Bashar Saad
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View article: INSECTICIDAL EFFICACY OF <i>Balanite aegyptiaca</i> (L.) SEED OIL IN THE MANAGEMENT OF <i>Callosobruchus maculatus</i> (F.) (COLEOPTERA: BRUCHIDAE) ON FRESHLY INFESTED COWPEA GRAINS
INSECTICIDAL EFFICACY OF <i>Balanite aegyptiaca</i> (L.) SEED OIL IN THE MANAGEMENT OF <i>Callosobruchus maculatus</i> (F.) (COLEOPTERA: BRUCHIDAE) ON FRESHLY INFESTED COWPEA GRAINS Open
Protection of grains against infestation and damage by diverse storage insect pests is an age-long practice that ensures agricultural produce and guarantees food security. This paper reports the insecticidal efficacy of Balanite aegyptiaca…
View article: Olive Oil Polyphenols in Cancer: Molecular Mechanisms and Therapeutic Promise
Olive Oil Polyphenols in Cancer: Molecular Mechanisms and Therapeutic Promise Open
Olive oil, a cornerstone of the Mediterranean diet, is increasingly recognized not only for its cardiovascular benefits but also for its potential role in cancer prevention and therapy. Among its bioactive constituents, several phenolic co…
View article: Antibacterial Activity, Antioxidant Benefits, Chemical Composition, and Physicochemical Properties of Ziziphus jujuba Honey from Five Distinct Regions in Morocco
Antibacterial Activity, Antioxidant Benefits, Chemical Composition, and Physicochemical Properties of Ziziphus jujuba Honey from Five Distinct Regions in Morocco Open
This study provides a comprehensive evaluation of Ziziphus jujuba honey, commonly referred to as sidr honey (SH), collected from five distinct botanical origins in Morocco: SHE from Errachidia (Daraa-Tafilalet), SHZ from Zaggota (Rabat-Sal…
View article: Immunomodulatory and Anti-Inflammatory Properties of Honey and Bee Products
Immunomodulatory and Anti-Inflammatory Properties of Honey and Bee Products Open
Honey and other bee products, including propolis, royal jelly, and bee pollen, are widely recognized for their medicinal properties. Among their numerous biological activities, their anti-inflammatory and immunomodulatory effects have gain…
View article: In vitro evaluation of Hyphaene thebaica honey as a multitarget therapeutic product
In vitro evaluation of Hyphaene thebaica honey as a multitarget therapeutic product Open
Hyphaene thebaica honey, commonly known as doum honey (DH), is widely utilized in the Mediterranean region due to its putative health benefits. However, the precise mechanisms underpinning these benefits remain obscure. This study sought t…
View article: Physicochemical Properties, Chemical Composition, Antioxidant Properties, and Antibacterial Effects of Four Palestinian Honey Varieties
Physicochemical Properties, Chemical Composition, Antioxidant Properties, and Antibacterial Effects of Four Palestinian Honey Varieties Open
The present study evaluates the physicochemical attributes, antibacterial efficacy, and antioxidant capacities of four distinct varieties of honey from the West Bank region of Palestine: Assal Barsem (Medicago sativa) AB, Assal Morar (Cent…
View article: 8257 Pancreatic Neuroendocrine Tumor Presenting as Carcinoid Syndrome
8257 Pancreatic Neuroendocrine Tumor Presenting as Carcinoid Syndrome Open
Disclosure: D. Phung: None. Introduction Pancreatic neuroendocrine tumors (NETs) are rare tumors that arise in neuroendocrine cells of the pancreas. These tumors secrete a wide array of hormones. Carcinoid syndrome is a result of well-diff…
View article: 8257 Pancreatic Neuroendocrine Tumor Presenting As Carcinoid Syndrome
8257 Pancreatic Neuroendocrine Tumor Presenting As Carcinoid Syndrome Open
Disclosure: D. Phung: None. Introduction Pancreatic neuroendocrine tumors (NETs) are rare tumors that arise in neuroendocrine cells of the pancreas. These tumors secrete a wide array of hormones. Carcinoid syndrome is a result of well-diff…
View article: Occult Pancreatic Neuroendocrine Tumor Presenting as Carcinoid Syndrome
Occult Pancreatic Neuroendocrine Tumor Presenting as Carcinoid Syndrome Open
We present a case of a 50-year-old male who initially presented to the clinic with complaints of palpitations, shortness of breath, dizziness, night sweats, headaches with associated intermittent episodes of diarrhea, episodes of flushing,…
View article: Polyphenol Contents, Antibacterial and Antioxidant Effects of Four Palestinian Honey Samples, and their Anticancer Effects on Human Breast Cancer Cells
