursodeoxycholic Acid-Conjugated Oligonucleotide for Duchenne Muscular Dystrophy Treatment
In Vitro Studies to Evaluate the Intestinal Permeation of an Ursodeoxycholic Acid-Conjugated Oligonucleotide for Duchenne Muscular Dystrophy Treatment Open
Delivery represents a major hurdle to the clinical advancement of oligonucleotide therapeutics for the treatment of disorders such as Duchenne muscular dystrophy (DMD). In this preliminary study, we explored the ability of 2′-O-methyl-phos…
View article: Chlorogenic acid permeation across intestinal cell monolayers: Influence by circadian rhythms in the presence of other natural polyphenols and by dopaminergic neuronal-like cells
Chlorogenic acid permeation across intestinal cell monolayers: Influence by circadian rhythms in the presence of other natural polyphenols and by dopaminergic neuronal-like cells Open
Poor oral bioavailability limits chlorogenic acid (CGA) benefits on the gut-brain axis. In this study we demonstrate the existence of an active circadian-dependent efflux for the CGA intestinal permeation, leading to greater bioavailabilit…
View article: Characterization and Hydrolysis Studies of a Prodrug Obtained as Ester Conjugate of Geraniol and Ferulic Acid by Enzymatic Way
Characterization and Hydrolysis Studies of a Prodrug Obtained as Ester Conjugate of Geraniol and Ferulic Acid by Enzymatic Way Open
Ferulic acid (Fer) and geraniol (Ger) are natural compounds whose antioxidant and anti-inflammatory activity confer beneficial properties, such as antibacterial, anticancer, and neuroprotective effects. However, the short half-lives of the…
View article: Theruptor novo: wound dressing for diabetic foot ulcer
Theruptor novo: wound dressing for diabetic foot ulcer Open
One of the main risk factor affecting the normal wound healing process of is diabetes. India being the capital for diabetes, has a prevalence of 9.6% with 74 million patients living with diabetes and is expected to be 124 million by 2045. …
View article: Theruptor Novo dressing for an infected diabetic foot ulcer: a case study
Theruptor Novo dressing for an infected diabetic foot ulcer: a case study Open
In diabetes mellitus (DM) patients with peripheral neuropathy, the diabetic foot infection (DFI) often begins with a small wound that patients may not easily detect and then progresses to a more complex wound. Diabetic foot ulcer (DFU) is …
View article: Heterogeneous patterning of blood-brain barrier and adaptive myelination as renewing key in gray and white matter
Heterogeneous patterning of blood-brain barrier and adaptive myelination as renewing key in gray and white matter Open
Development and homeostasis of the brain are enabled through the precise control of the cell microenvironment by the blood-brain
\nbarrier (BBB), which interfaces between the brain parenchyma and the lumen of blood microvessels, and by the…
View article: Conjugation, Prodrug, and Co-Administration Strategies in Support of Nanotechnologies to Improve the Therapeutic Efficacy of Phytochemicals in the Central Nervous System
Conjugation, Prodrug, and Co-Administration Strategies in Support of Nanotechnologies to Improve the Therapeutic Efficacy of Phytochemicals in the Central Nervous System Open
Phytochemicals, produced as secondary plant metabolites, have shown interesting potential therapeutic activities against neurodegenerative diseases and cancer. Unfortunately, poor bioavailability and rapid metabolic processes compromise th…
View article: Pharmacokinetic and Permeation Studies in Rat Brain of Natural Compounds Led to Investigate Eugenol as Direct Activator of Dopamine Release in PC12 Cells
Pharmacokinetic and Permeation Studies in Rat Brain of Natural Compounds Led to Investigate Eugenol as Direct Activator of Dopamine Release in PC12 Cells Open
Eugenol, cinnamaldehyde and D-limonene, the main components of natural essential oils, are endowed with antioxidant and anti-inflammatory properties which allow them to induce beneficial effects on intestinal, cardiac and neuronal levels. …
View article: Effects of Microencapsulated Ferulic Acid or Its Prodrug Methyl Ferulate on Neuroinflammation Induced by Muramyl Dipeptide
Effects of Microencapsulated Ferulic Acid or Its Prodrug Methyl Ferulate on Neuroinflammation Induced by Muramyl Dipeptide Open
Ferulic acid (Fer) is known for its antioxidant and anti-inflammatory activities, which are possibly useful against neurodegenerative diseases. Despite the ability of Fer to permeate the brain, its fast elimination from the body does not a…
View article: Cocrystals of Nitrofurantoin: How Coformers Can Modify Its Solubility and Permeability Across Intestinal Cell Monolayers
Cocrystals of Nitrofurantoin: How Coformers Can Modify Its Solubility and Permeability Across Intestinal Cell Monolayers Open
Solubility and permeability of nitrofurantoin (NITRO) were compared with those of its cocrystals containing isoniazid (ISO), bipyridyl (BIP), or phenanthroline (PHE) as coformers, and their parent mixtures. NITRO dissolution profiles were …
View article: CCDC 1005832: Experimental Crystal Structure Determination
CCDC 1005832: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1005833: Experimental Crystal Structure Determination
CCDC 1005833: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1005834: Experimental Crystal Structure Determination
CCDC 1005834: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1005835: Experimental Crystal Structure Determination
CCDC 1005835: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Evaluation of the In Vitro Biocompatibility of PEDOT:Nafion Coatings
Evaluation of the In Vitro Biocompatibility of PEDOT:Nafion Coatings Open
Poly(3,4-ethylenedioxythiophene)-Nafion (PEDOT:Nafion) is emerging as a promising alternative to PEDOT-polystyrene sulfonate (PEDOT:PSS) in organic bioelectronics. However, the biocompatibility of PEDOT:Nafion has not been investigated to …
View article: Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?
Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives? Open
Cyclodextrins (CDs) are oligosaccharides widely used in the pharmaceutical field. In this review, a detailed examination of the literature of the last two decades has been made to understand the role of CDs in nasal drug delivery systems. …
View article: Targeting Systems to the Brain Obtained by Merging Prodrugs, Nanoparticles, and Nasal Administration
Targeting Systems to the Brain Obtained by Merging Prodrugs, Nanoparticles, and Nasal Administration Open
About 40 years ago the lipidization of hydrophilic drugs was proposed to induce their brain targeting by transforming them into lipophilic prodrugs. Unfortunately, lipidization often transforms a hydrophilic neuroactive agent into an activ…
View article: Polymeric nanomicelles based on inulin D α-tocopherol succinate for the treatment of diabetic retinopathy
Polymeric nanomicelles based on inulin D α-tocopherol succinate for the treatment of diabetic retinopathy Open
There is a great demand for efficient ocular dosage forms for the treatment of diabetic retinopathy. Nanomicelles named INVITE C, consisting in amphiphilic inulin-D-α-tocopherol succinate bioconjugates (INVITE) and loaded with the antioxid…