Basem Kanawati
YOU?
Author Swipe
View article: Blue‐green fluorescence during hypersensitive cell death arises from phenylpropanoid deydrodimers
Blue‐green fluorescence during hypersensitive cell death arises from phenylpropanoid deydrodimers Open
Infection of Arabidopsis with avirulent Pseudomonas syringae and exposure to nitrogen dioxide (NO 2 ) both trigger hypersensitive cell death (HCD) that is characterized by the emission of bright blue‐green (BG) autofluorescence under UV il…
View article: Interplay of Metallome and Metabolome in Amyotrophic Lateral Sclerosis: A Study on Cerebrospinal Fluid of Patients Carrying Disease-Related Gene Mutations
Interplay of Metallome and Metabolome in Amyotrophic Lateral Sclerosis: A Study on Cerebrospinal Fluid of Patients Carrying Disease-Related Gene Mutations Open
Amyotrophic lateral sclerosis (ALS) is a lethal progressive neurodegenerative disease, characterized by a loss of function of upper and lower motor neurons. This study aimed to explore probable pathological alterations occurring in individ…
View article: Advanced Mass Spectrometric Techniques for the Comprehensive Study of Synthesized Silicon-Based Silyl Organic Compounds: Identifying Fragmentation Pathways and Characterization
Advanced Mass Spectrometric Techniques for the Comprehensive Study of Synthesized Silicon-Based Silyl Organic Compounds: Identifying Fragmentation Pathways and Characterization Open
The primary objective of this study was to synthesize and characterize novel silicon-based silyl organic compounds in order to gain a deeper understanding of their potential applications and interactions with other compounds. Four new arti…
View article: Cell wall strengthening by phenylpropanoid dehydrodimers during the plant hypersensitive cell death
Cell wall strengthening by phenylpropanoid dehydrodimers during the plant hypersensitive cell death Open
Infection of Arabidopsis with avirulent Pseudomonas syringae and exposure to nitrogen dioxide (NO 2 ) both trigger hypersensitive cell death (HCD) that is characterized by the emission of bright blue-green (BG) autofluorescence under UV il…
View article: Large-Scale Interlaboratory DI-FT-ICR MS Comparability Study Employing Various Systems
Large-Scale Interlaboratory DI-FT-ICR MS Comparability Study Employing Various Systems Open
Ultrahigh resolution mass spectrometry (UHR-MS) coupled with direct infusion (DI) electrospray ionization offers a fast solution for accurate untargeted profiling. Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers have …
View article: Dihydrogen phosphate anion boosts the detection of sugars in electrospray ionization mass spectrometry: A combined experimental and computational investigation
Dihydrogen phosphate anion boosts the detection of sugars in electrospray ionization mass spectrometry: A combined experimental and computational investigation Open
Rationale Sugars are key molecules of life but challenging to detect via electrospray ionization mass spectrometry (ESI‐MS). Unfortunately, sugars are challenging analytes for mass spectrometric methods due to their high gas‐phase deproton…
View article: Thermal History of Asteroid Parent Bodies Is Reflected in Their Metalorganic Chemistry
Thermal History of Asteroid Parent Bodies Is Reflected in Their Metalorganic Chemistry Open
Organo-magnesium compounds were shown to contribute significantly to the soluble carbon molecular complexity and diversity of meteorites, and their analysis increases our knowledge on carbon stabilization/sequestration processes in the ast…
View article: Comprehensive Analysis of the <i>Alternaria</i> Mycobolome Using Mass Spectrometry Based Metabolomics
Comprehensive Analysis of the <i>Alternaria</i> Mycobolome Using Mass Spectrometry Based Metabolomics Open
Scope Alternaria fungi are widely distributed plant pathogens infecting grains and vegetables and causing major harvest losses in the field and during postharvest storage. Besides, consumers are endangered by the formation of toxic seconda…
View article: Metabolomic investigations in cerebrospinal fluid of Parkinson's disease
Metabolomic investigations in cerebrospinal fluid of Parkinson's disease Open
The underlying mechanisms of Parkinson´s disease are not completely revealed. Especially, early diagnostic biomarkers are lacking. To characterize early pathophysiological events, research is focusing on metabolomics. In this case-control …
View article: Short-Term Exposure to Nitrogen Dioxide Provides Basal Pathogen Resistance
Short-Term Exposure to Nitrogen Dioxide Provides Basal Pathogen Resistance Open
