Barry Fuller
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View article: Cryopreservation of implantable human skeletal muscle−derived cell-microcarrier combinations for use in clinical regenerative medicine
Cryopreservation of implantable human skeletal muscle−derived cell-microcarrier combinations for use in clinical regenerative medicine Open
Overall, these findings pave the way to use cold-chain product supply for future clinical studies with the implantable cell-microcarrier technology.
View article: PERSPECTIVE: Potential impact of the forthcoming european union substances of human origin regulation on the programme of allotransplantation of cryopreserved vascular tissue grafts
PERSPECTIVE: Potential impact of the forthcoming european union substances of human origin regulation on the programme of allotransplantation of cryopreserved vascular tissue grafts Open
The Czech vascular tissue transplantation programme has operated under the conditions set by European Union (EU) directives since 2013. The aim of this analysis was to assess the impact of the new EU regulation on it and to analyse potenti…
View article: Evaluation of a single-use bioartificial liver (BAL) biocartridge consisting of cryopreservable alginate encapsulated liver cell spheroids as a component of HepatiCan™, a novel bioartificial liver device
Evaluation of a single-use bioartificial liver (BAL) biocartridge consisting of cryopreservable alginate encapsulated liver cell spheroids as a component of HepatiCan™, a novel bioartificial liver device Open
Introduction alternative therapies to complement liver transplantation and treat patients with liver failure are not available. In this study, a clinical scale single-use biocartridge was developed for use as part of a novel Bioartificial …
View article: Immune cells in liver regeneration: Current evidence and potential clinical targets
Immune cells in liver regeneration: Current evidence and potential clinical targets Open
The livers' ability to regenerate after injury has attracted the investigation of possible therapeutic targets for liver disease. Cells of the immune system are considered fundamental for the initiation, propagation, and termination of liv…
View article: Inflammatory Monocytes Are Rapidly Recruited to the Post-Ischaemic Liver in Patients Undergoing Liver Transplantation and Cytokines Associated with Their Activation Correlate with Graft Outcomes
Inflammatory Monocytes Are Rapidly Recruited to the Post-Ischaemic Liver in Patients Undergoing Liver Transplantation and Cytokines Associated with Their Activation Correlate with Graft Outcomes Open
Liver ischaemia–reperfusion (IR) injury remains a major cause of morbidity and mortality following liver transplantation and resection. CD4+ T cells have been shown to play a key role in murine models; however, there is currently a lack of…
View article: Inflammatory Monocytes Are Rapidly Recruited to the Post Ischaemic Liver in Patients Undergoing Liver Transplantation and Cytokines Associated with Their Activation Correlate with Graft Outcomes
Inflammatory Monocytes Are Rapidly Recruited to the Post Ischaemic Liver in Patients Undergoing Liver Transplantation and Cytokines Associated with Their Activation Correlate with Graft Outcomes Open
Liver ischaemia-reperfusion (IR) injury remains a major cause of morbidity and mortality following liver transplantation and resection. CD4+ T cells have been shown to play a key role in murine models however there is currently a lack of d…
View article: Cryobiological aspects of upscaling cryopreservation for encapsulated liver cell therapies
Cryobiological aspects of upscaling cryopreservation for encapsulated liver cell therapies Open
For the efficient delivery of a cell therapy a treatment must be provided rapidly, at clinical scale, contain a sufficient active cellular component (biomass), and adhere to a multitude of regulatory requirements. Cryopreservation permits …
View article: The Modern Cryobank as Key Support for Clinical Cell and Tissue Transplantation Programmes
The Modern Cryobank as Key Support for Clinical Cell and Tissue Transplantation Programmes Open
The authors review the essential role of modern cryobanks in the development of cryotechnology before the start of the clinical cell and tissue transplantation programme and in the routine support of these programmes within the legislative…
View article: To the 70th Anniversary of Ukraine’s Membership in UNESCO. UNESCO Chair in Cryobiology: Milestones, Experience, Results, Perspectives
