Barbara Saccà
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View article: Coupling DNA Origami Filament Growth to an Autocatalytic Production of Fuel
Coupling DNA Origami Filament Growth to an Autocatalytic Production of Fuel Open
In this study, the hierarchical assembly of DNA origami filaments (DOF) initiated by an autocatalytic DNA reaction network (DRN) is investigated. The so‐formed filaments are subsequently disassembled by toehold‐mediated strand displacement…
View article: DNA-based AND logic gate as a molecular precision tool: selective recognition of protein pairs in lipid nanodiscs and subsequent binding of gold nanorods
DNA-based AND logic gate as a molecular precision tool: selective recognition of protein pairs in lipid nanodiscs and subsequent binding of gold nanorods Open
The specificity of target recognition is paramount in fields such as cellular biology, diagnostics, and therapy. Traditional antibody-based methods focus on recognizing single antigens; however, the next level of specificity involves targe…
View article: Modular DNA origami compartments for the engineering of a protein unfolding and degradation pathway
Modular DNA origami compartments for the engineering of a protein unfolding and degradation pathway Open
Within the cell, chemical reactions are often confined and organized through a modular architecture. This facilitates the targeted localization of molecular species and their efficient translocation to subsequent sites. Here, we present a …
View article: Data from Endogenous γ-H2AX-ATM-Chk2 Checkpoint Activation in Bloom's Syndrome Helicase–Deficient Cells Is Related to DNA Replication Arrested Forks
Data from Endogenous γ-H2AX-ATM-Chk2 Checkpoint Activation in Bloom's Syndrome Helicase–Deficient Cells Is Related to DNA Replication Arrested Forks Open
The Bloom syndrome helicase (BLM) is critical for genomic stability. A defect in BLM activity results in the cancer-predisposing Bloom syndrome (BS). Here, we report that BLM-deficient cell lines and primary fibroblasts display an endogeno…
View article: Supplementary Figure S1 from Endogenous γ-H2AX-ATM-Chk2 Checkpoint Activation in Bloom's Syndrome Helicase–Deficient Cells Is Related to DNA Replication Arrested Forks
Supplementary Figure S1 from Endogenous γ-H2AX-ATM-Chk2 Checkpoint Activation in Bloom's Syndrome Helicase–Deficient Cells Is Related to DNA Replication Arrested Forks Open
Supplementary Figure S1 from Endogenous γ-H2AX-ATM-Chk2 Checkpoint Activation in Bloom's Syndrome Helicase–Deficient Cells Is Related to DNA Replication Arrested Forks
View article: Supplementary Figure S1 from Endogenous γ-H2AX-ATM-Chk2 Checkpoint Activation in Bloom's Syndrome Helicase–Deficient Cells Is Related to DNA Replication Arrested Forks
Supplementary Figure S1 from Endogenous γ-H2AX-ATM-Chk2 Checkpoint Activation in Bloom's Syndrome Helicase–Deficient Cells Is Related to DNA Replication Arrested Forks Open
Supplementary Figure S1 from Endogenous γ-H2AX-ATM-Chk2 Checkpoint Activation in Bloom's Syndrome Helicase–Deficient Cells Is Related to DNA Replication Arrested Forks
View article: Data from Endogenous γ-H2AX-ATM-Chk2 Checkpoint Activation in Bloom's Syndrome Helicase–Deficient Cells Is Related to DNA Replication Arrested Forks
Data from Endogenous γ-H2AX-ATM-Chk2 Checkpoint Activation in Bloom's Syndrome Helicase–Deficient Cells Is Related to DNA Replication Arrested Forks Open
The Bloom syndrome helicase (BLM) is critical for genomic stability. A defect in BLM activity results in the cancer-predisposing Bloom syndrome (BS). Here, we report that BLM-deficient cell lines and primary fibroblasts display an endogeno…
View article: Sequence-dependent folding of monolayered DNA origami domains
Sequence-dependent folding of monolayered DNA origami domains Open
The self-assembly of small DNA origami domains is guided by the topology- and sequence-dependent properties of the nucleation sites.
