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View article: Dutch guideline for the prevention and control of multidrug-resistant organisms in the hospital setting, 2024 update
Dutch guideline for the prevention and control of multidrug-resistant organisms in the hospital setting, 2024 update Open
The emergence of multidrug-resistant organisms (MDROs) represents a significant challenge for global healthcare systems. The Netherlands maintains one of the lowest antimicrobial resistance rates in the world, attributed to prudent antibio…
View article: Developing infection prevention and control guidelines for healthcare professionals in the Netherlands: an evaluation of the process
Developing infection prevention and control guidelines for healthcare professionals in the Netherlands: an evaluation of the process Open
Respondents emphasized the need for adaptation of generic guidelines into domain-specific guidelines, implying the necessity to develop guidelines that closely align with the needs of the field. Addressing areas for improvement - such as w…
View article: Dutch guideline for the prevention and control of multidrug-resistant organisms in the hospital setting, 2024 update
Dutch guideline for the prevention and control of multidrug-resistant organisms in the hospital setting, 2024 update Open
The emergence of multidrug-resistant organisms (MDROs) represents a significant challenge for global healthcare systems. The Netherlands maintains one of the lowest antimicrobial resistance rates in the world, attributed to prudent antibio…
View article: Cervicovaginal inflammation and HIV target cell activation in adolescent girls and young women with asymptomatic<i>Chlamydia trachomatis</i>infections
Cervicovaginal inflammation and HIV target cell activation in adolescent girls and young women with asymptomatic<i>Chlamydia trachomatis</i>infections Open
Background Adolescent girls and young women (AGYW) in sub-Saharan Africa are disproportionately affected by Chlamydia trachomatis (CT) infections, a leading cause of pelvic inflammatory disease (PID), infertility, and increased HIV suscept…
View article: High Prevalence and Genotypic Diversity of Persistent<i>Chlamydia trachomatis</i>Infections Among South African Adolescent Girls and Young Women: A Tale of Two Cities
High Prevalence and Genotypic Diversity of Persistent<i>Chlamydia trachomatis</i>Infections Among South African Adolescent Girls and Young Women: A Tale of Two Cities Open
Chlamydia trachomatis (CT) is the most common sexually transmitted bacterial infection globally, significantly affecting adolescent girls and young women (AGYW) in South Africa. This study investigated CT prevalence and genotypic diversity…
View article: Distribution and viability of ocular and non-ocular Chlamydia trachomatis in households in a trachoma-endemic community in Oromia, Ethiopia
Distribution and viability of ocular and non-ocular Chlamydia trachomatis in households in a trachoma-endemic community in Oromia, Ethiopia Open
Background We aimed to determine the household distribution and viability of Chlamydia trachomatis (Ct) from the eyes, face, and hands during the initial two visits of a year-long fortnightly cohort study in geographically defined adjacent…
View article: National Guidelines for Infection Prevention and Control in the Netherlands
National Guidelines for Infection Prevention and Control in the Netherlands Open
Nosocomial infections in healthcare impose a heavy and potentially life-threatening burden on patients and can inflate healthcare expenditures. From 1981 to 2017, the Dutch Working Party on Infection Prevention (Werkgroep infectiepreventie…
View article: Cluster randomised controlled trial of double-dose azithromycin mass drug administration, facial cleanliness and fly control measures for trachoma control in Oromia, Ethiopia: the stronger SAFE trial protocol
Cluster randomised controlled trial of double-dose azithromycin mass drug administration, facial cleanliness and fly control measures for trachoma control in Oromia, Ethiopia: the stronger SAFE trial protocol Open
Introduction Trachoma is caused by the bacterium Chlamydia trachomatis ( Ct ). The WHO recommends the SAFE strategy for trachoma elimination: Surgery for trichiasis, Antibiotics, Facial cleanliness and Environmental improvement. Multiple r…
View article: Field- and laboratory-based studies on correlates of Chlamydia trachomatis transmission by Musca sorbens: Determinants of fly-eye contact and investigations into fly carriage of elementary bodies
Field- and laboratory-based studies on correlates of Chlamydia trachomatis transmission by Musca sorbens: Determinants of fly-eye contact and investigations into fly carriage of elementary bodies Open
Musca sorbens (Diptera: Muscidae) flies are thought to be vectors of the blinding eye disease trachoma, carrying the bacterium Chlamydia trachomatis (Ct) between the eyes of individuals. While their role as vectors has been convincingly de…
View article: Trachoma risk factors in Oromia Region, Ethiopia
Trachoma risk factors in Oromia Region, Ethiopia Open
Background Trachoma, the leading infectious cause of blindness, is caused by the bacterium Chlamydia trachomatis (Ct). Despite enormous disease control efforts and encouraging progress, trachoma remains a significant public health problem …
View article: Ongoing evolution of Chlamydia trachomatis lymphogranuloma venereum: exploring the genomic diversity of circulating strains
Ongoing evolution of Chlamydia trachomatis lymphogranuloma venereum: exploring the genomic diversity of circulating strains Open
Lymphogranuloma venereum (LGV), the invasive infection of the sexually transmissible infection (STI) Chlamydia trachomatis , is caused by strains from the LGV biovar, most commonly represented by ompA -genotypes L2b and L2. We investigated…
View article: Viability PCR shows that non-ocular surfaces could contribute to transmission of Chlamydia trachomatis infection in trachoma
Viability PCR shows that non-ocular surfaces could contribute to transmission of Chlamydia trachomatis infection in trachoma Open
Plastic, cotton cloth and skin may contribute to transmission of the Ct strains that cause trachoma, by acting as sites where reservoirs of bacteria are deposited and later collected and transferred mechanically into previously uninfected …
