Bashdar Mahmud Hussen
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View article: The dual role of cyclin D1: Unraveling its tumor-promoting mechanisms and opportunities for therapeutics
The dual role of cyclin D1: Unraveling its tumor-promoting mechanisms and opportunities for therapeutics Open
Cyclin D1, a crucial cell cycle regulator, is well-known to be a strong oncogene that is often dysregulated or overexpressed in a variety of human malignancies. It is a key therapeutic target because of its typical role in promoting G1/S p…
View article: MAPK14 and its associated lncRNAs are up-regulated in lung tumors
MAPK14 and its associated lncRNAs are up-regulated in lung tumors Open
View article: Integrating AI and RNA biomarkers in cancer: advances in diagnostics and targeted therapies
Integrating AI and RNA biomarkers in cancer: advances in diagnostics and targeted therapies Open
Early detection and personalized treatment strategies are essential for enhancing patient outcomes, as cancer continues to be a significant cause of mortality on a global basis. In clinical practice, the identification and validation of re…
View article: CRISPR/Cas as a tool to overcome drug resistance in cancer: From challenge to opportunity
CRISPR/Cas as a tool to overcome drug resistance in cancer: From challenge to opportunity Open
Drug resistance remains a significant challenge in cancer therapy, often resulting in treatment failure, tumor progression, and metastasis. The underlying resistance mechanisms-including genetic mutations, epigenetic alterations, and modif…
View article: Differential expression of lncRNAs in lung cancer subgroups
Differential expression of lncRNAs in lung cancer subgroups Open
View article: Significant upregulation of prenyltransferase-related genes in neuromyelitis optica: Diagnostic potential and clinical correlations
Significant upregulation of prenyltransferase-related genes in neuromyelitis optica: Diagnostic potential and clinical correlations Open
Protein prenylation is an important posttranslational modification being involved in several processes such as regulation of immune response. Here, we analyzed expression of four genes from this pathway, namely FNTA, RABGGTA, RABGGTB and P…
View article: Circular RNAs as a therapeutic modality for viral infections and innovative strategies to overcome key challenges: A review
Circular RNAs as a therapeutic modality for viral infections and innovative strategies to overcome key challenges: A review Open
Circular RNAs (circRNAs) are small noncoding RNAs with covalently closed loop structures, offering high stability and resistance to exonuclease degradation-traits that make them promising for diagnostic and therapeutic use. CircRNAs partic…
View article: Correction to: Alteration in the expression of long non‑coding RNAs in the circulation of migraineurs
Correction to: Alteration in the expression of long non‑coding RNAs in the circulation of migraineurs Open
View article: Up-regulation of MAPK14-related lncRNAs in the circulation of migraineurs
Up-regulation of MAPK14-related lncRNAs in the circulation of migraineurs Open
View article: Tissue levels of regulatory T cell related lncRNAs in lung cancer: evidence for dysregulation of immune responses
Tissue levels of regulatory T cell related lncRNAs in lung cancer: evidence for dysregulation of immune responses Open
In brief, we demonstrated dysregulation of three Treg-related lncRNAs in lung cancer tissues and suggested them as possible candidates for biomarker discovery investigations.
View article: MiRNA-155: A double-edged sword in colorectal cancer progression and drug resistance mechanisms
MiRNA-155: A double-edged sword in colorectal cancer progression and drug resistance mechanisms Open
Colorectal cancer (CRC) is a leading cause of death worldwide due to its aggressive nature and drug resistance, which limit traditional treatment effectiveness. Recent studies highlight the role of microRNAs (miRNAs) in tumorigenesis, meta…
View article: Circular RNAs as key regulators in cancer hallmarks: New progress and therapeutic opportunities
Circular RNAs as key regulators in cancer hallmarks: New progress and therapeutic opportunities Open
Circular RNAs (circRNAs) have emerged as critical regulators in cancer biology, contributing to various cancer hallmarks, including cell proliferation, apoptosis, metastasis, and drug resistance. Defined by their covalently closed loop str…
View article: Molecular Mechanisms of Breast Cancer Drug Resistance and CRISPR/Cas9 Strategies to Overcome
Molecular Mechanisms of Breast Cancer Drug Resistance and CRISPR/Cas9 Strategies to Overcome Open
Breast cancer (BC) is considered as the most frequent cancer among women and a significant contributor to mortality. The CRISPR/Cas9 gene-editing tool has promising applications for BC drug resistance. It is a unique and creative approach …
View article: Corrigendum: The impact of non-coding RNAs in the epithelial to mesenchymal transition
Corrigendum: The impact of non-coding RNAs in the epithelial to mesenchymal transition Open
[This corrects the article DOI: 10.3389/fmolb.2021.665199.].
