Bartolomé R. Celli
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View article: Corrigendum to “Disease burden and health-related outcomes of patients discharged from hospital following a COPD exacerbation in the United States” [Respir. Med. 248 (2025) 108337]
Corrigendum to “Disease burden and health-related outcomes of patients discharged from hospital following a COPD exacerbation in the United States” [Respir. Med. 248 (2025) 108337] Open
View article: Maternal Smoking and CC-16: Implications for Lung Development and COPD Across the Lifespan
Maternal Smoking and CC-16: Implications for Lung Development and COPD Across the Lifespan Open
Maternal smoking was linked to reduced circulating and airway CC16 in COPD patients, controls, and a preclinical murine COPD model. In human adults, lower CC16 correlated with accelerated lung function decline and emphysema progression, wh…
View article: Disease burden and health-related outcomes of patients discharged from hospital following a COPD exacerbation in the United States
Disease burden and health-related outcomes of patients discharged from hospital following a COPD exacerbation in the United States Open
Treatment patterns post-hospitalization for a COPD exacerbation in the U.S. don't align with recognized standards (e.g. GOLD recommendations). Patients discharged from hospital post-COPD exacerbation have a high risk of severe cardiopulmon…
View article: A person-centred clinical approach to the multimorbid patient with COPD
A person-centred clinical approach to the multimorbid patient with COPD Open
Most patients with a chronic disease are multimorbid. This is particularly important in patients with chronic obstructive pulmonary disease (COPD), who on average have five other identified comorbidities that independently impact their hea…
View article: Reply to Bardsley <i>et al.</i> : Current Smoking and Pharmacological Treatment Responses in Chronic Obstructive Pulmonary Disease: Not Clear-Cut
Reply to Bardsley <i>et al.</i> : Current Smoking and Pharmacological Treatment Responses in Chronic Obstructive Pulmonary Disease: Not Clear-Cut Open
View article: Form Is Function: Predicting <scp>COPD</scp> Outcomes With Respiratory Muscle Dysfunction
Form Is Function: Predicting <span>COPD</span> Outcomes With Respiratory Muscle Dysfunction Open
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View article: Current Smoker: A Clinical Chronic Obstructive Pulmonary Disease Phenotype Affecting Disease Progression and Response to Therapy
Current Smoker: A Clinical Chronic Obstructive Pulmonary Disease Phenotype Affecting Disease Progression and Response to Therapy Open
Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition of the lungs, characterized by chronic respiratory symptoms, primarily dyspnea, cough, and sputum production, due to airway and/or alveoli abnormalities that cause p…
View article: Low Lung Function in Middle-Aged Smokers Impacts Health Status, Morbidities, and Mortality: An Observational Analysis of the Lovelace Smokers Cohort
Low Lung Function in Middle-Aged Smokers Impacts Health Status, Morbidities, and Mortality: An Observational Analysis of the Lovelace Smokers Cohort Open
Smokers with LLF without airflow obstruction exhibited reduced survival and an increased risk for development of chronic morbidities. Thus, spirometry may be used to identify at-risk individuals, allowing for early preventative interventio…
View article: Prospective COPD Case Finding in a Lung Cancer Screening Program: A Pilot Study
Prospective COPD Case Finding in a Lung Cancer Screening Program: A Pilot Study Open
The CAPTURE tool is an effective method to find COPD cases in lung cancer screenings. A CT diagnosis of emphysema can substitute peak flow in this population.
View article: Phosphodiesterase Inhibition as a Therapeutic Strategy for Chronic Obstructive Pulmonary Disease: Where We Have Been and What Lies Ahead
Phosphodiesterase Inhibition as a Therapeutic Strategy for Chronic Obstructive Pulmonary Disease: Where We Have Been and What Lies Ahead Open
Chronic obstructive pulmonary disease (COPD) is a highly prevalent inflammatory lung condition characterized by chronic respiratory symptoms and airflow obstruction that often leads to diminished quality of life. Nonpharmacologic managemen…
View article: GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD
GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD Open
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) report states that the diagnosis of COPD should be considered in individuals with chronic respiratory symptoms and/or exposure to risk factors. Forced spirometry demonstrati…
View article: Contrasting the clinical and biological characteristics of young and old COPD patients
Contrasting the clinical and biological characteristics of young and old COPD patients Open
Background The ECLIPSE study was a large, international, prospective, controlled, observational study that included COPD patients (Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 2–4), as well as smoking and non-smokin…
View article: Managing and discharging COPD patients hospitalized because of an exacerbation of respiratory symptoms: An opportunity to improve outcomes
Managing and discharging COPD patients hospitalized because of an exacerbation of respiratory symptoms: An opportunity to improve outcomes Open
View article: BMI-related Genetic Factors and COPD Imaging Phenotypes
BMI-related Genetic Factors and COPD Imaging Phenotypes Open
Background While low body mass index (BMI) is associated with emphysema and obesity is associated with airway disease in chronic obstructive pulmonary disease (COPD), the underlying mechanisms are unclear. Methods We aggregated genetic var…
View article: To Our Knowledge, You Are Not the First...
