Explanipedia

Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance (Adv. Therap. 5/2025) Open

Sari Rasheed, Florian Umstätter, Eric Mühlberg, Barbro Beijer, Tobias Hertlein , et al. · 2025

Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance Open

Sari Rasheed, Florian Umstätter, Eric Mühlberg, Barbro Beijer, Tobias Hertlein , et al. · 2025

The benefit that antibiotics confer to the welfare of mankind is threatened by bacterial resistance. Resistance to daptomycin, a cyclic lipopeptide frequently used for the treatment of complicated bacteremia, is a prime example of this ala…

Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics Open

Julia Werner, Florian Umstätter, Manuel Ben Böhmann, Katharina Müller, Barbro Beijer , et al. · 2024

Antibiotic‐resistant enterococci represent a significant global health challenge. Unfortunately, most β‐lactam antibiotics are not applicable for enterococcal infections due to intrinsic resistance. To extend their antimicrobial spectrum, …

Oral Delivery of the Vancomycin Derivative FU002 by a Surface‐Modified Liposomal Nanocarrier Open

Julia Werner, Florian Umstätter, Tobias Hertlein, Eric Mühlberg, Barbro Beijer , et al. · 2024

Oral delivery of peptide therapeutics faces multiple challenges due to their instability in the gastrointestinal tract and low permeation capability. In this study, the aim is to develop a liposomal nanocarrier formulation to enable the or…

Improved pharmacokinetics and enhanced efficacy of the vancomycin derivative FU002 using a liposomal nanocarrier Open

Julia Werner, Florian Umstätter, Tobias Hertlein, Barbro Beijer, Christian Kleist , et al. · 2023

Antibiotic resistance still represents a global health concern which diminishes the pool of effective antibiotics. With the vancomycin derivative FU002, we recently reported a highly potent substance active against Gram-positive bacteria w…

Non-cross-linking advanced glycation end products affect prohormone processing Open

Sebastian Brings, Walter Mier, Barbro Beijer, Elisabeth Kliemank, Stephan Herzig , et al. · 2023

Advanced glycation end products (AGEs) are non-enzymatic post-translational modifications of amino acids and are associated with diabetic complications. One proposed pathomechanism is the impaired processing of AGE-modified proteins or pep…

Refined Chelator Spacer Moieties Ameliorate the Pharmacokinetics of PSMA-617 Open

José Carlos dos Santos, Martin Schäfer, Ulrike Bauder‐Wüst, Barbro Beijer, Matthias Eder , et al. · 2022

Prostate-specific membrane antigen (PSMA) binding tracers are promising agents for the targeting of prostate tumors. To further optimize the clinically established radiopharmaceutical PSMA-617, novel PSMA ligands for prostate cancer endora…

Impact of Linker Modification and PEGylation of Vancomycin Conjugates on Structure-Activity Relationships and Pharmacokinetics Open

Florian Umstätter, Julia Werner, Leah Zerlin, Eric Mühlberg, Christian Kleist , et al. · 2022

As multidrug-resistant bacteria represent a concerning burden, experts insist on the need for a dramatic rethinking on antibiotic use and development in order to avoid a post-antibiotic era. New and rapidly developable strategies for antim…

Corrigendum: Vancomycin Resistance is Overcome by Conjugation of Polycationic Peptides Open

Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg , et al. · 2020

A vancomycin-arginine conjugate that is effective against Gram-negative bacteria, [1] and a D-octaarginine conjugate of vancomycin that eliminates biofilm-associated MRSA in a murine wound infection model, MRSA persister cells, and vancomy…

Berichtigung: Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden Open

Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg , et al. · 2020

Vancomycin-Lipopeptide Conjugates with High Antimicrobial Activity on Vancomycin-Resistant Enterococci Open

Eric Mühlberg, Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen , et al. · 2020

Multidrug-resistant bacteria represent one of the most important health care problems worldwide. While there are numerous drugs available for standard therapy, there are only a few compounds capable of serving as a last resort for severe i…

Graphisches Inhaltsverzeichnis: Angew. Chem. 23/2020 Open

Lena Scherthan, Alan Powell, Volker Schünemann, Carmen Leitner, Marion Schulz , et al. · 2020

The interpretation of the chemical bond in NaBH 3À as a dative bond Na À !BH 3 proposed by Liu et al. is questioned.The dissociation products are Na À and BH 3 but the nature of the bond changes during the bond formation from dative intera…

Innenrücktitelbild: Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden (Angew. Chem. 23/2020) Open

Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg , et al. · 2020

Bakterielle Resistenzen drohen, die Errungenschaften der Antibiotikatherapie zunichte zu machen. Wie P. Uhl et al. in ihrer Zuschrift auf S. 8908 erläutern, konnte am Klinikum Heidelberg mit Peptid-Konjugaten eine tausendfache Aktivitätsst…

Inside Back Cover: Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides (Angew. Chem. Int. Ed. 23/2020) Open

Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg , et al. · 2020

Bacterial resistance threatens to destroy the achievements of antibiotic therapy. As P. Uhl and co-workers report in their Communication on page 8823, a 1000-fold increase in the activity of the reserve antibiotic vancomycin was achieved b…

Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden Open

Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg , et al. · 2020

Die zunehmende Prävalenz von Resistenzen bei Bakterien gegen Glykopeptid‐Antibiotika macht auch vor Vancomycin nicht halt. Um die ursprünglich hohe Effektivität gegen diese resistenten Bakterien wieder zu erzielen, wurden hier polykationis…

Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides Open

Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg , et al. · 2020

Multidrug‐resistant bacteria represent one of the biggest challenges facing modern medicine. The increasing prevalence of glycopeptide resistance compromises the efficacy of vancomycin, for a long time considered as the last resort for the…

Development of Novel PSMA Ligands for Imaging and Therapy with Copper Isotopes Open

José Carlos dos Santos, Barbro Beijer, Ulrike Bauder‐Wüst, Martin Schäfer, Karin Leotta , et al. · 2019

Prostate-specific membrane antigen (PSMA)-binding tracers have been shown to be promising agents for the specific targeting of prostate tumors. On labeling with the short-lived isotopes ¹⁸F and ⁶⁸Ga, excellent molecul…

A scavenger peptide prevents methylglyoxal induced pain in mice Open

Sebastian Brings, Thomas Fleming, Svenja De Buhr, Barbro Beijer, Thomas Lindner , et al. · 2016

The reactive metabolite methylglyoxal (MG) has been identified as mediator of pain. Scavenging of free MG and the prevention of MG-derived post-translational modifications may provide a useful therapeutic treatment. An arginine-rich, fatty…

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