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View article: Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder
Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder Open
Loss-of-function mutations in AKAP11 (a protein kinase A (PKA)-binding protein) greatly increase the risk of bipolar disorder and schizophrenia. To determine the neurobiological functions of AKAP11, we conduct multi-omic and neurobiologica…
View article: Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution
Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution Open
Dynamic signaling by extracellular and intracellular molecules impacts downstream pathways in a cell-type-specific manner. Fluorescent reporters of such signals are typically optimized to detect fast, relative changes in concentration of t…
View article: Sensitive dLight for imaging broad-spectrum dopamine events across brain regions
Sensitive dLight for imaging broad-spectrum dopamine events across brain regions Open
Dopaminergic neurons modulate movement, motivation, and learning by dynamically regulating dopamine release across distributed neural circuits. However, existing genetically encoded dopamine sensors lack the sensitivity and resolution to c…
View article: Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution
Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution Open
The concentrations of extracellular and intracellular signaling molecules, such as dopamine and cAMP, change over both fast and slow timescales and impact downstream pathways in a cell-type specific manner. Fluorescence sensors currently u…
View article: Hunger modulates exploration through suppression of dopamine signaling in the tail of striatum
Hunger modulates exploration through suppression of dopamine signaling in the tail of striatum Open
Summary Caloric depletion leads to behavioral changes that help an animal find food and restore its homeostatic balance. Hunger increases exploration and risk-taking behavior, allowing an animal to forage for food despite risks; however, t…
View article: Elevated synaptic PKA activity and abnormal striatal dopamine signaling in <i>Akap11</i> mutant mice, a genetic model of schizophrenia and bipolar disorder
Elevated synaptic PKA activity and abnormal striatal dopamine signaling in <i>Akap11</i> mutant mice, a genetic model of schizophrenia and bipolar disorder Open
Loss-of-function mutations in AKAP11 (a protein kinase A (PKA)-binding protein) greatly increase the risk of bipolar disorder and schizophrenia. To determine the neurobiological functions of AKAP11, we conduct multi-omic and neurobiologica…
View article: Real‐Time, In Vivo Measurement of Protein Kinase A Activity in Deep Brain Structures Using Fluorescence Lifetime Photometry (FLiP)
Real‐Time, In Vivo Measurement of Protein Kinase A Activity in Deep Brain Structures Using Fluorescence Lifetime Photometry (FLiP) Open
The biochemical state of neurons, and of cells in general, is regulated by extracellular factors, including neurotransmitters, neuromodulators, and growth hormones. Interactions of an animal with its environment trigger neuromodulator rele…
View article: Cue and Reward Evoked Dopamine Activity Is Necessary for Maintaining Learned Pavlovian Associations
Cue and Reward Evoked Dopamine Activity Is Necessary for Maintaining Learned Pavlovian Associations Open
Associating natural rewards with predictive environmental cues is crucial for survival. Dopamine (DA) neurons of the ventral tegmental area (VTA) are thought to play a crucial role in this process by encoding reward prediction errors (RPEs…
View article: Cell-type specific asynchronous modulation of PKA by dopamine during reward based learning
Cell-type specific asynchronous modulation of PKA by dopamine during reward based learning Open
Summary Canonical reinforcement learning models postulate that dopamine neurons encode reward prediction error (RPE) and provide a teaching signal to striatal spiny projection neurons (SPNs) in the form of dopamine (DA) release. DA is thou…
View article: Monitoring Behaviorally Induced Biochemical Changes Using Fluorescence Lifetime Photometry
Monitoring Behaviorally Induced Biochemical Changes Using Fluorescence Lifetime Photometry Open
All cells respond to extracellular signals by altering their intracellular biochemical state. In neurons, such signaling regulates many aspects of cell and synapse biology and induces changes that are thought to be important for nervous sy…