Bartholomeus T. van den Berge

Biopsy Morphometrics as Predictors of Treatment Response in Primary Nephrotic Syndrome Open

Bartholomeus T. van den Berge, Jitske Jansen, Quinty Leusink, Sanne Kleuskens, Sharon Bootsman , et al. · 2025

Podocyte Glucocorticoid Receptor Expression and Treatment Outcome in Idiopathic Nephrotic Syndrome Open

Bartholomeus T. van den Berge, Jitske Jansen, Jack F M Wetzels, Bart Smeets, Rutger Maas · 2025

Personalized disease recurrence modeling using iPSC-derived podocytes in patients with idiopathic nephrotic syndrome Open

Bartholomeus T. van den Berge, Martijn van den Broek, Gianluca Di Giovanni, Hanna Dębiec, Sharon Gloudemans , et al. · 2025

Background Primary focal segmental glomerulosclerosis (FSGS) is characterized by podocyte injury and treatment-resistant nephrotic syndrome. Recurrence of the original disease after kidney transplantation (rFSGS) occurs in 10%–50% of patie…

Levamisole Modulation of Podocytes’ Actin Cytoskeleton in Nephrotic Syndrome Open

Susan T. Veissi, Bartholomeus T. van den Berge, J. A. E. van Wijk, Thea J. A. M. van der Velden, René Classens , et al. · 2023

Podocytes play a central role in glomerular diseases such as (idiopathic) nephrotic syndrome (iNS). Glucocorticoids are the gold standard therapy for iNS. Nevertheless, frequent relapses are common. In children with iNS, steroid-sparing ag…

Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells Open

Jennifer Eymael, Martijn van den Broek, Laura Miesen, Valerie Villacorta Monge, Bartholomeus T. van den Berge , et al. · 2022

Scattered tubular cells (STCs) are a phenotypically distinct cell population in the proximal tubule that increase in number after acute kidney injury. We aimed to characterize the human STC population. Three‐dimensional human tissue analys…

Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling Open

Jitske Jansen, Bartholomeus T. van den Berge, Martijn van den Broek, Rutger Maas, Deniz Daviran , et al. · 2022

Nephrotic syndrome (NS) is characterized by severe proteinuria as a consequence of kidney glomerular injury due to podocyte damage. In vitro models mimicking in vivo podocyte characteristics are a prerequisite to resolve NS pathogenesis. T…

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids Open

Jitske Jansen, Katharina C. Reimer, James S. Nagai, Finny S. Varghese, Gijs J. Overheul , et al. · 2021

Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling Open

Jitske Jansen, Bartholomeus T. van den Berge, Martijn van den Broek, Rutger Maas, Brigith Willemsen , et al. · 2021

Nephrotic syndrome (NS) is characterized by severe proteinuria as a consequence of kidney glomerular injury due to podocyte damage. In vitro models mimicking in vivo podocyte characteristics are a prerequisite to resolve NS pathogenesis. H…

Establishment and characterization of a novel conditionally immortalized human parietal epithelial cell line Open

Laura Miesen, Roy Wetzels, Jennifer Eymael, Fieke Mooren, Valerie Villacorta Monge , et al. · 2021

Parietal epithelial cells (PECs) are epithelial cells in the kidney, surrounding Bowman's space. When activated, PECs increase in cell volume, proliferate, migrate to the glomerular tuft and excrete extracellular matrix. Activated PECs are…

Nephron Number as Predictor of Corticosteroid Response in Adult Minimal Change Disease Open

Bartholomeus T. van den Berge, Rutger Maas · 2020

Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells Open

Jelle Vriend, Charlotte A. Hoogstraten, Kevin R. Venrooij, Bartholomeus T. van den Berge, Larissa P. Govers , et al. · 2019

Organic anion transporters (OATs) 1 and 3 are, besides being uptake transporters, key in several cellular metabolic pathways. The underlying mechanisms are largely unknown. Hence, we used human conditionally immortalized proximal tubule ep…

Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip Open

Jelle Vriend, Tom T.G. Nieskens, Marianne K. Vormann, Bartholomeus T. van den Berge, Angelique van den Heuvel , et al. · 2018

Drug-transporter interactions could impact renal drug clearance and should ideally be detected in early stages of drug development to avoid toxicity-related withdrawals in later stages. This requires reliable and robust assays for which cu…

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