Basem Mansour
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View article: Reviving Furosemide as a Metallo-β-Lactamase Inhibitor against MDR <i>Acinetobacter baumannii</i>
Reviving Furosemide as a Metallo-β-Lactamase Inhibitor against MDR <i>Acinetobacter baumannii</i> Open
Carbapenems are considered the last line of antibiotic defense against multidrug-resistant (MDR) Acinetobacter baumannii, a bacterium that can secrete carbapenemases such as metallo-β-lactamases (MBLs) to degrade carbapenems. It is …
View article: Chemical profile, virtual screening, and virulence-inhibiting properties of Sphagneticola trilobata L. essential oils against Pseudomonas aeruginosa
Chemical profile, virtual screening, and virulence-inhibiting properties of Sphagneticola trilobata L. essential oils against Pseudomonas aeruginosa Open
The escalating threat of microbial resistance underscores the urgent need for innovative solutions, including natural agents capable of attenuating virulence. This study explores the antimicrobial and anti-virulence potential of essential …
View article: Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence
Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence Open
Candida albicans is a commensal fungus that naturally inhabits the vagina. However, overgrowth of C. albicans can result in vulvovaginal candidiasis (VVC), one of the most prevalent fungal infections affecting women. The rapid emergence of…
View article: Cilostazol is a promising anti-pseudomonal virulence drug by disruption of quorum sensing
Cilostazol is a promising anti-pseudomonal virulence drug by disruption of quorum sensing Open
Resistance to antibiotics is a critical growing public health problem that desires urgent action to combat. To avoid the stress on bacterial growth that evokes the resistance development, anti-virulence agents can be an attractive strategy…
View article: Unlocking the therapeutic potential of Nigella sativa extract: phytochemical analysis and revealing antimicrobial and antioxidant marvels
Unlocking the therapeutic potential of Nigella sativa extract: phytochemical analysis and revealing antimicrobial and antioxidant marvels Open
The growing global threat of antimicrobial resistance endangers both human and animal life, necessitating the urgent discovery of novel antimicrobial solutions. Medicinal plants hold promise as sources of potential antimicrobial compounds.…
View article: Novel Quinoline-3,4-dihydropyrimidinone Hybrids Privileged Scaffolds: Design, Synthesis, and Cytotoxic Evaluation
Novel Quinoline-3,4-dihydropyrimidinone Hybrids Privileged Scaffolds: Design, Synthesis, and Cytotoxic Evaluation Open
Biologically active quinoline-3,4-dihydropyrimidin-2(1H)-one hybrids as novel monastrol analogs, were designed via molecular hybridization and structural modification rational. The synthesis was easily accessible via classical Biginelli re…
View article: Redirecting pantoprazole as a metallo-beta-lactamase inhibitor in carbapenem-resistant Klebsiella pneumoniae
Redirecting pantoprazole as a metallo-beta-lactamase inhibitor in carbapenem-resistant Klebsiella pneumoniae Open
The development of resistance to carbapenems in Klebsiella pneumoniae due to the production of metallo-β-lactamases (MBLs) is a critical public health problem because carbapenems are the last-resort drugs used for treating severe infection…
View article: Phenotypic, molecular, and in silico characterization of coumarin as carbapenemase inhibitor to fight carbapenem-resistant Klebsiella pneumoniae
Phenotypic, molecular, and in silico characterization of coumarin as carbapenemase inhibitor to fight carbapenem-resistant Klebsiella pneumoniae Open
View article: Insights on the therapeutic effect of quinolone-based compound, PPQ-8 plus Nitazoxanide, in chronic toxoplasmosis murine model
Insights on the therapeutic effect of quinolone-based compound, PPQ-8 plus Nitazoxanide, in chronic toxoplasmosis murine model Open
Background: Recent studies showed promising results of the quinolone-based compound (PPQ-8) against schistosomiasis and toxoplasmosis. It is hypothesized that combined treatment by PPQ-8 and anti-Toxoplasma drug may induce a convenient the…