View article: New insights of LncRNAs fingerprints in breast cancer progression: Tumorigenesis, drug resistance, and therapeutic opportunities
New insights of LncRNAs fingerprints in breast cancer progression: Tumorigenesis, drug resistance, and therapeutic opportunities Open
Breast cancer (BC) is one of the common female cancers and it is characterized by considerable problems regarding its development and therapy. Long non-coding RNAs (lncRNAs) have been identified as significant modulators in BC development,…
View article: Revolutionizing medicine: recent developments and future prospects in stem-cell therapy
Revolutionizing medicine: recent developments and future prospects in stem-cell therapy Open
Stem-cell therapy is a revolutionary frontier in modern medicine, offering enormous capacity to transform the treatment landscape of numerous debilitating illnesses and injuries. This review examines the revolutionary frontier of treatment…
View article: Role of microRNAs in neutrophil extracellular trap formation and prevention: Systematic narrative review
Role of microRNAs in neutrophil extracellular trap formation and prevention: Systematic narrative review Open
Active neutrophils play a variety of roles in both innate and adaptive immune responses, and one of the most vital roles is the formation and release of neutrophil extracellular traps (NETs). NETs are created when neutrophils release their…
View article: CRISPR/Cas9 gene editing: a novel strategy for fighting drug resistance in respiratory disorders
CRISPR/Cas9 gene editing: a novel strategy for fighting drug resistance in respiratory disorders Open
View article: Advanced strategies of targeting circular RNAs as therapeutic approaches in colorectal cancer drug resistance
Advanced strategies of targeting circular RNAs as therapeutic approaches in colorectal cancer drug resistance Open
Colorectal cancer (CRC) stands second in terms of mortality and third among the highest prevalent kinds of cancer globally. CRC prevalence is rising in moderately and poorly developed regions and is greater in economically advanced regions…
View article: Advanced approaches of the use of circRNAs as a replacement for cancer therapy
Advanced approaches of the use of circRNAs as a replacement for cancer therapy Open
View article: Mesenchymal stromal cells (MSCs) as a therapeutic agent of inflammatory disease and infectious COVID-19 virus: live or dead mesenchymal?
Mesenchymal stromal cells (MSCs) as a therapeutic agent of inflammatory disease and infectious COVID-19 virus: live or dead mesenchymal? Open
View article: A review on the role of FOXD2-AS1 in human disorders
A review on the role of FOXD2-AS1 in human disorders Open
FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) is a long non-coding RNA being transcribed from a locus on chromosome 1p33. This transcript has been found to be up-regulated in tumor samples of almost all types of malignancies in associat…
View article: Role of circular RNAs and gut microbiome in gastrointestinal cancers and therapeutic targets
Role of circular RNAs and gut microbiome in gastrointestinal cancers and therapeutic targets Open
Gastrointestinal cancers are a huge worldwide health concern, which includes a wide variety of digestive tract cancers. Circular RNAs (circRNAs), a kind of non-coding RNA (ncRNAs), are a family of single-stranded, covalently closed RNAs th…
View article: Antioxidant therapy against <scp>TGF</scp>‐β/<scp>SMAD</scp> pathway involved in organ fibrosis
Antioxidant therapy against <span>TGF</span>‐β/<span>SMAD</span> pathway involved in organ fibrosis Open
Fibrosis refers to excessive build‐up of scar tissue and extracellular matrix components in different organs. In recent years, it has been revealed that different cytokines and chemokines, especially Transforming growth factor beta (TGF‐β)…
View article: Abnormal level of VDR-associated lncRNAs in patients with multiple sclerosis
Abnormal level of VDR-associated lncRNAs in patients with multiple sclerosis Open
Long non-coding RNAs (lncRNAs) influence pathoetiology of multiple sclerosis (MS). We identified expression levels of three vitamin D receptor-associated lncRNAs, namely SNHG6, SNHG16 and LINC00346 in the blood of MS patients compared with…
View article: Diversity of biofilm-specific antimicrobial resistance genes in Pseudomonas aeruginosa recovered from various clinical isolates
Diversity of biofilm-specific antimicrobial resistance genes in Pseudomonas aeruginosa recovered from various clinical isolates Open
Background and Objectives: The resistance of Pseudomonas aeruginosa to antibiotics offers a significant challenge in the treatment of patients. This study aimed to investigate the antimicrobial resistance profile, biofilm-specific antimicr…
View article: Association between HOTAIR genetic variants and risk of obsessive-compulsive disorder
Association between HOTAIR genetic variants and risk of obsessive-compulsive disorder Open
HOX transcript antisense intergenic RNA (HOTAIR) is a long non-coding RNA with important roles in regulation of autophagy, neurite growth and morphogenesis. Polymorphisms within this gene have been associated with some neuropsychiatric con…
View article: Circular RNAs and inflammation: Epigenetic regulators with diagnostic role
Circular RNAs and inflammation: Epigenetic regulators with diagnostic role Open
Circular RNAs (circRNAs) are a group of transcripts generally known to be non-coding transcripts, but occasionally producing short peptides. Circ_Ttc3/miR-148a, circ_TLK1/miR-106a-5p, circ_VMA21/miR-9-3p, circ_0068,888/miR-21-5p, circ_VMA2…
View article: LncRNA SNHG12: A budding star in human diseases
LncRNA SNHG12: A budding star in human diseases Open
View article: New insights of miRNA molecular mechanisms in breast cancer brain metastasis and therapeutic targets
New insights of miRNA molecular mechanisms in breast cancer brain metastasis and therapeutic targets Open