Peter Bärtsch
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View article: Acute changes in cardiac dimensions, function, and longitudinal mechanics in healthy individuals with and without high‐altitude induced pulmonary hypertension at 4559 m
Acute changes in cardiac dimensions, function, and longitudinal mechanics in healthy individuals with and without high‐altitude induced pulmonary hypertension at 4559 m Open
Background High‐altitude pulmonary hypertension (HAPH) has a prevalence of approximately 10%. Changes in cardiac morphology and function at high altitude, compared to a population that does not develop HAPH are scarce. Methods Four hundred…
View article: Prevalence and knowledge about acute mountain sickness in the Western Alps
Prevalence and knowledge about acute mountain sickness in the Western Alps Open
Objective To assess the prevalence of acute mountain sickness (AMS) in 1370 mountaineers at four different altitudes in the Western Alps. We also examined the influence of potential risk factors and the knowledge about AMS on its prevalenc…
View article: An update on environment-induced pulmonary edema – “When the lungs leak under water and in thin air”
An update on environment-induced pulmonary edema – “When the lungs leak under water and in thin air” Open
Acute pulmonary edema is a serious condition that may occur as a result of increased hydrostatic forces within the lung microvasculature or increased microvascular permeability. Heart failure or other cardiac or renal disease are common ca…
View article: Strengthening Altitude Knowledge: A Delphi Study to Define Minimum Knowledge of Altitude Illness for Laypersons Traveling to High Altitude
Strengthening Altitude Knowledge: A Delphi Study to Define Minimum Knowledge of Altitude Illness for Laypersons Traveling to High Altitude Open
Berendsen, Remco R., Peter Bärtsch, Buddha Basnyat, Marc Moritz Berger, Peter Hackett, Andrew M. Luks, Jean-Paul Richalet, Ken Zafren, Bengt Kayser, and the STAK Plenary Group. Strengthening altitude knowledge: a Delphi study to define min…
View article: Midkine release during hemodialysis is predictive of hypervolemia and associates with excess (cardiovascular) mortality in patients with end-stage renal disease: a prospective study
Midkine release during hemodialysis is predictive of hypervolemia and associates with excess (cardiovascular) mortality in patients with end-stage renal disease: a prospective study Open
Background In end-stage renal disease, a high cardiovascular risk profile and endothelial damage prevails. The heparin-binding growth factor midkine stimulates neo-angiogenesis in ischemic diseases, coordinates neutrophil influx, and raise…
View article: Redescription and validation of Alphestes afer as an amphi-Atlantic grouper species (Perciformes: Serranidae)
Redescription and validation of Alphestes afer as an amphi-Atlantic grouper species (Perciformes: Serranidae) Open
Alphestes afer (Bloch, 1793), a common western Atlantic species of grouper, was described from the coast of Guinea, West Africa. The type locality has long been regarded as erroneous, and the presence of this species in the eastern Atlanti…
View article: No renal dysfunction or salt and water retention in acute mountain sickness at 4,559 m among young resting males after passive ascent
No renal dysfunction or salt and water retention in acute mountain sickness at 4,559 m among young resting males after passive ascent Open
Kidney function remained essentially unaffected and acute mountain sickness (AMS) was not associated with salt and water retention in healthy young men flown to and resting at the Margherita hut (4,559 m) under strictly controlled conditio…
View article: DataSet of "No renal dysfunction or salt and water retention in acute mountain sickness at 4,559 m among young resting males after passive ascent"
DataSet of "No renal dysfunction or salt and water retention in acute mountain sickness at 4,559 m among young resting males after passive ascent" Open
Abstract Purpose: This study examined the role and function of the kidney at high altitude in relation to fluid balance and the development of acute mountain sickness (AMS), avoiding confounders that have contributed to conflicting results…
View article: DataSet of "No renal dysfunction or salt and water retention in acute mountain sickness at 4,559 m among young resting males after passive ascent"
DataSet of "No renal dysfunction or salt and water retention in acute mountain sickness at 4,559 m among young resting males after passive ascent" Open
Abstract Purpose: This study examined the role and function of the kidney at high altitude in relation to fluid balance and the development of acute mountain sickness (AMS), avoiding confounders that have contributed to conflicting results…
View article: Acute high-altitude illness: updated principles ofpathophysiology, prevention, and treatment
Acute high-altitude illness: updated principles ofpathophysiology, prevention, and treatment Open
The interest in trekking and mountaineering is increasing, and growing numbers of individuals are travelling to high altitude. Following ascent to high altitude, individuals are at risk of developing one of the three forms of acute high-al…
View article: A cephalic sensory system with a suggested mechanoreceptive function in two pentanchine Scyliorhinidae (Elasmobranchii)
A cephalic sensory system with a suggested mechanoreceptive function in two pentanchine Scyliorhinidae (Elasmobranchii) Open
The heads of three scyliorhinid sharks (Scyliorhinus canicula, Galeus melastomus, Apristurus aphyodes) were investigated histologically in order to clarify the anatomy of the electroreceptive system (ampullae of Lorenzini). Complexes of am…
View article: Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases
Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases Open
The European Respiratory Society (ERS) Research Seminar entitled “Pulmonary vascular endothelium: orchestra conductor in respiratory diseases - highlights from basic research to therapy” brought together international experts in dysfunctio…
View article: The 2018 Lake Louise Acute Mountain Sickness Score
The 2018 Lake Louise Acute Mountain Sickness Score Open
Roach, Robert C., Peter H. Hackett, Oswald Oelz, Peter Bärtsch, Andrew M. Luks, Martin J. MacInnis, J. Kenneth Baillie, and The Lake Louise AMS Score Consensus Committee. The 2018 Lake Louise Acute Mountain Sickness Score. High Alt Med Bio…
View article: The STAR Data Reporting Guidelines for Clinical High Altitude Research
The STAR Data Reporting Guidelines for Clinical High Altitude Research Open
The STAR initiative, using the Delphi method, identified a set of key parameters essential for research and reporting in clinical HA medicine.
