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View article: Fast In Vitro Synthesis and Direct Labeling of Nanobodies for Prototyping in Microscopy Applications
Fast In Vitro Synthesis and Direct Labeling of Nanobodies for Prototyping in Microscopy Applications Open
Small antigen binders, such as nanobodies, have become widely used in biomedical research and pharmaceutical development. However, the pipeline for the generation of functional conjugated probes and drugs from identified binders remains a …
View article: Efficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination
Efficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination Open
In neurons, the microtubule (MT) cytoskeleton forms the basis for long-distance protein transport from the cell body into and out of dendrites and axons. To maintain neuronal polarity, the axon initial segment (AIS) serves as a physical ba…
View article: Efficient axonal trafficking of endolysosomes depends on the balanced ratio of microtubule tyrosination and detyrosination
Efficient axonal trafficking of endolysosomes depends on the balanced ratio of microtubule tyrosination and detyrosination Open
In neurons, the microtubule (MT) cytoskeleton forms the basis for long-distance protein transport from the cell body into and out of dendrites and axon. To maintain neuronal polarity, the axon initial segment (AIS) serves as a physical bar…
View article: Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology
Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology Open
The vast majority of excitatory synapses are formed on small dendritic protrusions termed dendritic spines. Dendritic spines vary in size and density that are crucial determinants of excitatory synaptic transmission. Aberrations in spine m…
View article: Spike-timing-dependent plasticity rewards synchrony rather than causality
Spike-timing-dependent plasticity rewards synchrony rather than causality Open
Spike-timing-dependent plasticity (STDP) is a candidate mechanism for information storage in the brain, but the whole-cell recordings required for the experimental induction of STDP are typically limited to 1 h. This mismatch of time scale…
View article: Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology
Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology Open
The vast majority of excitatory synapses are formed on small dendritic protrusions termed dendritic spines. Dendritic spines vary in size and density that are both crucial determinants of excitatory synaptic transmission. Aberrations in sp…
View article: Spike-timing-dependent plasticity rewards synchrony rather than causality
Spike-timing-dependent plasticity rewards synchrony rather than causality Open
Spike-timing-dependent plasticity (STDP) is a candidate mechanism for information storage in the brain, but the whole-cell recordings required for the experimental induction of STDP are typically limited to one hour. This mismatch of time …
View article: F-actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes
F-actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes Open
Organelle positioning within neurites is required for proper neuronal function. In dendrites with their complex cytoskeletal organization, transport of organelles is guided by local specializations of the microtubule and actin cytoskeleton…
View article: Ton van Kalmthout, Huib Zuidervaart (eds.), The Practice of Philology in the Nineteenth-Century Netherlands
Ton van Kalmthout, Huib Zuidervaart (eds.), The Practice of Philology in the Nineteenth-Century Netherlands Open
Ton van Kalmthout, Huib Zuidervaart (eds.), The Practice of Philology in the Nineteenth-Century Netherlands (History of Science and Scholarship in the Netherlands 14; Amsterdam: Amsterdam University Press, 2015, 258 pp., ISBN 978 90 8964 5…
View article: Ton van Kalmthout, Huib Zuidervaart (eds.), The Practice of Philology in the Nineteenth-Century Netherlands
Ton van Kalmthout, Huib Zuidervaart (eds.), The Practice of Philology in the Nineteenth-Century Netherlands Open
Ton van Kalmthout, Huib Zuidervaart (eds.), The Practice of Philology in the Nineteenth-Century Netherlands (History of Science and Scholarship in the Netherlands 14; Amsterdam: Amsterdam University Press, 2015, 258 pp., ISBN 978 90 8964 5…