View article: Growth Rate and Thermal Properties of DNA Origami Filaments
Growth Rate and Thermal Properties of DNA Origami Filaments Open
Synthetic DNA filaments exploit the programmability of the individual units and their predictable self-association to mimic the structural and dynamic features of natural protein filaments. Among them, DNA origami filamentous structures ar…
View article: Design, Mechanical Properties, and Dynamics of Synthetic DNA Filaments
Design, Mechanical Properties, and Dynamics of Synthetic DNA Filaments Open
Over the past 40 years, structural and dynamic DNA nanotechnologies have undoubtedly demonstrated to be effective means for organizing matter at the nanoscale and reconfiguring equilibrium structures, in a predictable fashion and with an a…
View article: Self‐Assembled Artificial DNA Nanocompartments and Their Bioapplications
Self‐Assembled Artificial DNA Nanocompartments and Their Bioapplications Open
Compartmentalization is the strategy evolved by nature to control reactions in space and time. The ability to emulate this strategy through synthetic compartmentalization systems has rapidly evolved in the past years, accompanied by an inc…
View article: The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease
The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease Open
DNA nanostructures invert the catalytic response of thrombin to substrates of opposite net charge.
View article: A switchable DNA origami/plasmonic hybrid device with a precisely tuneable DNA-free interparticle gap
A switchable DNA origami/plasmonic hybrid device with a precisely tuneable DNA-free interparticle gap Open
A switchable nanophotonic hybrid device consisting of DNA origami and gold nanospheres with a tuneable and molecule-free dimer hot spot for plasmon-assisted molecular spectroscopy is presented.
View article: Pumilio2 Promotes Growth of Mature Neurons
Pumilio2 Promotes Growth of Mature Neurons Open
RNA-binding proteins (RBPs) are essential regulators controlling both the cellular transcriptome and translatome. These processes enable cellular plasticity, an important prerequisite for growth. Cellular growth is a complex, tightly contr…
View article: DNA Origami Voltage Sensors for Transmembrane Potentials with Single-Molecule Sensitivity
DNA Origami Voltage Sensors for Transmembrane Potentials with Single-Molecule Sensitivity Open
Signal transmission in neurons goes along with changes in the transmembrane potential. To report them, different approaches including optical voltage-sensing dyes and genetically encoded voltage indicators have evolved. Here, we present a …
View article: Site-specific facet protection of gold nanoparticles inside a 3D DNA origami box: a tool for molecular plasmonics
Site-specific facet protection of gold nanoparticles inside a 3D DNA origami box: a tool for molecular plasmonics Open
Pandora's DNA origami box for the site-specific facet protection of gold nanoparticles: a building block for molecular plasmonics.
View article: Insights into the Structure and Energy of DNA Nanoassemblies
Insights into the Structure and Energy of DNA Nanoassemblies Open
Since the pioneering work of Ned Seeman in the early 1980s, the use of the DNA molecule as a construction material experienced a rapid growth and led to the establishment of a new field of science, nowadays called structural DNA nanotechno…
View article: Manipulating Enzymes Properties with DNA Nanostructures
Manipulating Enzymes Properties with DNA Nanostructures Open
Nucleic acids and proteins are two major classes of biopolymers in living systems. Whereas nucleic acids are characterized by robust molecular recognition properties, essential for the reliable storage and transmission of the genetic infor…
View article: Three-Dimensional DNA Origami as Programmable Anchoring Points for Bioreceptors in Fiber Optic Surface Plasmon Resonance Biosensing
Three-Dimensional DNA Origami as Programmable Anchoring Points for Bioreceptors in Fiber Optic Surface Plasmon Resonance Biosensing Open
Many challenges in biosensing originate from the fact that the all-important nanoarchitecture of the biosensor surface, including precise density and orientation of bioreceptors, is not entirely comprehended. Here, we introduced a three-di…