View article: The anti-staphylococcal fusidic acid as an efflux pump inhibitor combined with fluconazole against vaginal candidiasis in mouse model
The anti-staphylococcal fusidic acid as an efflux pump inhibitor combined with fluconazole against vaginal candidiasis in mouse model Open
Background Candida albicans is the most common fungus that causes vaginal candidiasis in immunocompetent women and catastrophic infections in immunocompromised patients. The treatment of such infections is hindered due to the increasing em…
View article: Review of: "In-Vitro Antibacterial Activity of some Ganoderma Species: A Review"
Review of: "In-Vitro Antibacterial Activity of some Ganoderma Species: A Review" Open
View article: New Pyrazole-Clubbed Pyrimidine or Pyrazoline Hybrids as Anti-Methicillin-Resistant <i>Staphylococcus aureus</i> Agents: Design, Synthesis, <i>In Vitro</i> and <i>In Vivo</i> Evaluation, and Molecular Modeling Simulation
New Pyrazole-Clubbed Pyrimidine or Pyrazoline Hybrids as Anti-Methicillin-Resistant <i>Staphylococcus aureus</i> Agents: Design, Synthesis, <i>In Vitro</i> and <i>In Vivo</i> Evaluation, and Molecular Modeling Simulation Open
Two hybrid series of pyrazole-clubbed pyrimidines 5a-c and pyrazole-clubbed pyrazoline compounds 6a,b and 7 were designed as attractive scaffolds to be investigated in vitro and in vivo for antibac…
View article: Review of: "[Review] The antibacterial activity of Allium sativum, Thymus vulgaris, Origanum vulgare, Curcuma longa, Rosmarinus officinalis, and Cinnamomum species against various antibiotic-resistant strains of bacteria: A Literature Review"
Review of: "[Review] The antibacterial activity of Allium sativum, Thymus vulgaris, Origanum vulgare, Curcuma longa, Rosmarinus officinalis, and Cinnamomum species against various antibiotic-resistant strains of bacteria: A Literature Review" Open
Potential competing interests: No potential competing interests to declare. in introduction part :moment in history has influenced the management of infectious diseases, saving countless lives….it is better to be "moment in history had inf…
View article: Cyanopyridinone- and Cyanopyridine-Based Cancer Cell Pim-1 Inhibitors: Design, Synthesis, Radiolabeling, Biodistribution, and Molecular Modeling Simulation
Cyanopyridinone- and Cyanopyridine-Based Cancer Cell Pim-1 Inhibitors: Design, Synthesis, Radiolabeling, Biodistribution, and Molecular Modeling Simulation Open
In this study, two new series of 3-cyanopyridinones (3a-e) and 3-cyanopyridines (4a-e) were synthesized and evaluated for their cytotoxicity and Pim-1 kinase inhibitory activity adopting 3-[4,5-dimethylthiazol-2-yl]-2,5 diphe…
View article: Review of: "[Hypothesis] The protective role of Testosterone in COVID-19"
Review of: "[Hypothesis] The protective role of Testosterone in COVID-19" Open
Potential competing interests: No potential competing interests to declare.The authors hypothesis while looks correct from biological point of view regarding potential effects of Testosterone on Cytokine storm, however this hypothesis fail…
View article: In vivo Anticonvulsant and Neurotoxicity Evaluation and Docking Study of Promising Novel [1,5]-Benzodiazepine Derivatives
In vivo Anticonvulsant and Neurotoxicity Evaluation and Docking Study of Promising Novel [1,5]-Benzodiazepine Derivatives Open
Background: Benzodiazepines (BDZs) are predominantly prescribed as sedatives, anxiolytics, and anticonvulsants throughout the world and they act on the GABAA receptor.Objective: New 1,4-BDZ analogues have been designed and synthesized to b…
View article: In vitro activity of celastrol in combination with thymol against carbapenem-resistant Klebsiella pneumoniae isolates
In vitro activity of celastrol in combination with thymol against carbapenem-resistant Klebsiella pneumoniae isolates Open
View article: Synthesis and Molecular Docking Study of New Thiazole Derivatives as Potential Tubulin Polymerization Inhibitors
Synthesis and Molecular Docking Study of New Thiazole Derivatives as Potential Tubulin Polymerization Inhibitors Open
A new series of 2,4-disubstituted thiazole derivatives containing 4-(3,4,5-trimethoxyphenyl) moiety was synthesized and evaluated for their potential anticancer activity as tubulin polymerization inhibitors. All designed compounds were scr…