Polyphenol Contents, Antibacterial and Antioxidant Effects of Four Palestinian Honey Samples, and their Anticancer Effects on Human Breast Cancer Cells Open
The phenolic compounds of four Palestinian honey samples (PH1-PH4) and their antibacterial effects as well as their cytotoxic, cytostatic, and antimigration effects in human breast cancer cell line (MDA) were evaluated here. HPLC analysis …
View article: How Thymoquinone from Nigella sativa Accelerates Wound Healing through Multiple Mechanisms and Targets
How Thymoquinone from Nigella sativa Accelerates Wound Healing through Multiple Mechanisms and Targets Open
Wound healing is a multifaceted process necessitating the collaboration of numerous elements to mend damaged tissue. Plant and animal-derived natural compounds have been utilized for wound treatment over the centuries, with many scientific…
View article: A Review of the Anti-Obesity Effects of Wild Edible Plants in the Mediterranean Diet and Their Active Compounds: From Traditional Uses to Action Mechanisms and Therapeutic Targets
A Review of the Anti-Obesity Effects of Wild Edible Plants in the Mediterranean Diet and Their Active Compounds: From Traditional Uses to Action Mechanisms and Therapeutic Targets Open
Obesity is a long-term condition resulting from a continuous imbalance between the amount of energy consumed and expended. It is associated with premature mortality and contributes to a large portion of the global chronic disease burden, i…
View article: Management of Obesity-Related Inflammatory and Cardiovascular Diseases by Medicinal Plants: From Traditional Uses to Therapeutic Targets
Management of Obesity-Related Inflammatory and Cardiovascular Diseases by Medicinal Plants: From Traditional Uses to Therapeutic Targets Open
Inflammation is a crucial factor in the development and progression of cardiovascular diseases (CVD). Cardiac remodeling in the presence of persistent inflammation leads to myocardial fibrosis and extracellular matrix changes, which reduce…
View article: Anti-Inflammatory and Anti-Adipogenesis Effects of Alchemilla vulgaris L., Salvia officinalis L., and Vitis vinifera L. in THP-1-Derived Macrophages and 3T3-L1 Cell Line
Anti-Inflammatory and Anti-Adipogenesis Effects of Alchemilla vulgaris L., Salvia officinalis L., and Vitis vinifera L. in THP-1-Derived Macrophages and 3T3-L1 Cell Line Open
The production of pro-inflammatory and anti-inflammatory cytokines, as well as adipocyte differentiation and fat accumulation in the 3T3-L1 mouse embryo fibroblast cell line and the human monocytic cell line THP-1 were measured to determin…
View article: Prevention and Treatment of Obesity-Related Inflammatory Diseases by Edible and Medicinal Plants and Their Active Compounds
Prevention and Treatment of Obesity-Related Inflammatory Diseases by Edible and Medicinal Plants and Their Active Compounds Open
Obesity, defined by excessive fat mass and its associated low-grade chronic inflammation, leads to insulin resistance, diabetes, and metabolic dysfunctions. The immunomodulatory properties of natural agents have gained much interest in rec…
View article: Rosmarinus Officinalis L, Eriobotrya Japonica and Olea Europaea L Attenuate Adipogenesis in 3T3-L1-Derived Adipocytes and Inflammatory Response in LPS-Induced THP-1-Derived Macrophages
Rosmarinus Officinalis L, Eriobotrya Japonica and Olea Europaea L Attenuate Adipogenesis in 3T3-L1-Derived Adipocytes and Inflammatory Response in LPS-Induced THP-1-Derived Macrophages Open
This study aims to in vitro evaluate the impact of three traditionally used anti-obesity medicinal plant extracts on inflammatory mediators in the THP-1 cell line and adipocyte differentiation and fat accumulation in the 3T3-L1 cell line. …
View article: Modulatory Effects of Leave and Fruit Extracts of Ficus sycomorus on Cytostatic and Inflammatory Mediators in Monocultures and Co-cultures of Human Keratinocyte (HaCat) and Human Monocyte (THP-1) Cell Lines
Modulatory Effects of Leave and Fruit Extracts of Ficus sycomorus on Cytostatic and Inflammatory Mediators in Monocultures and Co-cultures of Human Keratinocyte (HaCat) and Human Monocyte (THP-1) Cell Lines Open
Background: Ficus sycomorus is one of the recommended antipsoriatic medicinal plants in the traditional Greco-Arab herbal medicine. However, the knowledge on its action mechanisms is limited.