To the 70th Anniversary of Ukraine’s Membership in UNESCO. UNESCO Chair in Cryobiology: Milestones, Experience, Results, Perspectives Open
View article: PERSPECTIVE: The cold chain delivery of organs for transplantation: from research laboratories and individual enthusiasts to pan-global networks in 50 years
PERSPECTIVE: The cold chain delivery of organs for transplantation: from research laboratories and individual enthusiasts to pan-global networks in 50 years Open
It is some 50 years since the first published reports appeared of ex vivo preservation of organs for transplantation. Over the intervening decades, organ preservation strategies have become one essential component of world-wide clinical tr…
View article: Innovation in cryopreservation & cold chain management
Innovation in cryopreservation & cold chain management Open
Successful cryopreservation depends to a large extent on how the cell water compartments respond to ultra-low temperature cooling, which in itself is necessary to inhibit all molecular interactions for long-term biopreservation. Biophysica…
View article: Perspective: The Role of Cryopreservation Techniques in Manufacturing, Transport, and Storage of Car-T Therapy Products
Perspective: The Role of Cryopreservation Techniques in Manufacturing, Transport, and Storage of Car-T Therapy Products Open
Several clinical trials have proved the efficacy and safety of T-cells chimeric antigen receptor (CAR-T cells) in treatment of malignant lymphoma and the first products were registered in the European Union in 2018. The shelf-life of CAR-T…
View article: Liver Ultrasound Histotripsy: Novel Analysis of the Histotripsy Site Cell Constituents with Implications for Histotripsy Application in Cell Transplantation and Cancer Therapy
Liver Ultrasound Histotripsy: Novel Analysis of the Histotripsy Site Cell Constituents with Implications for Histotripsy Application in Cell Transplantation and Cancer Therapy Open
Introduction: Allogenic hepatocyte transplantation is an attractive alternative to whole-organ transplantation, particularly for the treatment of metabolic disorders and acute liver failure. However, the shortage of human donor organs for …
View article: Hypothermic Organ Perfusion in the 2020's: Mixing the Benefits of Low Temperatures and Dynamic Flow Outside The Body
Hypothermic Organ Perfusion in the 2020's: Mixing the Benefits of Low Temperatures and Dynamic Flow Outside The Body Open
The cold chain supply of donor organs for transplantation has been an integral part of the delivery of transplant clinical services over the past five decades. Within the technologies used for this, hypothermic machine perfusion (HMP) was …
View article: Lessons learned from the COVID-19 pandemic about sample access for research in the UK
Lessons learned from the COVID-19 pandemic about sample access for research in the UK Open
Objective Annotated clinical samples taken from patients are a foundation of translational medical research and give mechanistic insight into drug trials. Prior research by the Tissue Directory and Coordination Centre (TDCC) indicated that…
View article: Mitochondrial respiratory chain and Krebs cycle enzyme function in human donor livers subjected to end-ischaemic hypothermic machine perfusion
Mitochondrial respiratory chain and Krebs cycle enzyme function in human donor livers subjected to end-ischaemic hypothermic machine perfusion Open
Introduction Marginal human donor livers are highly susceptible to ischaemia reperfusion injury and mitochondrial dysfunction. Oxygenation during hypothermic machine perfusion (HMP) was proposed to protect the mitochondria but the mechanis…
View article: New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice
New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice Open
View article: P189 Role of high intensity focused ultrasound (HIFU) in treating cancerous lesions of the hepatobiliary system
P189 Role of high intensity focused ultrasound (HIFU) in treating cancerous lesions of the hepatobiliary system Open
Aims High intensity focused ultrasound (HIFU) is an emerging non-invasive, targeted treatment of malignancy. This review aims to explore the efficacy, safety and optimal technical parameters of HIFU to treat cancerous lesions of the hepato…
View article: P190 Proof of concept & novel technique of cell harvest using histotripsy: implications in cell transplantation