Nitrogen dioxide (NO2) forms in plants under stress conditions, but little is known about its physiological functions. Here, we explored the physiological functions of NO2 in plant cells using short-term fumigation of Arabidopsis (Arabidop…
View article: Usage of FT-ICR-MS Metabolomics for Characterizing the Chemical Signatures of Barrel-Aged Whisky
Usage of FT-ICR-MS Metabolomics for Characterizing the Chemical Signatures of Barrel-Aged Whisky Open
Whisky can be described as a complex matrix integrating the chemical history from the fermented cereals, the wooden barrels, the specific distillery processes, aging, and environmental factors. In this study, using Fourier transform ion cy…
View article: Previously unknown class of metalorganic compounds revealed in meteorites
Previously unknown class of metalorganic compounds revealed in meteorites Open
Significance In this study we report the discovery of a previously unrecognized chemical class, dihydroxymagnesium carboxylates, [(HO) 2 MgO 2 CR] − , gained from nonterrestrial meteoritic analyses. The existence of such low-coordination o…
View article: Metabolic Fingerprint of PS3-Induced Resistance of Grapevine Leaves against Plasmopara viticola Revealed Differences in Elicitor-Triggered Defenses
Metabolic Fingerprint of PS3-Induced Resistance of Grapevine Leaves against Plasmopara viticola Revealed Differences in Elicitor-Triggered Defenses Open
Induction of plant resistance against pathogens by defense elicitors constitutes an attractive strategy to reduce the use of fungicides in crop protection. However, all elicitors do not systematically confer protection against pathogens. E…
View article: Additional file 2: of Relationships between drought, heat and air humidity responses revealed by transcriptome-metabolome co-analysis
Additional file 2: of Relationships between drought, heat and air humidity responses revealed by transcriptome-metabolome co-analysis Open
Result lists for stress combination analysis. Mass and gene classifications are provided according to the combined stress model depicted in Fig. 2. Classification is carried out with respect to the regulation in drought stress (D), the reg…
View article: Additional file 4: of Relationships between drought, heat and air humidity responses revealed by transcriptome-metabolome co-analysis
Additional file 4: of Relationships between drought, heat and air humidity responses revealed by transcriptome-metabolome co-analysis Open
Result lists for air humidity analysis. Mass and gene lists as well as enriched GO terms are given for the Venn groups in Fig. 3a and b, distinguishing low air humidity-specific variables (LrH only), high air humidity-specific variables (H…
View article: Additional file 6: of Relationships between drought, heat and air humidity responses revealed by transcriptome-metabolome co-analysis
Additional file 6: of Relationships between drought, heat and air humidity responses revealed by transcriptome-metabolome co-analysis Open
Results lists for network communities of correlated genes and metabolic masses. The graph structure of each network community shown in Fig. 5b and c is given in dot format readable by Graphviz ( http://www.graphviz.org ), and significantly…
View article: Additional file 3: of Relationships between drought, heat and air humidity responses revealed by transcriptome-metabolome co-analysis
Additional file 3: of Relationships between drought, heat and air humidity responses revealed by transcriptome-metabolome co-analysis Open
Result lists of condition-specific gene expression and metabolomic mass levels estimated by linear modeling across the whole dataset. Tables show mean log2 gene expression values and log2metabolomic mass levels for each of the six environm…
View article: Additional file 5: of Relationships between drought, heat and air humidity responses revealed by transcriptome-metabolome co-analysis
Additional file 5: of Relationships between drought, heat and air humidity responses revealed by transcriptome-metabolome co-analysis Open
Correlations of targeted metabolites from GC-MS dataset used for evaluation. Pearson correlations between GC-MS-measured metabolites and variables of the main study datasets are given. The first sheet contains correlations of the sucrose i…
View article: Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions
Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions Open
Cancer was hypothesized to be driven by cancer stem cells (CSCs), but the metabolic determinants of CSC-like phenotype still remain elusive. Here, we present that hexosamine biosynthetic pathway (HBP) at least in part rescues cancer cell f…