View article: Antibiofilm and staphyloxanthin inhibitory potential of terbinafine against Staphylococcus aureus: in vitro and in vivo studies
Antibiofilm and staphyloxanthin inhibitory potential of terbinafine against Staphylococcus aureus: in vitro and in vivo studies Open
View article: Repurposing pantoprazole and haloperidol as efflux pump inhibitors in azole resistant clinical Candida albicans and non-albicans isolates
Repurposing pantoprazole and haloperidol as efflux pump inhibitors in azole resistant clinical Candida albicans and non-albicans isolates Open
Candida species have a major role in nosocomial infections leading to high morbidity and mortality. Increased resistance to various antifungals, especially azoles is a significant problem. One of the main mechanisms for azole resist…
View article: Soil-Associated Bacillus Species: A Reservoir of Bioactive Compounds with Potential Therapeutic Activity against Human Pathogens
Soil-Associated Bacillus Species: A Reservoir of Bioactive Compounds with Potential Therapeutic Activity against Human Pathogens Open
Soil hosts myriads of living organisms with the extensive potential to produce bioactive compounds. Bacteria are the major soil inhabitants that represent a rich reservoir for antibiotic production along with their role in recycling nutrie…
View article: The Link between Occurrence of Class I Integron and Acquired Aminoglycoside Resistance in Clinical MRSA Isolates
The Link between Occurrence of Class I Integron and Acquired Aminoglycoside Resistance in Clinical MRSA Isolates Open
Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial infections because of its high resistance. Here, we study the antibiotic resistance in MRSA clinical isolates and their relation to integron I occurrence. A …
View article: Blocking angiotensin pathway induces anti-fibrotic effects in a mouse model of schistosomiasis by decreasing egg burden and granulomatous reaction
Blocking angiotensin pathway induces anti-fibrotic effects in a mouse model of schistosomiasis by decreasing egg burden and granulomatous reaction Open
infection is associated with hepatic fibrosis and portal hypertension. Previous studies reported that blocking some components of rennin angiotensin system can ameliorate the liver pathology induced by
View article: Back to Nature: Combating Candida albicans Biofilm, Phospholipase and Hemolysin Using Plant Essential Oils
Back to Nature: Combating Candida albicans Biofilm, Phospholipase and Hemolysin Using Plant Essential Oils Open
Candida albicans is the causative agent of fatal systemic candidiasis. Due to limitations of antifungals, new drugs are needed. The anti-virulence effect of plant essential oils (EOs) was evaluated against clinical C. albicans isolates inc…
View article: In vitro efficacy of new synthetic benzimidazole-related compounds against Schistosoma mansoni adult worms
In vitro efficacy of new synthetic benzimidazole-related compounds against Schistosoma mansoni adult worms Open
Objective: To evaluate the in vitro antischistosomal activity of two new synthetic benzimidazole-related compounds: NBTP-OH and NBTP-F. Methods: Schistosoma adult worms were recovered from mice infected with Schistosoma mansoni cercaria, w…
View article: 2-Chloroquinoline-3-carbaldehydes: synthesis and reactions (2012-2017)
2-Chloroquinoline-3-carbaldehydes: synthesis and reactions (2012-2017) Open
This review discuss in details the synthesis and reactions of 2-chloroquinoline-3-carbaldehydes during years of 2012-2017.The reactions are subdivided into groups, according to type of reaction, including reactions of both chloro and/or al…
View article: In vitro screening of BTP-Iso on Schistosoma mansoni and its intermediate host Biomphalaria alexandrina
In vitro screening of BTP-Iso on Schistosoma mansoni and its intermediate host Biomphalaria alexandrina Open
To test the effect of benzimidazole-derived compound (compound BTP-Iso) on cultured adult Schistosoma mansoni and clean Biomphalaria alexandrina snails. Adult schistosomes were incubated at different concentrations of compound BTP-Iso to c…