Barbara Szomolay
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View article: Developing interferon-β as a safe in vivo experimental-medicine model of human inflammation
Developing interferon-β as a safe in vivo experimental-medicine model of human inflammation Open
IFN-β is a safe, robust new experimental model of mild inflammation that can be safely used to induce transient changes in systemic inflammation in healthy individuals from 18-75 years. Modulation of diverse immunological processes suggest…
View article: Discrete cytokine signaling networks instruct distinct synovial pathotypes in inflammatory arthritis
Discrete cytokine signaling networks instruct distinct synovial pathotypes in inflammatory arthritis Open
Patients with rheumatoid arthritis (RA) display distinct patterns of synovitis. To define the inflammatory mechanisms driving this heterogeneity, we analyzed the inflamed synovium of wild-type (WT), Il6ra -/- , and Il27ra -/- mice with ant…
View article: 12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation
12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation Open
12/15-lipoxygenase (12/15-LOX, Alox15 ) generates bioactive oxygenated lipids during inflammation, however its homeostatic role(s) in normal healing are unclear. Here, the role of 12/15-LOX in resolving skin wounds was elucidated, focusing…
View article: P112 Cytokine driven disease and epigenetic heterogeneity in rheumatoid arthritis
P112 Cytokine driven disease and epigenetic heterogeneity in rheumatoid arthritis Open
Background/Aims Therapies that target cytokine signals have revolutionised the treatment of immune-mediated inflammatory diseases. However, many patients show an inadequate response to particular drug classes, reflecting the complex and of…
View article: 12/15-Lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation
12/15-Lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation Open
12/15-lipoxygenase (12/15-LOX, Alox15 ) generates bioactive oxygenated lipids during inflammation, however its homeostatic role(s) in normal healing are unclear. Here, the role of 12/15-LOX in resolving skin wounds was elucidated, focusing…
View article: Developing Interferon-β as a safe in-vivo experimental-medicine model of human inflammation
Developing Interferon-β as a safe in-vivo experimental-medicine model of human inflammation Open
Background Inflammation is increasingly implicated in a wide range of neuropsychiatric disorders ranging from depression through age- and infection-related cognitive decline to dementia. Arguably, the most important evidence supporting an …
View article: MHC-related protein 1–restricted recognition of cancer via a semi-invariant TCR-α chain
MHC-related protein 1–restricted recognition of cancer via a semi-invariant TCR-α chain Open
The T cell antigen presentation platform MR1 consists of 6 allomorphs in humans that differ by no more than 5 amino acids. The principal function of this highly conserved molecule involves presenting microbial metabolites to the abundant m…
View article: Over-the-counter antibiotics compromising aminoglycoside activity
Over-the-counter antibiotics compromising aminoglycoside activity Open
Introduction Antimicrobial resistance (AMR) is a global issue that needs addressing. While antibiotic stewardship has improved often by restricting antibiotic use, some antibiotics that are still sold legally over the counter (OTC), notabl…
View article: Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages
Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages Open
View article: STING Orchestrates EV-D68 Replication and Immunometabolism within Viral-Induced Replication Organelles
STING Orchestrates EV-D68 Replication and Immunometabolism within Viral-Induced Replication Organelles Open
Some respiratory viruses, such as Human Rhinovirus, SARS-CoV-2, and Enterovirus D-68 (EV-D68), share the feature of hijacking host lipids in order to generate specialised replication organelles (ROs) with unique lipid compositions to enabl…
View article: HLA A*24:02–restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes
HLA A*24:02–restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes Open
CD8+ T cells destroy insulin-producing pancreatic β cells in type 1 diabetes through HLA class I-restricted presentation of self-antigens. Combinatorial peptide library screening was used to produce a preferred peptide recognition landscap…
View article: Systems Biology in ELIXIR: modelling in the spotlight
Systems Biology in ELIXIR: modelling in the spotlight Open
In this white paper, we describe the founding of a new ELIXIR Community - the Systems Biology Community - and its proposed future contributions to both ELIXIR and the broader community of systems biologists in Europe and worldwide. The Com…
View article: Synergising ELIXIR resources for training in systems biology
Synergising ELIXIR resources for training in systems biology Open
Systems biology (SB) is a new ELIXIR community, that aims to utilise the ELIXIR ecosystem, such as the Training eSupport System (TeSS) and bio.tools, a registry of software tools and data resources for life sciences. One of the main initia…
View article: Analysis of single nuclear chromatin accessibility reveals unique myeloid populations in human pancreatic ductal adenocarcinoma
Analysis of single nuclear chromatin accessibility reveals unique myeloid populations in human pancreatic ductal adenocarcinoma Open
Background A better understanding of the pancreatic ductal adenocarcinoma (PDAC) immune microenvironment is critical to developing new treatments and improving outcomes. Myeloid cells are of particular importance for PDAC progression; howe…
View article: Systems Approaches to Cell Culture-Derived Extracellular Vesicles for Acute Kidney Injury Therapy: Prospects and Challenges
