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View article: Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies
Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies Open
Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL) can mediate tumor regression, including complete and durable responses, in a range of solid cancers, most notably in melanoma. However, its wider application and efficacy has …
View article: Structural Property Prediction
Structural Property Prediction Open
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims …
View article: Introduction to Protein Structure
Introduction to Protein Structure Open
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims …
View article: Data Resources for Structural Bioinformatics
Data Resources for Structural Bioinformatics Open
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims …
View article: Function Prediction
Function Prediction Open
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims …
View article: 241 Development of a personalized neoantigen-specific TCR discovery platform
241 Development of a personalized neoantigen-specific TCR discovery platform Open
Background Tumor-infiltrating lymphocyte (TIL) therapy can mediate tumor regression in a range of solid cancers, most notably in melanoma. However, its wider application and efficacy has been limited by the low frequency and exhausted phen…
View article: PIPENN: protein interface prediction from sequence with an ensemble of neural nets
PIPENN: protein interface prediction from sequence with an ensemble of neural nets Open
Motivation The interactions between proteins and other molecules are essential to many biological and cellular processes. Experimental identification of interface residues is a time-consuming, costly and challenging task, while protein seq…
View article: PIPENN: Protein Interface Prediction with an Ensemble of Neural Nets
PIPENN: Protein Interface Prediction with an Ensemble of Neural Nets Open
Motivation Protein interactions play an essential role in many biological and cellular processes, such as protein–protein interaction (PPI) in signaling pathways, binding to DNA in transcription, and binding to small molecules in receptor …
View article: Structure determination
Structure determination Open
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims …
View article: SeRenDIP-CE: sequence-based interface prediction for conformational epitopes
SeRenDIP-CE: sequence-based interface prediction for conformational epitopes Open
Motivation Antibodies play an important role in clinical research and biotechnology, with their specificity determined by the interaction with the antigen’s epitope region, as a special type of protein–protein interaction (PPI) interface. …
View article: SeRenDIP-CE: Sequence-based Interface Prediction for Conformational Epitopes
SeRenDIP-CE: Sequence-based Interface Prediction for Conformational Epitopes Open
Motivation Antibodies play an important role in clinical research and biotechnology, with their specificity determined by the interaction with the antigen’s epitope region, as a special type of protein-protein interaction (PPI) interface. …
View article: Systematically linking tranSMART, Galaxy and EGA for reusing human translational research data
Systematically linking tranSMART, Galaxy and EGA for reusing human translational research data Open
The availability of high-throughput molecular profiling techniques has provided more accurate and informative data for regular clinical studies. Nevertheless, complex computational workflows are required to interpret these data. Over the p…