Aims: Cytotoxic, cytostatic, and anti-inflamma…
View article: Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms
Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms Open
Over the last four decades, the escalation in diabetes and obesity rates has become epidemic all over the world. Diabesity describes the strong link between T2D and obesity. It correlates deeper with the elevated risks of developing cardio…
View article: Anti-Inflammatory, Antimicrobial, and Vasoconstriction Activities of an Anti-Hemorrhoidal Mixture of Alchemilla vulgaris, Conyza bonariensis, and Nigella sativa: In Vitro and Clinical Evaluations
Anti-Inflammatory, Antimicrobial, and Vasoconstriction Activities of an Anti-Hemorrhoidal Mixture of Alchemilla vulgaris, Conyza bonariensis, and Nigella sativa: In Vitro and Clinical Evaluations Open
Nigella sativa, Conyza bonariensis, and Alchemilla vulgaris are highly recommended in Greco-Arab traditional medicine as anti-hemorrhoid medicinal plants. The efficacy and safety of a topical cream (HPC) consisting of water–ethanol extract…
View article: Metabolic and Epigenetics Action Mechanisms of Antiobesity Medicinal Plants and Phytochemicals
Metabolic and Epigenetics Action Mechanisms of Antiobesity Medicinal Plants and Phytochemicals Open
Ever-growing research efforts are demonstrating the potential of medicinal plants and their phytochemicals to prevent and manage obesity, either individually or synergistically. Multiple combinations of phytochemicals can result in a syner…
View article: <i>In Vitro</i> and Randomized, Double‐Blind, Placebo‐Controlled Trial to Determine the Efficacy and Safety of Nine Antiacne Medicinal Plants
<i>In Vitro</i> and Randomized, Double‐Blind, Placebo‐Controlled Trial to Determine the Efficacy and Safety of Nine Antiacne Medicinal Plants Open
The present in vitro and randomized, double‐blind, placebo‐controlled trial aims to determine the efficacy and safety of nine Mediterranean antiacne medicinal plants. The antimicrobial, antisebum, and anti‐inflammatory activities of the pl…
View article: <i>In Vitro</i>Evaluation of the Potential Use of Propolis as a Multitarget Therapeutic Product: Physicochemical Properties, Chemical Composition, and Immunomodulatory, Antibacterial, and Anticancer Properties
<i>In Vitro</i>Evaluation of the Potential Use of Propolis as a Multitarget Therapeutic Product: Physicochemical Properties, Chemical Composition, and Immunomodulatory, Antibacterial, and Anticancer Properties Open
Propolis is a resin that honeybees produce by mixing saliva and beeswax with exudate gathered from botanical sources. The present in vitro study investigated the potential use of propolis as a multitarget therapeutic product and the physic…
View article: In Vitro Evaluation of Chemically Analyzed Hypericum Triquetrifolium Extract Efficacy in Apoptosis Induction and Cell Cycle Arrest of the HCT-116 Colon Cancer Cell Line
In Vitro Evaluation of Chemically Analyzed Hypericum Triquetrifolium Extract Efficacy in Apoptosis Induction and Cell Cycle Arrest of the HCT-116 Colon Cancer Cell Line Open
Naturally derived drugs and plant-based products are attractive commodities that are being explored for cancer treatment. This in vitro study aimed to investigate the role of Hypericum triquetrifolium (50% ethanol: 50% water) extract (HTE)…
View article: Chemical Analysis and Cytotoxic and Cytostatic Effects of Twelve Honey Samples Collected from Different Regions in Morocco and Palestine
Chemical Analysis and Cytotoxic and Cytostatic Effects of Twelve Honey Samples Collected from Different Regions in Morocco and Palestine Open
The aim of this in vitro study is to characterize the phenolic compounds of twelve honey samples collected from different locations in Palestine (H1-6) and Morocco (H7-12) and to evaluate their cytotoxic and cytostatic effects in cells fro…
View article: Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants
Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants Open
Diabetes is a predominant metabolic disease nowadays due to the off-beam lifestyle of diet and reduced physical activity. Complications of the illness include the gene-environment interactions and the downstream genetic and epigenetic cons…
View article: In vitro evaluations of cytotoxicity of Abelmoschus esculentus L., Asparagus aphyllus L. and Crataegus azarolus L. extracts and their effects on GLUT4 membrane translocation on L6 muscle cells and blood glucose levels in mice
In vitro evaluations of cytotoxicity of Abelmoschus esculentus L., Asparagus aphyllus L. and Crataegus azarolus L. extracts and their effects on GLUT4 membrane translocation on L6 muscle cells and blood glucose levels in mice Open
Despite the enormous achievements in the development of conventional drugs, herbal-based medicines are still a common practice for the prevention/treatment of diabetes and its related complications.Asparagus aphyllus L. (AA), Abelmoschus e…
View article: Teucrium polium extracts stimulate GLUT4 translocation to the plasma membrane in L6 muscle cells
Teucrium polium extracts stimulate GLUT4 translocation to the plasma membrane in L6 muscle cells Open
Teucrium polium L. (TP) is recommended by herbal and integrative practitioners for the treatment of diabetes.However, its mechanism of action in stimulating GLUT4 activity and translocation to the plasma membrane is still unknown.This in v…
View article: <i>Gundelia tournefortii</i> Antidiabetic Efficacy: Chemical Composition and GLUT4 Translocation
<i>Gundelia tournefortii</i> Antidiabetic Efficacy: Chemical Composition and GLUT4 Translocation Open
In the present in vitro study, we tested the chemical composition, cytotoxicity and antidiabetic activity of two distinct extracts of wild Artichoke‐like vegetable, Gundelia tournefortii : methanol and hexane. GC/MS phytochemical analysis …