Systems Approaches to Cell Culture-Derived Extracellular Vesicles for Acute Kidney Injury Therapy: Prospects and Challenges Open
Acute kidney injury (AKI) is a heterogeneous syndrome, comprising diverse etiologies of kidney insults that result in high mortality and morbidity if not well managed. Although great efforts have been made to investigate underlying pathoge…
View article: Bifidobacterium affects antitumor efficacy of oncolytic adenovirus in a mouse model of melanoma
Bifidobacterium affects antitumor efficacy of oncolytic adenovirus in a mouse model of melanoma Open
Gut microbiota plays a key role in modulating responses to cancer immunotherapy in melanoma patients. Oncolytic viruses (OVs) represent emerging tools in cancer therapy, inducing a potent immunogenic cancer cell death (ICD) and recruiting …
View article: Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy Open
The T cells of the immune system can target tumors and clear solid cancers following tumor-infiltrating lymphocyte (TIL) therapy. We used combinatorial peptide libraries and a proteomic database to reveal the antigen specificities of persi…
View article: Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to <i>Alu</i>-like Retroelements
Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to <i>Alu</i>-like Retroelements Open
Cytokines that signal via STAT1 and STAT3 transcription factors instruct decisions affecting tissue homeostasis, antimicrobial host defense, and inflammation-induced tissue injury. To understand the coordination of these activities, we app…
View article: Supplementary Data File S1 from Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma
Supplementary Data File S1 from Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma Open
Supplementary Data File S1
View article: Supplementary Data File S1 from Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma
Supplementary Data File S1 from Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma Open
Supplementary Data File S1
View article: Supplementary Tables and Figures from Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma
Supplementary Tables and Figures from Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma Open
Supplementary Tables 1-3 and Figures 1-6
View article: Supplementary Tables and Figures from Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma
Supplementary Tables and Figures from Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma Open
Supplementary Tables 1-3 and Figures 1-6
View article: Data from Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma
Data from Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma Open
Molecular mimicry is one of the leading mechanisms by which infectious agents can induce autoimmunity. Whether a similar mechanism triggers an antitumor immune response is unexplored, and the role of antiviral T cells infiltrating the tumo…
View article: Data from Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma
Data from Viral Molecular Mimicry Influences the Antitumor Immune Response in Murine and Human Melanoma Open
Molecular mimicry is one of the leading mechanisms by which infectious agents can induce autoimmunity. Whether a similar mechanism triggers an antitumor immune response is unexplored, and the role of antiviral T cells infiltrating the tumo…
View article: P130 Transcriptomic analysis of synovitis identifies inhibition of CXCL1 as a mechanism contributing to resolution of inflammatory arthritis under IL-27 control
P130 Transcriptomic analysis of synovitis identifies inhibition of CXCL1 as a mechanism contributing to resolution of inflammatory arthritis under IL-27 control Open
Background/Aims Interleukin-27 (IL-27) regulates adaptive immune responses and is critical for the timely resolution of inflammation to restore tissue homeostasis. Studies have highlighted roles for IL-27 in limiting immune cell effector f…
View article: Systems Biology Approaches for the Improvement of Oncolytic Virus-Based Immunotherapies
Systems Biology Approaches for the Improvement of Oncolytic Virus-Based Immunotherapies Open
Oncolytic virus (OV)-based immunotherapy is mainly dependent on establishing an efficient cell-mediated antitumor immunity. OV-mediated antitumor immunity elicits a renewed antitumor reactivity, stimulating a T-cell response against tumor-…
View article: Systems Biology in ELIXIR: modelling in the spotlight
Systems Biology in ELIXIR: modelling in the spotlight Open
In this white paper, we describe the founding of a new ELIXIR Community - the Systems Biology Community - and its proposed future contributions to both ELIXIR and the broader community of systems biologists in Europe and worldwide. The Com…
View article: Responses of <i>Salmonella</i> biofilms to oxidizing biocides: Evidence of spatial clustering
Responses of <i>Salmonella</i> biofilms to oxidizing biocides: Evidence of spatial clustering Open
The spatial organization of biofilm bacterial communities can be influenced by several factors, including growth conditions and challenge with antimicrobials. Differential survival of clusters of cells within biofilms has been observed. In…
View article: Community-driven ELIXIR activities in single-cell omics
Community-driven ELIXIR activities in single-cell omics Open
Single-cell omics (SCO) has revolutionized the way and the level of resolution by which life science research is conducted, not only impacting our understanding of fundamental cell biology but also providing novel solutions in cutting-edge…
View article: Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to<i>Alu</i>-like retroelements
Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to<i>Alu</i>-like retroelements Open
Cytokines that signal via STAT1 and STAT3 transcription factors instruct decisions affecting tissue homeostasis, anti-microbial host defense, and inflammation-induced tissue injury. To understand the coordination of these activities, we ap…