P190 Proof of concept & novel technique of cell harvest using histotripsy: implications in cell transplantation Open
Introduction A potential alternative to liver transplantation is allogenic hepatocyte transplantation, particularly for metabolic disorders. However, some significant hurdles mainly concerned shortage of donor organs, low cell yield as wel…
View article: Oocyte Cryopreservation in Emergency Situations: Perspectives and Reality
Oocyte Cryopreservation in Emergency Situations: Perspectives and Reality Open
Increased incidence of global recorded cancer, unforeseen circumstances in assisted reproductive technology, a pandemic situation, and surgical interventions which can cause impairment of the reproductive system all necessitate urgent fert…
View article: Systematic review of the role of high intensity focused ultrasound (HIFU) in treating malignant lesions of the hepatobiliary system
Systematic review of the role of high intensity focused ultrasound (HIFU) in treating malignant lesions of the hepatobiliary system Open
View article: Small-Scale Fluidized Bed Bioreactor for Long-Term Dynamic Culture of 3D Cell Constructs and in vitro Testing
Small-Scale Fluidized Bed Bioreactor for Long-Term Dynamic Culture of 3D Cell Constructs and in vitro Testing Open
With the increasing interest in three-dimensional (3D) cell constructs that better represent native tissues, comes the need to also invest in devices, i.e., bioreactors, that provide a controlled dynamic environment similar to the perfusio…
View article: Increased expression of IGF-1Ec with increasing colonic polyp dysplasia and colorectal cancer
Increased expression of IGF-1Ec with increasing colonic polyp dysplasia and colorectal cancer Open
View article: COVID-19 as a Potential Target for Cryobiology and Cryomedicine
COVID-19 as a Potential Target for Cryobiology and Cryomedicine Open
The review presents data on immune pathogenesis of COVID-19 and approaches to its prevention and treatment. The low effectiveness of antiviral drugs is caused by the ability of SARS-CoV2 virus to change its own structure and functions. Exi…
View article: The Barriers and Motivators to Using Human Tissues for Research: The Views of UK-Based Biomedical Researchers
The Barriers and Motivators to Using Human Tissues for Research: The Views of UK-Based Biomedical Researchers Open
Introduction: The use of human-derived samples is vital to numerous areas of biological and medical research. Despite this, researchers often find or anticipate difficulty in sourcing samples. There are ongoing efforts to inc…
View article: Dimethyl Sulfoxide: A Central Player Since the Dawn of Cryobiology, is Efficacy Balanced by Toxicity?
Dimethyl Sulfoxide: A Central Player Since the Dawn of Cryobiology, is Efficacy Balanced by Toxicity? Open
Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken p…
View article: The extracellular fluid macromolecular composition differentially affects cell-substrate adhesion and cell morphology
The extracellular fluid macromolecular composition differentially affects cell-substrate adhesion and cell morphology Open
Soluble macromolecules present in the tumour microenvironment (TME) alter the physical characteristics of the extracellular fluid and can affect cancer cell behaviour. A fundamental step in cancer progression is the formation of a new vasc…
View article: Stopping the biological clock Merging biology and cryogenics in applied cryobiology
Stopping the biological clock Merging biology and cryogenics in applied cryobiology Open
The ability to stop all cellular activity for a prolonged period of time, yet still be able to deliver functional recovery on demand, is the practical output of the science of cryobiology. This cessation of biological time allows cells to …
View article: Mechano-growth Factor Expression in Colorectal Cancer Investigated With Fluorescent Gold Nanoparticles
Mechano-growth Factor Expression in Colorectal Cancer Investigated With Fluorescent Gold Nanoparticles Open
MGF appears to be overexpressed in colon cancer tissues, offering a potential unique target for imaging and drug delivery in colon cancer.
View article: Top research priorities in liver and gallbladder disorders in the UK
Top research priorities in liver and gallbladder disorders in the UK Open
Objectives There is a mismatch between research questions considered important by patients, carers and healthcare professionals and the research performed in many fields of medicine. The non-alcohol-related liver and gallbladder disorders …