View article: Clinical recommendations for high altitude exposure of individuals with pre-existing cardiovascular conditions
Clinical recommendations for high altitude exposure of individuals with pre-existing cardiovascular conditions Open
Take home figureAdapted from Bärtsch and Gibbs2 Physiological response to hypoxia. Life-sustaining oxygen delivery, in spite of a reduction in the partial pressure of inhaled oxygen between 25% and 60% (respectively at 2500 m and 8000 m), …
View article: Inhaled budesonide does not prevent acute mountain sickness after rapid ascent to 4559 m
Inhaled budesonide does not prevent acute mountain sickness after rapid ascent to 4559 m Open
Recent studies showed that inhaled budesonide (200 µg twice per day) reduced the incidence of acute mountain sickness (AMS) after passive ascent to 3700 and 3900 m [1, 2]. These findings raised the possibility that mediators released from …
View article: Reproduction and development of the asian bronze featherback Notopterus notopterus (Pallas, 1769) (Osteoglossiformes, Notopteridae) in captivity
Reproduction and development of the asian bronze featherback Notopterus notopterus (Pallas, 1769) (Osteoglossiformes, Notopteridae) in captivity Open
Experimental data demonstrate that the environmental factors decreasing conductivity, slight variation of temperature, and water level have no influence on gonad development or courtship behavior in Notopterus notopterus. Spawning occurs d…
View article: Acute high-altitude sickness
Acute high-altitude sickness Open
At any point 1–5 days following ascent to altitudes ≥2500 m, individuals are at risk of developing one of three forms of acute altitude illness: acute mountain sickness, a syndrome of nonspecific symptoms including headache, lassitude, diz…
View article: Lower hypoxic ventilatory response in smokers compared to non-smokers during abstinence from cigarettes
Lower hypoxic ventilatory response in smokers compared to non-smokers during abstinence from cigarettes Open
This is the first report of a substantial HVR reduction in abstinent adult smokers which appears to be masked by daily smoking routine and may therefore have been previously overlooked. A low HVR may be suggested as a novel link between sm…
View article: Inhibition of alveolar Na transport and LPS causes hypoxemia and pulmonary arterial vasoconstriction in ventilated rats
Inhibition of alveolar Na transport and LPS causes hypoxemia and pulmonary arterial vasoconstriction in ventilated rats Open
Oxygen diffusion across the alveolar wall is compromised by low alveolar oxygen but also by pulmonary edema, and leads to hypoxemia and hypoxic pulmonary vasoconstriction (HPV). To test, whether inhibition of alveolar fluid reabsorption re…
View article: Additional file 1: of Lower hypoxic ventilatory response in smokers compared to non-smokers during abstinence from cigarettes
Additional file 1: of Lower hypoxic ventilatory response in smokers compared to non-smokers during abstinence from cigarettes Open
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View article: Response to the letter: role of remote ischemic preconditioning against acute mountain sickness during early phase by Sikri and Chawla
Response to the letter: role of remote ischemic preconditioning against acute mountain sickness during early phase by Sikri and Chawla Open
We thank Dr. Sikri and Dr. Chawla for their interest in our study. The severity and incidence of AMS were quantified by using the Lake Louise scoring protocol and the AMS-C score of the Environmental Symptom Questionnaire. Subjects were cl…
View article: Remote ischemic preconditioning for prevention of high-altitude diseases: fact or fiction?
Remote ischemic preconditioning for prevention of high-altitude diseases: fact or fiction? Open
Preconditioning refers to exposure to brief episodes of potentially adverse stimuli and protects against injury during subsequent exposures. This was first described in the heart, where episodes of ischemia/reperfusion render the myocardiu…