View article: Prevalence of and risk factors for curable sexually transmitted infections on Bubaque Island, Guinea Bissau
Prevalence of and risk factors for curable sexually transmitted infections on Bubaque Island, Guinea Bissau Open
Objectives Complications from sexually transmitted infections (STIs) can result in severe morbidity and mortality. To date, no STI population studies have been conducted on the Bijagos Islands, Guinea Bissau. Our objective was to estimate …
View article: Detecting extra-ocular Chlamydia trachomatis in a trachoma-endemic community in Ethiopia: Identifying potential routes of transmission
Detecting extra-ocular Chlamydia trachomatis in a trachoma-endemic community in Ethiopia: Identifying potential routes of transmission Open
Ct DNA was detected on hands, faces and clothing of individuals living in ocular-positive households suggesting that this might be a route of transmission within Ct infected households. In addition, we detected Ct on flies from ocular-posi…
View article: Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease
Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease Open
A strong association between chromosomal genome, plasmid type and disease was observed, consistent with previous studies. This suggests co-evolution of the Ct chromosome and their plasmids, but we confirmed that plasmid transfer can occur …
View article: Additional file 2: Table S2. of Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease
Additional file 2: Table S2. of Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease Open
List of annotated loci present in the Chlamydiales pubMLST database. (XLSX 60Â kb)
View article: Additional file 1: Table S1. of Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease
Additional file 1: Table S1. of Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease Open
List of samples used in this study and associated metadata. (XLSX 20Â kb)
View article: Additional file 5: Table S4. of Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease
Additional file 5: Table S4. of Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease Open
List of genome genes and functions with respect to the allelic variance. (XLSX 58Â kb)
View article: Monitoring therapy success of urogenital Chlamydia trachomatis infections in women: A prospective observational cohort study
Monitoring therapy success of urogenital Chlamydia trachomatis infections in women: A prospective observational cohort study Open
Most RNA- or DNA-positive results after treatment of urogenital C. trachomatis may be caused by non-viable molecular remnants since they cannot be confirmed by culture. In a minority viable C. trachomatis was found in culture at the second…
View article: P1.06 In silico multilocus sequence typing of<i>chlamydia trachomatis</i>plasmids shows clustering of isolates according to the disease related biovars
P1.06 In silico multilocus sequence typing of<i>chlamydia trachomatis</i>plasmids shows clustering of isolates according to the disease related biovars Open
Introduction Nucleotide sequencing of the ompA gene, encoding the outer membrane protein MOMP, divides C. trachomatis into 15 main genovars comprising three biovars associated with different disease phenotypes along with distinct tissue tr…
View article: O06.5 Development of a human urethral equivalent to study<i>chlamydia trachomatis</i>invasion
O06.5 Development of a human urethral equivalent to study<i>chlamydia trachomatis</i>invasion Open
Introduction Chlamydia trachomatis (Ct) genovars D-K cause non-invasive urogenital infections, which often remain asymptomatic. Little is known about the invasion of the epithelial layer and the subsequent effects of Ct on the epithelium i…
View article: P3.18 Monitoring<i>chlamydia trachomatis</i>infections after treatment for test of cure purposes
P3.18 Monitoring<i>chlamydia trachomatis</i>infections after treatment for test of cure purposes Open
Introduction Performing a test of cure (TOC) could demonstrate success or failure of antimicrobial treatment of C. trachomatis (CT) infection, but the value of using a nuclear acid amplification test (NAAT) based TOC after treatment is sub…
View article: Low Prevalence of Urethral Lymphogranuloma Venereum Infections Among Men Who Have Sex With Men: A Prospective Observational Study, Sexually Transmitted Infection Clinic in Amsterdam, the Netherlands
Low Prevalence of Urethral Lymphogranuloma Venereum Infections Among Men Who Have Sex With Men: A Prospective Observational Study, Sexually Transmitted Infection Clinic in Amsterdam, the Netherlands Open
In contrast to anorectal lymphogranuloma venereum (LGV), few urogenital LGV cases are reported in men who have sex with men. Lymphogranuloma venereum was diagnosed in 0.06% (7/12,174) urine samples, and 0.9% (109/12,174) anorectal samples.…
View article: Concern regarding the alleged spread of hypervirulent lymphogranuloma venereum Chlamydia trachomatis strain in Europe
Concern regarding the alleged spread of hypervirulent lymphogranuloma venereum Chlamydia trachomatis strain in Europe Open
A recent surveillance and outbreak report published in Eurosurveillance by Petrovay et al. on the ‘Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016’ [1] provides an observation of the first European cases of…
View article: Does typing of Chlamydia trachomatis using housekeeping multilocus sequence typing reveal different sexual networks among heterosexuals and men who have sex with men?
Does typing of Chlamydia trachomatis using housekeeping multilocus sequence typing reveal different sexual networks among heterosexuals and men who have sex with men? Open
No distinct transmission of C. trachomatis could be observed in MSM and heterosexuals using the adapted MLST-7 scheme in contrast to using the hr-MLST-6. In addition, we compared clustering of both MLST schemes and demonstrated that typing…
View article: Lymphogranuloma Venereum with a Persistent Genital Ulcer and Lymphadenopathy as the only Symptoms
Lymphogranuloma Venereum with a Persistent Genital Ulcer and Lymphadenopathy as the only Symptoms Open
Genital ulcers can be caused by many infections. This case report describes a patient with a persistent genital ulcer and lymphadenopathy. Although the patient had no other symptoms, and urine samples and rectal swabs were negative for Chl…