To Our Knowledge, You Are Not the First... Open
"To Our Knowledge, You Are Not the First...." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Effectiveness of ICS/LABA and LAMA/LABA in COPD due to biomass
Effectiveness of ICS/LABA and LAMA/LABA in COPD due to biomass Open
Background COPD due to biomass exposure (COPD-B) is highly prevalent in low- and middle-income countries, and there are no clinical trials designed to evaluate the effectiveness of the treatments currently recommended for patients with COP…
View article: Increasing exercise capacity and physical activity in the COPD patient
Increasing exercise capacity and physical activity in the COPD patient Open
Higher levels of exercise capacity and physical activity are desired outcomes in the comprehensive management of the COPD patient. In addition, improvements in exercise capacity and physical activity are instrumental to optimising other im…
View article: Prevalence and prognostic importance of exercise limitation and physical inactivity in COPD
Prevalence and prognostic importance of exercise limitation and physical inactivity in COPD Open
Exercise limitation and physical inactivity are separate, but related constructs. Both are commonly present in individuals with COPD, contribute to disease burden over and above the respiratory impairments, and are independently predictive…
View article: Triple Therapy and Clinical Control in B+ COPD Patients: A Pragmatic, Prospective, Randomized Trial
Triple Therapy and Clinical Control in B+ COPD Patients: A Pragmatic, Prospective, Randomized Trial Open
The ANTES B+ study is the first to: (1) explore the efficacy and safety of triple therapy in a population of B+ COPD patients and (2) use a composite index (CC) as the primary result of a COPD trial.
View article: Early Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease: The Costs and Benefits of Case Finding
Early Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease: The Costs and Benefits of Case Finding Open
"Early Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease: The Costs and Benefits of Case Finding." American Journal of Respiratory and Critical Care Medicine, 209(8), pp. 928–937
View article: Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers
Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers Open
Lung cancer (LC) constitutes an important cause of death among patients with Chronic Obstructive Pulmonary Disease (COPD). Both diseases may share pathobiological mechanisms related to oxidative damage and cellular senescence. In this stud…
View article: Sputum Biomarkers in Wood and Tobacco Smoke Etiotypes of Chronic Obstructive Pulmonary Disease
Sputum Biomarkers in Wood and Tobacco Smoke Etiotypes of Chronic Obstructive Pulmonary Disease Open
While sputum concentrations of MMP-9, IL-8, and CCL5 were higher in COPD women compared with controls, women with TS-COPD had higher levels of CCL5 compared with those with WS-COPD. Whether this finding relates to differences in pathobiolo…
View article: Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts: The BODE and CHAIN Experience
Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts: The BODE and CHAIN Experience Open
An important proportion of patients from 2 GOLD-defined COPD cohorts did not meet GLI AL criteria at enrolment, although they had a significant burden of disease. Caution must be taken when applying the GLI AL criteria in clinical practice.
View article: From pre-COPD to COPD: a Simple, Low cost and easy to IMplement (SLIM) risk calculator
From pre-COPD to COPD: a Simple, Low cost and easy to IMplement (SLIM) risk calculator Open
Background The lifetime risk of developing clinical COPD among smokers ranges from 13% to 22%. Identifying at-risk individuals who will develop overt disease in a reasonable timeframe may allow for early intervention. We hypothesised that …
View article: Circulating miR-206 and miR-1246 as Markers in the Early Diagnosis of Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease
Circulating miR-206 and miR-1246 as Markers in the Early Diagnosis of Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease Open
Lung cancer (LC) is the most common cause of cancer death, with 75% of cases being diagnosed in late stages. This study aimed to determine potential miRNAs as biomarkers for the early detection of LC in chronic obstructive pulmonary diseas…
View article: Gold 2023: Highlights for primary care
Gold 2023: Highlights for primary care Open
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has issued its 2023 annual report1. Compared with former versions, it has been significantly updated. Here, we summarize the most relevant changes for a Primary Care audienc…
View article: Use of thiols and implications for the use of inhaled corticosteroids in the presence of oxidative stress in COPD
Use of thiols and implications for the use of inhaled corticosteroids in the presence of oxidative stress in COPD Open
Background Oxidative stress and persistent airway inflammation are thought to be important contributors to the development of chronic obstructive pulmonary disease (COPD). This review summarizes the evidence for targeting oxidative stress …
View article: Targeting Type 2 Inflammation and Epithelial Alarmins in Chronic Obstructive Pulmonary Disease: A Biologics Outlook
Targeting Type 2 Inflammation and Epithelial Alarmins in Chronic Obstructive Pulmonary Disease: A Biologics Outlook Open
Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous, progressive inflammatory airway disease associated with a significant impact on patients' lives, including morbidity and mortality, and significant healthcare costs.…
View article: GOLD 2023 Executive Summary: responses from the GOLD Scientific Committee
GOLD 2023 Executive Summary: responses from the GOLD Scientific Committee Open
The GOLD Scientific Committee respond to five letters to the Editor in relation to the GOLD 2023 Executive Summary https://bit.ly/41wJzhk
View article: GOLD COPD DOCUMENT 2023: a brief update for practicing cardiologists
GOLD COPD DOCUMENT 2023: a brief update for practicing cardiologists Open