Bart Brouwer
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In Situ Mapping of Pressure-Induced Exciton Traps in Suspended MoS <sub>2</sub> Monolayers Using Fabry–Perot Interference Open
We demonstrate the in situ readout of the spatial profile of suspended MoS2 monolayers hosted on substrates with nanostructured holes. As the profiles are spatially bent, the suspended MoS2 monolayers act as exciton traps with a tunable lu…
Genetically Encoded 3-Aminotyrosine as Catalytic Residue in a Designer Friedel-Crafts Alkylase Open
Genetic incorporation of noncanonical amino acids (ncAAs) harboring catalytic side chains into proteins allows the creation of enzymes able to catalyze reactions that have no equivalent in nature. Here, we present for the first time the us…
Genetically encoded 3-aminotyrosine as catalytic residue in a designer Friedel–Crafts alkylase Open
An evolved designer enzyme featuring genetically encoded 3-aminotyrosine (aY) as catalytic residue promotes highly enantioselective Friedel–Crafts alkylations, is enantiocomplementary to a prior design, and enables whole-cell biocatalysis.
View article: Boron Designer Enzyme with a Hybrid Catalytic Dyad
Boron Designer Enzyme with a Hybrid Catalytic Dyad Open
Genetically encoded noncanonical amino acids can introduce new-to-nature activation modes into enzymes. While these amino acids can act as catalysts on their own due to their inherent chemical properties, interactions with adjacent residue…
Noncanonical Amino Acids: Bringing New-to-Nature Functionalities to Biocatalysis Open
Biocatalysis has become an important component of modern organic chemistry, presenting an efficient and environmentally friendly approach to synthetic transformations. Advances in molecular biology, computational modeling, and protein engi…
Polarization effects in super resolution STED microscopy Open
The invention of the microscope made it possible for people to study the structure of matter below the millimeter scale. Unfortunately the smallest details which can be resolved by conventional techniques, such as confocal microscopy, are …